e-pod
Generic Name
Cefpodoxime Proxetil
Manufacturer
Incepta Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| e pod 200 mg capsule | ৳ 40.00 | N/A |
Description
Overview of the medicine
Cefpodoxime is a third-generation cephalosporin antibiotic used to treat a variety of bacterial infections.
Uses & Indications
Dosage
Adults
200 mg twice daily for 7-14 days depending on the infection.
Elderly
No specific dose adjustment typically required unless severe renal impairment.
Renal_impairment
Dose adjustment required for creatinine clearance < 30 mL/min (e.g., 200 mg every 24 hours).
How to Take
Orally, preferably with food to enhance absorption.
Mechanism of Action
Bactericidal; inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs).
Pharmacokinetics
Onset
Peak plasma concentrations reached in 2-3 hours.
Excretion
Primarily excreted unchanged in the urine.
Half life
Approximately 2-3 hours.
Absorption
Well absorbed from the gastrointestinal tract, especially when taken with food. Bioavailability is about 50%.
Metabolism
It is a prodrug; cefpodoxime proxetil is hydrolyzed in the gut wall to active cefpodoxime.
Side Effects
Contraindications
- Hypersensitivity to cefpodoxime or other cephalosporins.
Drug Interactions
Probenecid
Increases plasma levels of cefpodoxime by decreasing renal excretion.
Antacids/H2 blockers/PPIs
Decrease absorption of cefpodoxime.
Storage
Store below 30°C in a dry place, away from light and moisture.
Overdose
Symptoms may include nausea, vomiting, epigastric distress, and diarrhea. Management is symptomatic and supportive, hemodialysis may be beneficial.
Pregnancy & Lactation
Pregnancy Category B. Use only if clearly needed. Excreted in breast milk, use with caution during lactation.
Side Effects
Contraindications
- Hypersensitivity to cefpodoxime or other cephalosporins.
Drug Interactions
Probenecid
Increases plasma levels of cefpodoxime by decreasing renal excretion.
Antacids/H2 blockers/PPIs
Decrease absorption of cefpodoxime.
Storage
Store below 30°C in a dry place, away from light and moisture.
Overdose
Symptoms may include nausea, vomiting, epigastric distress, and diarrhea. Management is symptomatic and supportive, hemodialysis may be beneficial.
Pregnancy & Lactation
Pregnancy Category B. Use only if clearly needed. Excreted in breast milk, use with caution during lactation.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months
Availability
Pharmacies, hospitals, clinics
Approval Status
Approved by relevant regulatory bodies
Patent Status
Patent expired, generic versions available
Clinical Trials
Extensive clinical trials have established its efficacy and safety for approved indications.
Lab Monitoring
- Renal function in patients with pre-existing renal impairment.
- Complete blood count (CBC) during prolonged therapy.
Doctor Notes
- Assess renal function before initiating therapy in elderly patients or those with known renal impairment.
- Counsel patients on the importance of completing the full antibiotic course to prevent resistance.
Patient Guidelines
- Complete the full course of medication even if symptoms improve.
- Take with food to improve absorption and reduce stomach upset.
- Inform your doctor about any allergies or other medications you are taking.
Missed Dose Advice
Take the missed dose as soon as you remember. If it's almost time for your next dose, skip the missed dose and continue your regular dosing schedule. Do not double the dose.
Driving Precautions
May cause dizziness, so caution is advised when driving or operating machinery.
Lifestyle Advice
- Maintain good hygiene to prevent reinfection.
- Stay hydrated.
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