Ectover
Generic Name
Ivermectin
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| ectover 6 mg tablet | ৳ 10.00 | ৳ 100.00 |
Description
Overview of the medicine
Ivermectin is an anti-parasitic medication used to treat certain parasitic infections, including strongyloidiasis, onchocerciasis, and scabies. It belongs to the avermectin class of drugs.
Uses & Indications
Dosage
Adults
For strongyloidiasis: A single oral dose of 200 mcg/kg body weight. For onchocerciasis: A single oral dose of 150 mcg/kg body weight, repeated every 6-12 months. For scabies: A single oral dose of 200 mcg/kg body weight, repeated after 7-14 days.
Elderly
No specific dosage adjustment required for elderly patients based solely on age, but consider overall health, renal, and hepatic function.
Renal_impairment
Use with caution in severe renal impairment. No specific dose adjustment guidelines are established for mild to moderate impairment, but monitoring is advised.
How to Take
Administer orally with water on an empty stomach, usually 30 minutes before food. This helps to ensure optimal absorption.
Mechanism of Action
Ivermectin binds selectively and with high affinity to glutamate-gated chloride ion channels which occur in invertebrate nerve and muscle cells. This leads to an increase in the permeability of the cell membrane to chloride ions, resulting in hyperpolarization of the nerve or muscle cell, and subsequent paralysis and death of the parasite.
Pharmacokinetics
Onset
Onset of action varies depending on the parasitic infection, often within days to weeks for therapeutic effects.
Excretion
Primarily excreted in feces (approximately 98%), almost exclusively as metabolites. Less than 1% of the administered dose is excreted in urine.
Half life
The plasma elimination half-life is approximately 16 hours for a single 12 mg oral dose.
Absorption
Well absorbed orally. Peak plasma concentrations are reached approximately 4 hours after administration. Bioavailability is increased when taken with a fatty meal.
Metabolism
Extensively metabolized in the liver, primarily by cytochrome P450 3A4 (CYP3A4) isoenzyme. Several metabolites have been identified.
Side Effects
Contraindications
- Known hypersensitivity to Ivermectin or any component of the formulation.
- Patients with impaired liver function or kidney disease should use with caution and under medical supervision.
- Not for use in children weighing less than 15 kg (or as specified by local guidelines).
Drug Interactions
Warfarin
May enhance the anticoagulant effect; monitor INR closely.
CYP3A4 inhibitors/inducers
Ivermectin is metabolized by CYP3A4, so drugs affecting this enzyme may alter its plasma concentrations.
Other CNS depressants (e.g., benzodiazepines, barbiturates)
May potentiate CNS depression, leading to increased drowsiness or dizziness.
Storage
Store below 30°C in a dry place, away from direct sunlight and moisture. Keep out of reach and sight of children.
Overdose
Symptoms of overdose may include rash, edema, headache, dizziness, asthenia, nausea, vomiting, diarrhea, abdominal pain, and rarely, seizures or coma. Management is symptomatic and supportive, including fluid and electrolyte replacement, and if necessary, parental support of respiration and blood pressure.
Pregnancy & Lactation
Ivermectin is generally not recommended during pregnancy unless the potential benefit justifies the potential risk to the fetus, especially during the first trimester. Small amounts are excreted in breast milk; caution is advised, or avoid breastfeeding for 12 hours after treatment to minimize infant exposure.
Side Effects
Contraindications
- Known hypersensitivity to Ivermectin or any component of the formulation.
- Patients with impaired liver function or kidney disease should use with caution and under medical supervision.
- Not for use in children weighing less than 15 kg (or as specified by local guidelines).
Drug Interactions
Warfarin
May enhance the anticoagulant effect; monitor INR closely.
CYP3A4 inhibitors/inducers
Ivermectin is metabolized by CYP3A4, so drugs affecting this enzyme may alter its plasma concentrations.
Other CNS depressants (e.g., benzodiazepines, barbiturates)
May potentiate CNS depression, leading to increased drowsiness or dizziness.
Storage
Store below 30°C in a dry place, away from direct sunlight and moisture. Keep out of reach and sight of children.
Overdose
Symptoms of overdose may include rash, edema, headache, dizziness, asthenia, nausea, vomiting, diarrhea, abdominal pain, and rarely, seizures or coma. Management is symptomatic and supportive, including fluid and electrolyte replacement, and if necessary, parental support of respiration and blood pressure.
Pregnancy & Lactation
Ivermectin is generally not recommended during pregnancy unless the potential benefit justifies the potential risk to the fetus, especially during the first trimester. Small amounts are excreted in breast milk; caution is advised, or avoid breastfeeding for 12 hours after treatment to minimize infant exposure.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24 to 36 months from the manufacturing date, as indicated on the packaging.
Availability
Pharmacies, Hospitals
Approval Status
Approved by regulatory authorities (e.g., DGDA in Bangladesh)
Patent Status
Generic available
WHO Essential Medicine
YesClinical Trials
Ivermectin has undergone extensive clinical trials demonstrating its efficacy and safety for various parasitic infections. Ongoing research explores its potential in other diseases, though not yet approved for those indications.
Lab Monitoring
- No routine lab monitoring is generally required for healthy individuals receiving Ivermectin for parasitic infections. In patients with underlying liver disease, liver function tests may be monitored.
Doctor Notes
- Confirm parasitic diagnosis prior to prescribing, especially differentiating between various helminthic infections.
- Educate patients about the importance of proper administration (empty stomach) and potential Mazzotti reactions in onchocerciasis.
- Monitor for adverse reactions, particularly in immunocompromised patients or those with underlying liver disease.
- Advise patients on hygiene measures to prevent reinfection.
Patient Guidelines
- Take the medicine exactly as prescribed by your doctor.
- Report any severe or persistent side effects to your healthcare provider immediately.
- Do not share this medicine with others, even if they have similar symptoms.
- Complete the full course of treatment, even if you feel better, to ensure eradication of the parasite.
Missed Dose Advice
Since Ectover is often a single dose treatment or a short course, take the missed dose as soon as you remember. If it is almost time for your next scheduled dose, skip the missed dose and resume your regular dosing schedule. Do not take a double dose to make up for a missed one. Consult your doctor if you are unsure.
Driving Precautions
Ectover may cause dizziness or drowsiness in some individuals. Patients should exercise caution when driving or operating machinery until they know how the medication affects them.
Lifestyle Advice
- Maintain good personal hygiene, especially handwashing, to prevent reinfection, particularly for parasitic worm infections. For scabies, ensure thorough cleaning and washing of clothing and bedding.
- Avoid close contact with infected individuals to prevent transmission.
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