Medicine Information

Duvent

Name: Duvent
Brand: Duvent
Rating: 4.5 (117 reviews)

Tablet10 mgAntihistamines (H1-receptor antagonists)ATC: R06AX29

Generic Name

Bilastine

Manufacturer

Healthcare Pharmaceuticals Ltd.

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
duvent 10 mg tablet	৳ 10.00	৳ 100.00

Description

Overview of the medicine

Duvent 10 mg Tablet contains Bilastine, a non-sedating second-generation antihistamine used to relieve symptoms of allergic rhinoconjunctivitis (sneezing, itchy nose, watery eyes) and urticaria (hives and skin rash). This strength is typically indicated for children aged 6 to 11 years.

Uses & Indications

Symptomatic treatment of allergic rhinoconjunctivitis (seasonal and perennial)

Symptomatic treatment of urticaria (hives)

Specifically, 10 mg strength is indicated for children aged 6 to 11 years weighing at least 20 kg.

Dosage

Adults

The standard adult dose for Bilastine is 20 mg once daily. Duvent 10 mg is typically not indicated for adults; for adult use, consult for 20 mg strength.

Elderly

No dose adjustment is required in elderly patients.

Renal_impairment

No dose adjustment is required for mild to moderate renal impairment. For severe renal impairment, consult a physician.

How to Take

Take the tablet orally with water, preferably one hour before or two hours after food. Do not take with grapefruit juice or other fruit juices.

Mechanism of Action

Bilastine acts as a selective peripheral histamine H1 receptor antagonist. It prevents histamine from binding to H1 receptors, thereby inhibiting the symptoms caused by histamine release during allergic reactions. It has no significant anticholinergic activity and does not cross the blood-brain barrier significantly, contributing to its non-sedating profile.

Pharmacokinetics

Onset

Onset of action typically occurs within 30-60 minutes.

Excretion

Approximately 95% of the dose is excreted unchanged, with about 67% eliminated via feces and 33% via urine.

Half life

Elimination half-life ranges from 8 to 12 hours.

Absorption

Rapidly absorbed after oral administration. Oral bioavailability is approximately 60%. Absorption is reduced significantly by food and grapefruit juice.

Metabolism

Not significantly metabolized by the liver. It does not induce or inhibit cytochrome P450 isoenzymes.

Side Effects

Contraindications

Hypersensitivity to Bilastine or any of the excipients.

Drug Interactions

Diltiazem

Can increase plasma concentrations of Bilastine.

P-glycoprotein inhibitors

Caution advised when co-administering with other P-glycoprotein inhibitors as they may increase Bilastine systemic exposure.

Ketoconazole and Erythromycin

Can increase plasma concentrations of Bilastine.

Storage

Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.

Overdose

In case of overdose, symptomatic and supportive treatment is recommended. There is no specific antidote for Bilastine. Gastric lavage and activated charcoal may be considered if appropriate.

Pregnancy & Lactation

Pregnancy Category B. Limited data on use in pregnant women. Should be used only if clearly necessary and the potential benefit justifies the potential risk to the fetus. Not recommended during breastfeeding as it is unknown if Bilastine is excreted in human milk.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

10 tablets per box20 tablets per box

Shelf Life

36 months

Availability

Available in pharmacies and hospitals

Approval Status

Approved by DGDA (Bangladesh)

Patent Status

Brand specific patent protection

Clinical Trials

Bilastine has undergone extensive clinical trials demonstrating its efficacy and safety in the symptomatic treatment of allergic rhinoconjunctivitis and urticaria in both adults and children (specific trials for 10mg in pediatric population).

Lab Monitoring

No specific routine laboratory monitoring is required.

Doctor Notes

Emphasize strict adherence to administration instructions: take on an empty stomach and avoid fruit juices.
Confirm patient's age and weight, as 10mg is typically for children aged 6-11 years, weight at least 20kg.
Advise patients about potential for mild drowsiness, although it is generally non-sedating.

Patient Guidelines

Take Duvent 10 mg tablet on an empty stomach (one hour before or two hours after food).
Do not take with grapefruit juice or other fruit juices.
Do not exceed the recommended dose.
If symptoms do not improve, consult your doctor.

Missed Dose Advice

If you miss a dose, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose.

Driving Precautions

Bilastine is generally non-sedating at recommended doses. However, individuals may react differently. It is advisable to ascertain your response to the medication before driving or operating machinery.