e-pod
Generic Name
Cefpodoxime Proxetil Suspension
Manufacturer
Popular Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| e pod 80 mg suspension | ৳ 96.00 | N/A |
Description
Overview of the medicine
E-pod 80 mg Suspension is a third-generation cephalosporin antibiotic used to treat a wide range of bacterial infections in children.
Uses & Indications
Dosage
Elderly
Dosage adjustment is generally not required in elderly patients unless there is severe renal impairment.
Children
Typical pediatric dosage is 5 mg/kg every 12 hours for 5 to 10 days, depending on the infection. Not to exceed 200 mg per dose.
Renal_impairment
Dosage adjustment is necessary in patients with severe renal impairment (creatinine clearance < 30 mL/min).
How to Take
Take orally with food to enhance absorption. Shake the bottle well before each use.
Mechanism of Action
It works by inhibiting the synthesis of the bacterial cell wall, leading to bacterial cell death.
Pharmacokinetics
Onset
Rapid onset of action, therapeutic concentrations achieved quickly.
Excretion
Primarily excreted unchanged by the kidneys (glomerular filtration and tubular secretion).
Half life
Plasma elimination half-life is approximately 2 to 3 hours.
Absorption
Cefpodoxime proxetil is rapidly absorbed from the gastrointestinal tract and hydrolyzed to active cefpodoxime. Bioavailability is approximately 50%.
Metabolism
Hydrolyzed to active cefpodoxime in the gastrointestinal tract. Minimal hepatic metabolism.
Side Effects
Contraindications
- Known hypersensitivity to cefpodoxime, other cephalosporins, or penicillins.
Drug Interactions
Probenecid
Increases plasma levels of cefpodoxime.
Nephrotoxic drugs
Concomitant administration with nephrotoxic drugs may increase the risk of renal toxicity (rare).
Antacids/H2 Blockers/PPIs
May decrease the absorption of cefpodoxime.
Storage
Store the dry powder below 30°C in a dry place. After reconstitution, store in a refrigerator (2-8°C) and discard any unused portion after 14 days.
Overdose
In case of overdose, supportive and symptomatic treatment should be given. Hemodialysis may be helpful in removing cefpodoxime from the body.
Pregnancy & Lactation
Pregnancy Category B. Use with caution during lactation as small amounts may pass into breast milk.
Side Effects
Contraindications
- Known hypersensitivity to cefpodoxime, other cephalosporins, or penicillins.
Drug Interactions
Probenecid
Increases plasma levels of cefpodoxime.
Nephrotoxic drugs
Concomitant administration with nephrotoxic drugs may increase the risk of renal toxicity (rare).
Antacids/H2 Blockers/PPIs
May decrease the absorption of cefpodoxime.
Storage
Store the dry powder below 30°C in a dry place. After reconstitution, store in a refrigerator (2-8°C) and discard any unused portion after 14 days.
Overdose
In case of overdose, supportive and symptomatic treatment should be given. Hemodialysis may be helpful in removing cefpodoxime from the body.
Pregnancy & Lactation
Pregnancy Category B. Use with caution during lactation as small amounts may pass into breast milk.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Dry powder: 24 to 36 months. Reconstituted suspension: 7 to 14 days when refrigerated.
Availability
Available in pharmacies and hospitals
Approval Status
Approved by regulatory authorities
Patent Status
Generic (Patent expired)
WHO Essential Medicine
YesClinical Trials
Cefpodoxime has been extensively studied in numerous clinical trials demonstrating its efficacy and safety for various bacterial infections.
Lab Monitoring
- Monitor renal function (creatinine, BUN) in patients with pre-existing renal impairment or during prolonged therapy.
- Liver function tests (ALT, AST) periodically.
- Complete blood count (CBC) occasionally.
Doctor Notes
- Ensure accurate diagnosis before initiating antibiotic therapy.
- Emphasize completing the full course of treatment to prevent resistance.
- Adjust dosage in patients with renal impairment.
Patient Guidelines
- Complete the entire course of medication, even if symptoms improve.
- Take the medicine with food.
- Shake the bottle well before each use.
- Use the provided measuring device for accurate dosing.
Missed Dose Advice
Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
Generally considered safe for driving, but caution is advised if dizziness or fatigue occurs.
Lifestyle Advice
- Stay well-hydrated during treatment.
- Avoid self-medication with antibiotics.
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