Emfogen-M-XR
Generic Name
Memantine Hydrochloride Extended-Release Tablet
Manufacturer
Hypothetical Pharma Co.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| emfogen m xr 5 mg tablet | ৳ 20.00 | ৳ 120.00 |
Description
Overview of the medicine
Emfogen-M-XR is an N-methyl-D-aspartate (NMDA) receptor antagonist used for the treatment of moderate-to-severe Alzheimer's disease. It helps to improve memory, awareness, and the ability to perform daily functions.
Uses & Indications
Dosage
Adults
Initial dose is 7 mg once daily (if starting from 0 mg). For Emfogen-M-XR 5 mg, it might be used as part of a titration schedule or maintenance dose depending on patient tolerance and previous treatment. Typical maintenance is 14-28 mg once daily.
Elderly
No specific dose adjustment required, but close monitoring is recommended.
Renal_impairment
Moderate renal impairment (CrCl 30-49 mL/min): maximum recommended dose is 14 mg once daily. Severe renal impairment (CrCl 5-29 mL/min): maximum recommended dose is 7 mg once daily.
How to Take
Take orally once daily with or without food. Swallow the tablet whole; do not crush, chew, or divide.
Mechanism of Action
Memantine is an NMDA receptor antagonist that binds to the NMDA receptor-operated cation channels. It blocks the effects of abnormal glutamate, an excitatory neurotransmitter that may contribute to the symptoms of Alzheimer's disease.
Pharmacokinetics
Onset
Clinical effects observed within weeks.
Excretion
Primarily excreted unchanged in urine.
Half life
Approximately 60-80 hours.
Absorption
Well absorbed from the gastrointestinal tract; Cmax is reached in 9-12 hours for XR.
Metabolism
Limited hepatic metabolism; some metabolites formed.
Side Effects
Contraindications
- Hypersensitivity to memantine or any component of the formulation.
Drug Interactions
NMDA antagonists (e.g., amantadine, ketamine, dextromethorphan)
Concomitant use may increase the frequency and severity of adverse reactions.
Drugs that increase urinary pH (e.g., carbonic anhydrase inhibitors, sodium bicarbonate)
May decrease memantine clearance, leading to increased plasma levels.
Storage
Store at room temperature (20°C to 25°C), away from moisture and direct light. Keep out of reach of children.
Overdose
Symptoms may include agitation, confusion, hallucinations, somnolence, stupor, and seizures. Management is supportive and symptomatic.
Pregnancy & Lactation
Pregnancy Category B. Use only if clearly needed. It is unknown whether memantine is excreted in human milk. Exercise caution.
Side Effects
Contraindications
- Hypersensitivity to memantine or any component of the formulation.
Drug Interactions
NMDA antagonists (e.g., amantadine, ketamine, dextromethorphan)
Concomitant use may increase the frequency and severity of adverse reactions.
Drugs that increase urinary pH (e.g., carbonic anhydrase inhibitors, sodium bicarbonate)
May decrease memantine clearance, leading to increased plasma levels.
Storage
Store at room temperature (20°C to 25°C), away from moisture and direct light. Keep out of reach of children.
Overdose
Symptoms may include agitation, confusion, hallucinations, somnolence, stupor, and seizures. Management is supportive and symptomatic.
Pregnancy & Lactation
Pregnancy Category B. Use only if clearly needed. It is unknown whether memantine is excreted in human milk. Exercise caution.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24-36 months from manufacturing date.
Availability
Pharmacies, Hospitals
Approval Status
FDA Approved
Patent Status
Patent Expired for Generic Memantine, Brand might have new formulation patent
Clinical Trials
Numerous clinical trials have demonstrated the efficacy and safety of memantine in improving cognitive and functional outcomes in patients with moderate-to-severe Alzheimer's disease.
Lab Monitoring
- Renal function should be monitored periodically, especially in patients with pre-existing renal impairment.
Doctor Notes
- Advise caregivers on potential side effects and when to seek medical attention.
- Regular assessment of patient's cognitive and functional status is crucial.
Patient Guidelines
- Take as directed by your doctor.
- Do not stop taking the medicine suddenly without consulting your doctor.
- Inform your doctor about all other medications you are taking.
Missed Dose Advice
If a dose is missed, skip the missed dose and take the next dose at the regular scheduled time. Do not take two doses at the same time.
Driving Precautions
This medicine may cause dizziness or confusion. Do not drive or operate heavy machinery until you know how it affects you.
Lifestyle Advice
- Maintain a healthy diet and regular exercise as advised by your healthcare provider.
- Stay mentally and socially active.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
Other Medicines in Emfogen-M-XR Brand
Other medicines available under the same brand name
Emfogen-M XR
Extended-Release Tablet
Emfogen-M XR
Extended-release Tablet