Edenil
Generic Name
Esomeprazole
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| edenil 40 mg tablet | ৳ 10.00 | ৳ 100.00 |
Description
Overview of the medicine
Edenil 40 mg Tablet contains Esomeprazole, which is used to reduce the amount of acid produced in the stomach. It treats conditions caused by too much stomach acid.
Uses & Indications
Dosage
Adults
20 mg or 40 mg once daily, depending on the indication and severity. For erosive esophagitis, typically 40 mg once daily for 4-8 weeks. For GERD symptoms, 20 mg once daily.
Elderly
No dosage adjustment is generally required for elderly patients.
Renal_impairment
No dosage adjustment is necessary for patients with impaired renal function.
How to Take
Take Edenil 40 mg Tablet orally, usually once daily, at least one hour before a meal. Do not crush, chew, or split the tablet; swallow it whole with water.
Mechanism of Action
Esomeprazole is a proton pump inhibitor that works by irreversibly blocking the H+/K+-ATPase enzyme system (the proton pump) in the gastric parietal cells. This action inhibits the final step in gastric acid production, leading to a reduction in both basal and stimulated acid secretion.
Pharmacokinetics
Onset
Acid suppression occurs within 1 hour after a single oral dose.
Excretion
Approximately 80% of a dose is excreted as metabolites in the urine, and the remainder in the feces.
Half life
The plasma elimination half-life is approximately 1-1.5 hours.
Absorption
Rapidly absorbed after oral administration. Bioavailability is approximately 50-60% after a single 40 mg dose, increasing with repeated dosing.
Metabolism
Extensively metabolized in the liver by the cytochrome P450 (CYP) enzyme system, primarily by CYP2C19 and CYP3A4.
Side Effects
Contraindications
- Hypersensitivity to esomeprazole, substituted benzimidazoles, or any component of the formulation.
- Concomitant use with nelfinavir.
Drug Interactions
Warfarin
Increased INR and prothrombin time.
Clopidogrel
Reduced antiplatelet efficacy of clopidogrel.
Methotrexate
Increased methotrexate levels.
Nelfinavir/Atazanavir
Reduced plasma levels of nelfinavir and atazanavir, leading to loss of virologic response.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Limited experience with overdose. Symptoms can include drowsiness, confusion, blurred vision, tachycardia, nausea, sweating, headache, dry mouth. Treatment is symptomatic and supportive.
Pregnancy & Lactation
Pregnancy Category C. Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. Esomeprazole is excreted in human milk; caution should be exercised when administered to a nursing woman.
Side Effects
Contraindications
- Hypersensitivity to esomeprazole, substituted benzimidazoles, or any component of the formulation.
- Concomitant use with nelfinavir.
Drug Interactions
Warfarin
Increased INR and prothrombin time.
Clopidogrel
Reduced antiplatelet efficacy of clopidogrel.
Methotrexate
Increased methotrexate levels.
Nelfinavir/Atazanavir
Reduced plasma levels of nelfinavir and atazanavir, leading to loss of virologic response.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Limited experience with overdose. Symptoms can include drowsiness, confusion, blurred vision, tachycardia, nausea, sweating, headache, dry mouth. Treatment is symptomatic and supportive.
Pregnancy & Lactation
Pregnancy Category C. Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. Esomeprazole is excreted in human milk; caution should be exercised when administered to a nursing woman.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months from the date of manufacture.
Availability
Pharmacies nationwide
Approval Status
Approved by DGDA
Patent Status
Generic available
WHO Essential Medicine
YesClinical Trials
Esomeprazole has undergone extensive clinical trials demonstrating its efficacy and safety in various acid-related disorders, including GERD, erosive esophagitis, and peptic ulcer disease. Studies have confirmed its superiority or non-inferiority compared to other PPIs in certain indications.
Lab Monitoring
- For prolonged use (over 1 year), monitor serum magnesium levels, especially in patients taking diuretics or other medications that can cause hypomagnesemia.
- Liver function tests may be considered in patients with severe hepatic impairment.
Doctor Notes
- Consider step-down therapy or intermittent dosing for long-term management of GERD.
- Monitor magnesium levels in patients on prolonged therapy, especially with concomitant diuretic use.
- Advise patients on lifestyle modifications to complement drug therapy.
Patient Guidelines
- Take the medicine exactly as prescribed by your doctor.
- Do not crush or chew the tablet; swallow it whole.
- Report any severe or persistent side effects to your doctor.
- Do not stop taking Edenil 40 mg suddenly without consulting your doctor, as this may worsen your condition.
- Inform your doctor about all other medications you are taking, including over-the-counter drugs and herbal supplements.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and take your next dose at the regular time. Do not double the dose to catch up.
Driving Precautions
Esomeprazole is not expected to affect the ability to drive or operate machinery. However, if side effects like dizziness or blurred vision occur, avoid driving or operating machinery.
Lifestyle Advice
- Avoid trigger foods such as spicy foods, acidic foods, caffeine, and fatty meals.
- Avoid alcohol and smoking, as they can exacerbate acid reflux.
- Eat smaller, more frequent meals.
- Elevate the head of your bed to reduce nighttime reflux symptoms.
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