Dysnov
Generic Name
Desloratadine
Manufacturer
Incepta Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| dysnov 5 mg suspension | ৳ 40.00 | N/A |
Description
Overview of the medicine
Desloratadine is a non-drowsy antihistamine used to relieve symptoms of allergic rhinitis (including hay fever) and chronic idiopathic urticaria (hives). It helps to reduce sneezing, runny nose, itchy or watery eyes, and itching of the skin.
Uses & Indications
Dosage
Adults
5 mg (10 mL of 0.5 mg/mL suspension or 5 mL of 1 mg/mL suspension) once daily. For Dysnov 5 mg suspension, typically 5 mL (assuming 1 mg/mL concentration, or 10 mL if 0.5 mg/mL, check product specific label). Assuming 5 mg/5 mL, thus 5 mL once daily for 12+ years.
Elderly
No specific dosage adjustment is generally required, but caution is advised in patients with renal or hepatic impairment.
Renal_impairment
For adults and adolescents with renal impairment, a starting dose of 5 mg every other day is recommended.
How to Take
Oral administration. May be taken with or without food. Use an accurate measuring device (e.g., dosing syringe or measuring spoon) to administer the suspension.
Mechanism of Action
Desloratadine is a long-acting, tricyclic antihistamine with selective peripheral H1-receptor antagonist activity. It prevents histamine from binding to H1-receptors, thereby inhibiting the effects of histamine such as vasodilation, increased capillary permeability, and stimulation of sensory nerves.
Pharmacokinetics
Onset
Within 30-60 minutes.
Excretion
Excreted in urine (approx. 41%) and feces (approx. 47%) as metabolites.
Half life
Approximately 27 hours (terminal elimination half-life).
Absorption
Rapidly absorbed from the gastrointestinal tract following oral administration. Peak plasma concentrations are reached approximately 3 hours after dosing.
Metabolism
Extensively metabolized, primarily to 3-hydroxydesloratadine, a major active metabolite. It is metabolized by glucuronidation and hydroxylation.
Side Effects
Contraindications
- Hypersensitivity to desloratadine, loratadine, or any component of the formulation.
Drug Interactions
Cimetidine
Increases plasma concentration of desloratadine and 3-hydroxydesloratadine.
Fluoxetine
Increases plasma concentration of desloratadine and 3-hydroxydesloratadine.
Azithromycin
Increases plasma concentration of desloratadine and 3-hydroxydesloratadine.
Erythromycin
Increases plasma concentration of desloratadine and 3-hydroxydesloratadine.
Ketoconazole
Increases plasma concentration of desloratadine and 3-hydroxydesloratadine.
Storage
Store below 30°C. Protect from light and moisture. Keep out of the reach of children. Do not freeze.
Overdose
In the event of an overdose, symptoms may include somnolence, increased heart rate, and headache. In case of overdose, initiate symptomatic and supportive treatment immediately. Desloratadine is not eliminated by hemodialysis.
Pregnancy & Lactation
Pregnancy Category C. Use only if the potential benefit justifies the potential risk to the fetus. Desloratadine is excreted into breast milk; therefore, caution should be exercised when administered to a nursing woman.
Side Effects
Contraindications
- Hypersensitivity to desloratadine, loratadine, or any component of the formulation.
Drug Interactions
Cimetidine
Increases plasma concentration of desloratadine and 3-hydroxydesloratadine.
Fluoxetine
Increases plasma concentration of desloratadine and 3-hydroxydesloratadine.
Azithromycin
Increases plasma concentration of desloratadine and 3-hydroxydesloratadine.
Erythromycin
Increases plasma concentration of desloratadine and 3-hydroxydesloratadine.
Ketoconazole
Increases plasma concentration of desloratadine and 3-hydroxydesloratadine.
Storage
Store below 30°C. Protect from light and moisture. Keep out of the reach of children. Do not freeze.
Overdose
In the event of an overdose, symptoms may include somnolence, increased heart rate, and headache. In case of overdose, initiate symptomatic and supportive treatment immediately. Desloratadine is not eliminated by hemodialysis.
Pregnancy & Lactation
Pregnancy Category C. Use only if the potential benefit justifies the potential risk to the fetus. Desloratadine is excreted into breast milk; therefore, caution should be exercised when administered to a nursing woman.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24 to 36 months from the date of manufacture. Refer to the specific product packaging for exact shelf life.
Availability
Available in pharmacies and hospitals
Approval Status
Approved by regulatory authorities (e.g., DGDA, FDA)
Patent Status
Generic available, patent expired
Clinical Trials
Extensive clinical trials have demonstrated the efficacy and safety of desloratadine for the treatment of allergic rhinitis and chronic idiopathic urticaria across various age groups.
Lab Monitoring
- Generally, no specific laboratory monitoring is required for desloratadine. In patients with hepatic or renal impairment, liver and kidney function tests may be monitored if clinically indicated.
Doctor Notes
- Counsel patients on proper administration technique for suspension, especially for pediatric dosing.
- Advise patients that while generally non-sedating, individual responses can vary; caution should be exercised with activities requiring mental alertness.
- Monitor patients with severe renal or hepatic impairment for potential dose adjustments.
Patient Guidelines
- Follow your doctor's instructions regarding dosage and duration of treatment.
- Do not exceed the recommended dose.
- Inform your doctor about all other medications you are taking, including over-the-counter drugs and herbal supplements.
- If symptoms do not improve or worsen, consult your doctor.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Desloratadine is generally non-sedating. However, individuals should be aware of how they react to the medication before driving or operating machinery. If drowsiness occurs, avoid these activities.
Lifestyle Advice
- Identify and avoid exposure to known allergens that trigger your symptoms.
- Maintain adequate hydration.
- For allergic rhinitis, consider nasal rinsing with saline solution.
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