Empavic
Generic Name
Empagliflozin
Manufacturer
Hypothetical Manufacturer (e.g., Square Pharmaceuticals Ltd.)
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| empavic 10 mg tablet | ৳ 25.00 | ৳ 250.00 |
Description
Overview of the medicine
Empagliflozin is an oral antidiabetic drug used for the treatment of type 2 diabetes mellitus. It belongs to the SGLT2 inhibitor class, working by increasing glucose excretion in the urine. It is also approved for reducing the risk of cardiovascular death, hospitalization for heart failure, and slowing the progression of kidney disease in specific patient populations.
Uses & Indications
Dosage
Adults
The recommended starting dose is 10 mg once daily in the morning, with or without food. The dose may be increased to 25 mg once daily based on glycemic response and tolerability, if additional glycemic control is needed. For heart failure and chronic kidney disease indications, the recommended dose is 10 mg once daily.
Elderly
No dosage adjustment is recommended based on age. However, renal function should be assessed before initiating Empagliflozin and monitored periodically during treatment.
Renal_impairment
For type 2 diabetes and heart failure, Empagliflozin is not recommended for initiation in patients with an eGFR less than 30 mL/min/1.73m². For chronic kidney disease, Empagliflozin can be initiated in patients with an eGFR as low as 20 mL/min/1.73m².
How to Take
Take orally once daily in the morning, with or without food.
Mechanism of Action
Empagliflozin inhibits the sodium-glucose co-transporter 2 (SGLT2) in the renal proximal tubules, leading to reduced reabsorption of glucose from the glomerular filtrate and increased urinary glucose excretion. This results in lowered blood glucose levels, independent of insulin secretion or sensitivity.
Pharmacokinetics
Onset
Glucose-lowering effects typically observed within hours of administration.
Excretion
Approximately 50% of the dose is excreted via the urine (as unchanged drug and metabolites) and approximately 50% via the feces (mainly as unchanged drug).
Half life
The terminal elimination half-life is approximately 12.4 hours.
Absorption
Rapidly absorbed after oral administration. Peak plasma concentrations (Cmax) are reached approximately 1.5 hours post-dose. Absolute bioavailability is approximately 78%.
Metabolism
Primarily metabolized by glucuronidation via UDP-glucuronosyltransferases UGT1A8, UGT1A3, UGT1A9, and UGT2B7.
Side Effects
Contraindications
- •Hypersensitivity to empagliflozin or any excipients.
- •Severe renal impairment (eGFR <30 mL/min/1.73m²), end-stage renal disease, or patients on dialysis for glycemic control in type 2 diabetes and heart failure. For chronic kidney disease, avoid if eGFR <20 mL/min/1.73m².
Drug Interactions
Lithium
May decrease serum lithium concentrations.
Diuretics
May increase the risk of dehydration and hypotension.
Insulin and Insulin Secretagogues (e.g., Sulfonylureas)
Increased risk of hypoglycemia when used concomitantly. A lower dose of insulin or insulin secretagogue may be required.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
In the event of an overdose, there is no specific antidote. Treatment should be supportive, initiating symptomatic and supportive measures as appropriate for the patient’s clinical status.
Pregnancy & Lactation
Not recommended during the second and third trimesters of pregnancy due to potential for adverse effects on renal development. Avoid during lactation as it is unknown if empagliflozin is excreted in human milk.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 to 36 months from the date of manufacture, depending on manufacturer specifications.
Availability
Available in pharmacies worldwide
Approval Status
FDA Approved, DGDA Approved
Patent Status
Patented by Boehringer Ingelheim / Eli Lilly
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Global Brand Names
International brand names for this medicine
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