Ectover
Generic Name
Ivermectin
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| ectover 12 mg tablet | ৳ 20.00 | ৳ 200.00 |
Description
Overview of the medicine
Ivermectin is an anti-parasitic medication used to treat certain parasitic infections in humans, including strongyloidiasis, onchocerciasis, scabies, and pediculosis.
Uses & Indications
Dosage
Adults
Strongyloidiasis: 200 mcg/kg as a single oral dose. Onchocerciasis: 150 mcg/kg as a single oral dose every 3-12 months. Scabies: 200 mcg/kg as a single oral dose, repeated after 7-14 days if needed.
Elderly
No specific dosage adjustment is generally required unless hepatic or renal impairment is present. Use with caution due to potential age-related decrease in organ function.
Renal_impairment
Use with caution in patients with severe renal impairment (CrCl <30 mL/min); dosage adjustment may be necessary. Not dialyzable.
How to Take
Administer orally with water. For Strongyloidiasis and Scabies, it may be taken with food to enhance absorption. For Onchocerciasis, it is typically taken on an empty stomach to reduce variability.
Mechanism of Action
Ivermectin binds selectively and with high affinity to glutamate-gated chloride ion channels, which occur in invertebrate nerve and muscle cells. This binding leads to an increase in the permeability of the cell membrane to chloride ions, resulting in hyperpolarization of the nerve or muscle cell, leading to paralysis and death of the parasite.
Pharmacokinetics
Onset
Varies by condition, generally within days to weeks for therapeutic effect.
Excretion
Mainly through feces as unchanged drug and metabolites; less than 1% excreted in urine.
Half life
Approximately 12-36 hours.
Absorption
Rapidly absorbed after oral administration, peak plasma concentrations reached in approximately 4-5 hours. Bioavailability is increased with a high-fat meal.
Metabolism
Primarily hepatic, via cytochrome P450 3A4.
Side Effects
Contraindications
- Hypersensitivity to ivermectin or any component of the formulation.
- Children weighing less than 15 kg (or under 5 years of age).
- Conditions that impair the blood-brain barrier (e.g., meningitis) due to potential for increased central nervous system exposure.
Drug Interactions
Warfarin
Ivermectin may potentiate the anticoagulant effect of warfarin. Monitor INR closely.
CNS depressants (e.g., benzodiazepines, barbiturates, alcohol)
May enhance CNS depressant effects, increasing risk of dizziness or drowsiness.
Storage
Store below 30°C in a dry place, away from direct light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include rash, edema, headache, dizziness, nausea, vomiting, diarrhea, abdominal pain, asthenia, seizures, and coma. Treatment is supportive; general supportive measures, including parenteral fluids and electrolytes, respiratory support, and pressor agents if necessary, should be initiated.
Pregnancy & Lactation
Pregnancy Category C. Not recommended during pregnancy unless the potential benefits justify the potential risk to the fetus. Small amounts are excreted in breast milk; caution is advised when administering to breastfeeding mothers.
Side Effects
Contraindications
- Hypersensitivity to ivermectin or any component of the formulation.
- Children weighing less than 15 kg (or under 5 years of age).
- Conditions that impair the blood-brain barrier (e.g., meningitis) due to potential for increased central nervous system exposure.
Drug Interactions
Warfarin
Ivermectin may potentiate the anticoagulant effect of warfarin. Monitor INR closely.
CNS depressants (e.g., benzodiazepines, barbiturates, alcohol)
May enhance CNS depressant effects, increasing risk of dizziness or drowsiness.
Storage
Store below 30°C in a dry place, away from direct light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include rash, edema, headache, dizziness, nausea, vomiting, diarrhea, abdominal pain, asthenia, seizures, and coma. Treatment is supportive; general supportive measures, including parenteral fluids and electrolytes, respiratory support, and pressor agents if necessary, should be initiated.
Pregnancy & Lactation
Pregnancy Category C. Not recommended during pregnancy unless the potential benefits justify the potential risk to the fetus. Small amounts are excreted in breast milk; caution is advised when administering to breastfeeding mothers.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24 to 36 months from the date of manufacture.
Availability
Pharmacies nationwide
Approval Status
Approved by regulatory authorities (e.g., DGDA, FDA)
Patent Status
Generic available
WHO Essential Medicine
YesClinical Trials
Ivermectin has undergone extensive clinical trials for its approved parasitic indications. Ongoing research explores its potential in other areas, but these are not yet approved indications.
Lab Monitoring
- Liver function tests (periodically, especially with prolonged use or pre-existing hepatic impairment).
- Complete blood count (in patients with certain parasitic infections, e.g., Onchocerciasis, for eosinophilia).
Doctor Notes
- Ensure accurate diagnosis of parasitic infection before prescribing.
- Educate patients on potential Mazzotti reaction when treating onchocerciasis.
- Monitor patients for signs of CNS effects, especially if blood-brain barrier is compromised.
Patient Guidelines
- Complete the full course of medication as prescribed, even if symptoms improve to ensure complete eradication of parasites.
- Inform your doctor about all other medications, including herbal supplements, you are taking.
- Report any severe or persistent side effects, especially dizziness, changes in vision, or skin reactions.
- Do not crush or chew the tablet; swallow it whole with water.
Missed Dose Advice
As this is often a single-dose treatment or administered infrequently, if a dose is missed for multi-dose regimens, take it as soon as remembered. Do not double dose to catch up.
Driving Precautions
Ivermectin may cause dizziness, drowsiness, or visual disturbances in some patients. Advise caution when driving or operating machinery until you know how the medicine affects you.
Lifestyle Advice
- Maintain good personal hygiene, including frequent handwashing and proper disposal of waste, to prevent reinfection.
- For scabies or lice, follow specific hygiene measures as advised by your doctor, which may include washing clothes and bedding in hot water.
- Avoid close contact with infected individuals during treatment for highly contagious conditions like scabies.
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