Doxolator
Generic Name
Doxolator 100 mg Syrup
Manufacturer
PharmaLife Laboratories Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| doxolator 100 mg syrup | ৳ 100.00 | N/A |
Description
Overview of the medicine
Doxolator is an oral solution containing 100 mg of an active compound per 5 ml, primarily used for the treatment of various forms of depression and anxiety disorders. It belongs to the tricyclic antidepressant class, working by balancing certain neurotransmitters in the brain.
Uses & Indications
Dosage
Adults
Initial dose 25-50 mg orally at bedtime, gradually increasing to 100-300 mg daily in divided doses or as a single bedtime dose. Max 300 mg/day.
Elderly
Lower initial dose (e.g., 10-25 mg at bedtime) and slower titration due to increased sensitivity and potential for adverse effects. Max 150 mg/day.
Renal_impairment
No specific dose adjustment for mild to moderate impairment, but caution advised. For severe impairment, dose reduction may be necessary.
How to Take
Oral. Can be taken with or without food. To minimize sedation, larger portion of daily dose can be taken at bedtime.
Mechanism of Action
Doxolator primarily inhibits the reuptake of norepinephrine and serotonin into presynaptic neurons, thereby increasing the concentration of these neurotransmitters in the synaptic cleft. This leads to an improvement in mood and reduction in anxiety.
Pharmacokinetics
Onset
Antidepressant effects may take 2-4 weeks to manifest, while sedative effects can be immediate.
Excretion
Primarily excreted in urine as metabolites, with a small amount excreted in feces.
Half life
Variable, ranging from 10 to 25 hours for the parent compound and active metabolites.
Absorption
Rapidly absorbed after oral administration, peak plasma concentrations typically reached within 2-4 hours.
Metabolism
Extensively metabolized in the liver via cytochrome P450 enzymes, primarily CYP2D6 and CYP3A4, to active and inactive metabolites.
Side Effects
Contraindications
- Hypersensitivity to doxolator or any component
- Recent myocardial infarction
- Concomitant use with MAOIs
- Acute angle-closure glaucoma
- Severe hepatic impairment
Drug Interactions
MAOIs
Serious, potentially fatal reactions including hyperthermia, rigidity, myoclonus, autonomic instability, and mental status changes. Avoid concomitant use; a washout period is required.
Anticholinergics
Potentiated anticholinergic effects (dry mouth, blurred vision, constipation, urinary retention).
CNS Depressants (alcohol, sedatives, hypnotics)
Increased CNS depressant effects.
Cytochrome P450 Inhibitors (e.g., cimetidine, fluoxetine)
May increase plasma levels of doxolator.
Storage
Store below 30°C in a dry place, protected from light. Keep out of reach of children.
Overdose
Symptoms include severe drowsiness, confusion, agitation, hallucinations, blurred vision, dry mouth, urinary retention, dilated pupils, fever, fast or irregular heartbeat, seizures, and coma. Management involves symptomatic and supportive care, gastric lavage, activated charcoal, and monitoring vital signs. Physostigmine may be used for severe anticholinergic symptoms.
Pregnancy & Lactation
Pregnancy Category C. Use only if potential benefit outweighs risk. Excreted in breast milk, caution advised. Consult doctor.
Side Effects
Contraindications
- Hypersensitivity to doxolator or any component
- Recent myocardial infarction
- Concomitant use with MAOIs
- Acute angle-closure glaucoma
- Severe hepatic impairment
Drug Interactions
MAOIs
Serious, potentially fatal reactions including hyperthermia, rigidity, myoclonus, autonomic instability, and mental status changes. Avoid concomitant use; a washout period is required.
Anticholinergics
Potentiated anticholinergic effects (dry mouth, blurred vision, constipation, urinary retention).
CNS Depressants (alcohol, sedatives, hypnotics)
Increased CNS depressant effects.
Cytochrome P450 Inhibitors (e.g., cimetidine, fluoxetine)
May increase plasma levels of doxolator.
Storage
Store below 30°C in a dry place, protected from light. Keep out of reach of children.
Overdose
Symptoms include severe drowsiness, confusion, agitation, hallucinations, blurred vision, dry mouth, urinary retention, dilated pupils, fever, fast or irregular heartbeat, seizures, and coma. Management involves symptomatic and supportive care, gastric lavage, activated charcoal, and monitoring vital signs. Physostigmine may be used for severe anticholinergic symptoms.
Pregnancy & Lactation
Pregnancy Category C. Use only if potential benefit outweighs risk. Excreted in breast milk, caution advised. Consult doctor.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months from manufacturing date
Availability
Pharmacies nationwide
Approval Status
Approved by DGDA
Patent Status
Generic available
Clinical Trials
Extensive clinical trials have demonstrated efficacy in major depressive disorder and generalized anxiety disorder, with a well-established safety profile comparable to other TCAs. Further post-marketing surveillance ongoing.
Lab Monitoring
- Baseline and periodic ECG (due to cardiac effects)
- Liver function tests
- Complete blood count (rare bone marrow depression)
- Baseline serum electrolytes
Doctor Notes
- Counsel patients on delayed onset of antidepressant effect and potential for sedation and anticholinergic side effects.
- Monitor for suicidal ideation, especially at initiation or dose changes.
- Consider ECG before and during treatment, especially in elderly or patients with pre-existing cardiac conditions.
Patient Guidelines
- Do not stop taking this medicine abruptly, as withdrawal symptoms may occur. Gradual tapering is required.
- Avoid alcohol and other CNS depressants.
- Report any new or worsening depression, suicidal thoughts, or unusual changes in mood or behavior.
- May cause drowsiness or blurred vision; use caution when driving or operating machinery.
Missed Dose Advice
If a dose is missed, take it as soon as you remember, unless it is almost time for your next dose. Do not double the dose. Consult your doctor.
Driving Precautions
Doxolator can cause drowsiness, dizziness, and blurred vision, especially at the start of treatment. Patients should be advised not to drive or operate hazardous machinery until they know how the medication affects them.
Lifestyle Advice
- Maintain a healthy diet and regular exercise routine.
- Practice stress reduction techniques like meditation or yoga.
- Ensure adequate sleep hygiene.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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