Medicine Information

e-proton

Name: e-proton
Brand: e-proton
Rating: 4.5 (117 reviews)

Capsule40 mgProton Pump Inhibitor (PPI)ATC: A02BC05

Generic Name

Esomeprazole 40 mg capsule

Manufacturer

XYZ Pharmaceuticals Ltd.

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
e proton 40 mg capsule	৳ 10.00	৳ 100.00

Description

Overview of the medicine

Esomeprazole is a proton pump inhibitor (PPI) that reduces the amount of acid produced in the stomach. It is used to treat conditions like heartburn, acid reflux, and stomach ulcers.

Uses & Indications

Gastroesophageal Reflux Disease (GERD) including erosive esophagitis

Healing of Gastric and Duodenal Ulcers

H. pylori eradication (in combination with antibiotics)

Zollinger-Ellison Syndrome

Prevention of NSAID-associated gastric ulcers

Dosage

Adults

Usually 20 mg or 40 mg once daily, depending on the indication. For erosive esophagitis, 40 mg once daily for 4-8 weeks. For H. pylori eradication, 40 mg once daily for 10 days with appropriate antibiotics.

Elderly

No specific dose adjustment is generally required for elderly patients.

Renal_impairment

No dose adjustment is necessary for patients with impaired renal function.

How to Take

Take the capsule whole with water, at least one hour before a meal, preferably in the morning. Do not chew or crush the capsule. If swallowing is difficult, the capsule can be opened and the pellets mixed with a small amount of water or fruit juice and swallowed immediately.

Mechanism of Action

Esomeprazole works by irreversibly binding to and inhibiting the H+/K+-ATPase enzyme (the proton pump) on the secretory surface of the gastric parietal cells. This action effectively blocks the final step in gastric acid production, leading to a sustained decrease in acid secretion.

Pharmacokinetics

Onset

Acid inhibition begins within 1 hour of oral administration.

Excretion

Approximately 80% of the dose is excreted as metabolites in the urine, and the remainder in the feces.

Half life

Plasma elimination half-life is approximately 1.5 hours.

Absorption

Rapidly absorbed after oral administration, with peak plasma concentrations occurring within 1-2 hours. Bioavailability is approximately 64% after a single 40 mg dose.

Metabolism

Extensively metabolized in the liver by the cytochrome P450 (CYP) enzyme system, primarily by CYP2C19 and CYP3A4.

Side Effects

Contraindications

Hypersensitivity to esomeprazole, substituted benzimidazoles, or any components of the formulation
Concomitant use with nelfinavir (an antiretroviral drug)

Drug Interactions

Warfarin

Potential for increased INR and bleeding risk.

Clopidogrel

Reduced antiplatelet effect of clopidogrel due to CYP2C19 inhibition.

Methotrexate

May increase serum levels of methotrexate, particularly with high doses.

Nelfinavir/Atazanavir

Decreased plasma levels of nelfinavir and atazanavir due to reduced absorption.

Storage

Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.

Overdose

Limited experience with overdose. Symptoms may include gastrointestinal disturbances and weakness. Treatment is symptomatic and supportive. Esomeprazole is not readily dialyzable.

Pregnancy & Lactation

Use during pregnancy only if clearly needed and the potential benefits outweigh the potential risks to the fetus. It is unknown if esomeprazole is excreted in human milk; use with caution during lactation.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

10 capsules per blister pack30 capsules per box

Shelf Life

24-36 months from manufacturing date

Availability

Available in pharmacies and hospitals

Approval Status

Approved by major regulatory bodies (e.g., FDA, DGDA)

Patent Status

Patent expired, generics available

WHO Essential Medicine

Yes

Clinical Trials

Esomeprazole has undergone extensive clinical trials demonstrating its efficacy and safety in various acid-related disorders, leading to its widespread approval and use globally.

Lab Monitoring

Magnesium levels (if used long-term or with other magnesium-lowering drugs)
Vitamin B12 levels (for prolonged therapy, >3 years)
Liver function tests (in patients with severe hepatic impairment)

Doctor Notes

Use the lowest effective dose for the shortest duration necessary.
Reassess the need for continued PPI therapy periodically, especially for long-term users.
Consider magnesium supplementation for patients on long-term PPI therapy, particularly if also on diuretics or other magnesium-lowering drugs.
PPIs may mask symptoms of gastric malignancy; conduct appropriate diagnostic evaluation if gastric malignancy is suspected.

Patient Guidelines

Take exactly as prescribed by your doctor.
Do not chew or crush the capsule; swallow it whole.
Take at least one hour before a meal for best results.
Inform your doctor about all other medications you are taking.
Do not stop taking the medicine suddenly without consulting your doctor.

Missed Dose Advice

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.

Driving Precautions

Esomeprazole is generally not expected to affect the ability to drive or operate machinery. However, side effects like dizziness or blurred vision have been reported rarely. If these occur, patients should avoid driving or operating machinery.

Lifestyle Advice

Avoid trigger foods and beverages (e.g., fatty foods, spicy foods, caffeine, alcohol).
Eat smaller, more frequent meals.
Avoid lying down immediately after eating.
Elevate the head of your bed to reduce nighttime reflux.
Maintain a healthy weight.