Editoren
Generic Name
editoren-200-mg-tablet
Manufacturer
Aristopharma Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| editoren 200 mg tablet | ৳ 150.00 | ৳ 600.00 |
Description
Overview of the medicine
Acyclovir is an antiviral drug used to treat infections caused by herpes simplex virus (HSV) and varicella-zoster virus (VZV), including genital herpes, cold sores, shingles, and chickenpox. It works by stopping the spread of the virus in the body.
Uses & Indications
Dosage
Adults
Genital Herpes (Initial): 200 mg five times daily for 5-10 days. Recurrent Genital Herpes: 200 mg five times daily for 5 days, or 400 mg three times daily for 5 days. Herpes Zoster (Shingles): 800 mg five times daily for 7-10 days. Varicella (Chickenpox): 800 mg four times daily for 5 days.
Elderly
Dosage adjustments may be necessary based on renal function; monitor renal status.
Renal_impairment
Reduced dosage and/or extended dosing interval required based on creatinine clearance (e.g., CrCl < 10 mL/min, 200 mg every 12 hours).
How to Take
Take orally with or without food. Ensure adequate hydration during treatment, especially with high doses or in renally impaired patients, to prevent renal crystalluria.
Mechanism of Action
Acyclovir is a synthetic purine nucleoside analogue with in vitro and in vivo inhibitory activity against human herpes viruses. It is converted to acyclovir triphosphate, which inhibits viral DNA synthesis by acting as a competitive substrate for viral DNA polymerase and by chain termination after its incorporation into viral DNA.
Pharmacokinetics
Onset
Varies depending on the infection type and severity, typically symptomatic relief within 24-72 hours.
Excretion
Primarily renal excretion, with the majority of the drug eliminated unchanged via glomerular filtration and tubular secretion.
Half life
2.5-3.3 hours in adults with normal renal function.
Absorption
Poor oral absorption (15-30%); food does not significantly affect absorption.
Metabolism
Partially metabolized in the liver to 9-carboxymethoxymethylguanine (an inactive metabolite).
Side Effects
Contraindications
- •Hypersensitivity to acyclovir or valacyclovir.
Drug Interactions
Probenecid
Increases acyclovir plasma concentrations and prolongs its half-life by reducing renal clearance.
Nephrotoxic drugs
Concurrent use with other nephrotoxic agents may increase the risk of renal dysfunction. Close monitoring is advised.
Mycophenolate Mofetil
Co-administration may increase plasma concentrations of both acyclovir and the inactive metabolite of mycophenolate mofetil.
Storage
Store below 30°C in a dry place, away from direct light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include increased serum creatinine and blood urea nitrogen, renal failure, lethargy, confusion, hallucinations, and seizures. Management involves symptomatic and supportive care. Hemodialysis can significantly enhance the removal of acyclovir from the blood.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have not shown a risk, but human studies are lacking. Use only if clearly needed. Excreted in breast milk; use with caution during lactation.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from the date of manufacture, specific expiry date is printed on the pack.
Availability
Pharmacies, Hospitals
Approval Status
Approved
Patent Status
Generic available
WHO Essential Medicine
YesAlternative Medicines in Bangladesh
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Global Brand Names
International brand names for this medicine
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