Empavic
Generic Name
Empagliflozin
Manufacturer
Example Pharma Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| empavic 25 mg tablet | ৳ 40.00 | ৳ 400.00 |
Description
Overview of the medicine
Empavic 25 mg Tablet contains Empagliflozin, an SGLT2 inhibitor used to treat type 2 diabetes mellitus, reduce the risk of cardiovascular death in adults with type 2 diabetes and established cardiovascular disease, and reduce the risk of cardiovascular death and hospitalization for heart failure in adults with heart failure. It works by causing the kidneys to remove sugar from the body through the urine.
Uses & Indications
Dosage
Adults
Initial dose is 10 mg once daily, taken in the morning, with or without food. May be increased to 25 mg once daily based on glycemic control and tolerability.
Elderly
No dose adjustment is recommended based on age alone. Renal function should be assessed before initiation.
Renal_impairment
Initiation not recommended in patients with eGFR < 20 mL/min/1.73 m². For patients already on empagliflozin, continue at 10 mg or 25 mg down to eGFR of 20 mL/min/1.73 m².
How to Take
Take orally once daily in the morning, with or without food.
Mechanism of Action
Empagliflozin inhibits the sodium-glucose co-transporter 2 (SGLT2) in the renal proximal tubules. SGLT2 is responsible for at least 90% of the reabsorption of filtered glucose from the tubular lumen. By inhibiting SGLT2, empagliflozin reduces glucose reabsorption and lowers the renal threshold for glucose, leading to increased urinary glucose excretion and subsequently lower blood glucose levels. This also results in osmotic diuresis, natriuresis, and reduced preload and afterload, contributing to its cardiovascular and renal benefits.
Pharmacokinetics
Onset
Glucose-lowering effect typically observed within hours of the first dose.
Excretion
Approximately 50% renally excreted and 50% hepatically excreted (mainly via feces, as unchanged drug or metabolites).
Half life
Approximately 12.4 hours.
Absorption
Rapidly absorbed after oral administration, with peak plasma concentrations (Cmax) reached approximately 1.5 hours post-dose. Bioavailability is about 78%.
Metabolism
Primarily metabolized by glucuronidation via UDP-glucuronosyltransferases UGT1A3, UGT1A8, UGT1A9, and UGT2B7. Not a significant substrate, inhibitor, or inducer of CYP450 enzymes.
Side Effects
Contraindications
- •Hypersensitivity to empagliflozin or any component of the tablet
- •Severe renal impairment (eGFR < 20 mL/min/1.73 m²) or end-stage renal disease (ESRD)
- •Patients on dialysis
Drug Interactions
Lithium
Empagliflozin may decrease lithium levels due to increased urinary excretion.
Diuretics
Increased risk of dehydration and hypotension.
Rifampicin/Other UGT Inducers
May decrease empagliflozin exposure.
Insulin or Insulin Secretagogues
Increased risk of hypoglycemia; may require dose adjustment of insulin/secretagogue.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
In case of overdose, no specific antidote is available. Treatment should be supportive and symptomatic. Hemodialysis is not expected to remove empagliflozin significantly.
Pregnancy & Lactation
Pregnancy Category D. Not recommended during pregnancy, especially during the second and third trimesters. Risk of adverse renal effects in the developing fetus. Avoid during breastfeeding due to unknown excretion in human milk and potential for adverse effects on the infant.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24-36 months from manufacturing date.
Availability
Pharmacies, hospitals, clinics
Approval Status
FDA Approved, DGDA Approved
Patent Status
Patent held by original innovator (Boehringer Ingelheim & Eli Lilly and Company), generic versions may be available in some regions.
WHO Essential Medicine
YesAlternative Medicines in Bangladesh
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Global Brand Names
International brand names for this medicine
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