Ecox
Generic Name
Etoricoxib
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| ecox 120 mg tablet | ৳ 14.07 | ৳ 140.67 |
Description
Overview of the medicine
Ecox 120 mg tablet contains Etoricoxib, a selective cyclooxygenase-2 (COX-2) inhibitor, used for the relief of pain and inflammation in various musculoskeletal and joint conditions.
Uses & Indications
Dosage
Adults
Osteoarthritis: 30 mg or 60 mg once daily. Rheumatoid Arthritis, Ankylosing Spondylitis: 60 mg or 90 mg once daily. Acute Gouty Arthritis: 120 mg once daily (for a maximum of 8 days). Acute Pain/Primary Dysmenorrhea: 120 mg once daily (for a maximum of 8 days). Dosage should be the lowest effective dose for the shortest duration necessary.
Elderly
No specific dosage adjustment is generally required based on age alone, but caution should be exercised due to increased risk of adverse effects.
Renal_impairment
Mild to moderate renal impairment (CrCl 30-80 mL/min): No dosage adjustment. Severe renal impairment (CrCl <30 mL/min): Not recommended.
How to Take
Ecox 120 mg tablet should be taken orally, with or without food. For acute conditions, it should be used for the shortest possible duration.
Mechanism of Action
Etoricoxib selectively inhibits cyclooxygenase-2 (COX-2), an enzyme responsible for the synthesis of prostaglandins, which are mediators of pain and inflammation. By inhibiting COX-2, it reduces the production of these inflammatory mediators, thus alleviating pain and inflammation while minimizing gastrointestinal side effects associated with non-selective NSAIDs.
Pharmacokinetics
Onset
Within 24 minutes for acute pain, up to a few hours for chronic conditions.
Excretion
Mainly excreted renally (approximately 70%) and fecally (approximately 30%), primarily as metabolites.
Half life
Approximately 22 hours.
Absorption
Rapidly absorbed after oral administration, peak plasma concentrations reached in approximately 1 hour.
Metabolism
Extensively metabolized by cytochrome P450 enzymes (mainly CYP3A4) to inactive metabolites.
Side Effects
Contraindications
- •Hypersensitivity to etoricoxib or any component of the tablet
- •Active peptic ulceration or gastrointestinal bleeding
- •Patients with severe liver dysfunction
- •Patients with estimated creatinine clearance <30 mL/min
- •Congestive heart failure (NYHA Class II-IV)
- •Established ischemic heart disease, peripheral arterial disease, and/or cerebrovascular disease
- •Uncontrolled hypertension
- •Third trimester of pregnancy
Drug Interactions
Lithium
Increased plasma lithium levels, leading to toxicity. Monitor lithium levels.
Warfarin
Increased INR and bleeding risk. Monitor INR closely.
Methotrexate
Increased plasma methotrexate levels, potentially enhancing toxicity. Use with caution.
Oral Contraceptives
Increased plasma concentrations of ethinyl estradiol, potentially increasing adverse effects of oral contraceptives.
Cyclosporine/Tacrolimus
Increased nephrotoxicity. Use with caution.
ACE Inhibitors/ARBs/Diuretics
Reduced antihypertensive effect and increased risk of renal impairment. Monitor blood pressure and renal function.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose are generally consistent with the known adverse effects of NSAIDs (e.g., gastrointestinal disturbances, renal toxicity, cardiovascular events). Management is symptomatic and supportive. There is no specific antidote.
Pregnancy & Lactation
Pregnancy Category C (first two trimesters) / D (third trimester). Avoid use in the third trimester due to potential adverse effects on the fetal cardiovascular system. Avoid during lactation as etoricoxib is excreted in breast milk.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from manufacturing date, refer to package for exact expiry.
Availability
Available in pharmacies worldwide
Approval Status
Approved by regulatory authorities worldwide, including FDA and DGDA (for generic versions)
Patent Status
Generic versions available, original patent expired in many regions.
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Global Brand Names
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