Take orally with a full glass of water, preferably sitting upright or standing, to prevent esophageal irritation. Can be taken with food to reduce stomach upset, but avoid dairy products, antacids, and iron supplements within 2 hours of dose.

Inhibits bacterial protein synthesis by binding to the 30S ribosomal subunit, preventing the attachment of aminoacyl tRNA to the ribosomal A site.

• •Hypersensitivity to doxycycline or other tetracyclines
• •Pregnancy (especially second and third trimesters)
• •Children under 8 years of age (due to potential for tooth discoloration and bone growth inhibition)

Store below 30°C in a dry place, away from direct light and moisture. Keep out of reach of children.

Symptoms may include nausea, vomiting, and diarrhea. Management is supportive; gastric lavage or induced emesis may be considered soon after ingestion. Hemodialysis is not effective.

Pregnancy Category D. Contraindicated during the second and third trimesters due to potential for permanent tooth discoloration and skeletal effects in the fetus. Not recommended during lactation as it is excreted into breast milk and can cause tooth discoloration in infants.