Enar
Generic Name
Enaroxacin
Manufacturer
PharmaCorp Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| enar 375 mg tablet | ৳ 12.00 | ৳ 48.00 |
Description
Overview of the medicine
Enar 375 mg Tablet is a broad-spectrum antibiotic used to treat various bacterial infections, including respiratory tract infections, urinary tract infections, and skin and soft tissue infections. It belongs to the quinolone class of antibiotics.
Uses & Indications
Dosage
Adults
375 mg once daily or 187.5 mg twice daily for 7 to 14 days, depending on the severity and type of infection. For uncomplicated UTIs, a 3-day course may be sufficient.
Elderly
No specific dose adjustment is generally required for elderly patients unless there is significant renal impairment.
Renal_impairment
Dose adjustment necessary for patients with creatinine clearance < 50 mL/min. For CrCl 30-49 mL/min, 187.5 mg once daily; for CrCl < 30 mL/min, 187.5 mg every 48 hours.
How to Take
May be taken with or without food. Swallow the tablet whole with a glass of water. Do not crush, cut, or chew the tablet. It is important to complete the entire prescribed course of treatment.
Mechanism of Action
Enaroxacin acts by inhibiting bacterial DNA gyrase and topoisomerase IV, essential enzymes involved in DNA replication, transcription, repair, and recombination. This leads to disruption of bacterial DNA and cell death.
Pharmacokinetics
Onset
Within 1-2 hours of oral administration.
Excretion
Mainly renal excretion (60-70% as unchanged drug), with some fecal elimination.
Half life
Approximately 6-8 hours, allowing for once or twice daily dosing.
Absorption
Rapidly absorbed from the gastrointestinal tract; high oral bioavailability (approx. 80-90%). Peak plasma concentrations are reached within 1-2 hours.
Metabolism
Primarily hepatic metabolism to less active metabolites, though a significant portion remains unchanged.
Side Effects
Contraindications
- Known hypersensitivity to Enaroxacin, other quinolones, or any component of the formulation.
- History of tendinitis or tendon rupture associated with quinolone use.
- Patients with myasthenia gravis due to potential exacerbation of muscle weakness.
- Children and adolescents under 18 years of age (due to risk of cartilage damage).
Drug Interactions
Warfarin
May enhance the anticoagulant effect of warfarin, requiring monitoring of INR and dose adjustment.
Theophylline
May increase serum concentrations of theophylline, leading to increased risk of toxicity. Monitor theophylline levels.
Corticosteroids
Concomitant use increases the risk of tendinitis and tendon rupture.
Anti-arrhythmics (Class IA and III)
May increase the risk of QT prolongation. Avoid co-administration if possible.
Antacids, iron supplements, zinc supplements, sucralfate
May significantly decrease the absorption of Enaroxacin. Administer Enaroxacin at least 2 hours before or 6 hours after these agents.
Storage
Store below 30°C in a dry place, away from direct light and moisture. Keep out of reach and sight of children.
Overdose
In case of an overdose, seek immediate medical attention or contact a poison control center. Symptoms may include nausea, vomiting, diarrhea, dizziness, confusion, seizures, and QT prolongation. Management is symptomatic and supportive, including gastric lavage or induced emesis, ensuring adequate hydration, and monitoring ECG and vital signs.
Pregnancy & Lactation
Pregnancy Category C. Enaroxacin should not be used during pregnancy unless the potential benefit justifies the potential risk to the fetus, as animal studies have shown potential for harm. It is excreted into breast milk and therefore not recommended during lactation due to potential adverse effects on the nursing infant, including cartilage damage.
Side Effects
Contraindications
- Known hypersensitivity to Enaroxacin, other quinolones, or any component of the formulation.
- History of tendinitis or tendon rupture associated with quinolone use.
- Patients with myasthenia gravis due to potential exacerbation of muscle weakness.
- Children and adolescents under 18 years of age (due to risk of cartilage damage).
Drug Interactions
Warfarin
May enhance the anticoagulant effect of warfarin, requiring monitoring of INR and dose adjustment.
Theophylline
May increase serum concentrations of theophylline, leading to increased risk of toxicity. Monitor theophylline levels.
Corticosteroids
Concomitant use increases the risk of tendinitis and tendon rupture.
Anti-arrhythmics (Class IA and III)
May increase the risk of QT prolongation. Avoid co-administration if possible.
Antacids, iron supplements, zinc supplements, sucralfate
May significantly decrease the absorption of Enaroxacin. Administer Enaroxacin at least 2 hours before or 6 hours after these agents.
Storage
Store below 30°C in a dry place, away from direct light and moisture. Keep out of reach and sight of children.
Overdose
In case of an overdose, seek immediate medical attention or contact a poison control center. Symptoms may include nausea, vomiting, diarrhea, dizziness, confusion, seizures, and QT prolongation. Management is symptomatic and supportive, including gastric lavage or induced emesis, ensuring adequate hydration, and monitoring ECG and vital signs.
Pregnancy & Lactation
Pregnancy Category C. Enaroxacin should not be used during pregnancy unless the potential benefit justifies the potential risk to the fetus, as animal studies have shown potential for harm. It is excreted into breast milk and therefore not recommended during lactation due to potential adverse effects on the nursing infant, including cartilage damage.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months from the date of manufacture when stored under recommended conditions.
Availability
Pharmacies nationwide
Approval Status
Approved by local regulatory authority
Patent Status
Under patent protection
Clinical Trials
Enaroxacin has undergone extensive Phase III clinical trials demonstrating its efficacy and safety in treating a variety of bacterial infections, including those resistant to older antibiotics. Post-marketing surveillance is ongoing.
Lab Monitoring
- Renal function tests (blood urea nitrogen, serum creatinine) in patients with pre-existing impairment or elderly.
- Liver function tests (ALT, AST) for prolonged therapy or in patients with liver conditions.
- Blood glucose levels in diabetic patients, especially those on oral hypoglycemic agents or insulin.
Doctor Notes
- Emphasize patient education regarding the importance of completing the full antibiotic course to prevent resistance.
- Be vigilant for signs of tendinopathy, peripheral neuropathy, or CNS disturbances, especially in at-risk patients (elderly, corticosteroid users).
- Advise patients to report any severe or unusual symptoms immediately.
- Consider drug interactions carefully, particularly with antacids, warfarin, and theophylline.
Patient Guidelines
- Complete the full course of treatment as prescribed by your doctor, even if your symptoms improve.
- Avoid excessive exposure to sunlight or artificial UV light, and use protective clothing and sunscreen.
- Report any pain, swelling, or inflammation of a tendon (especially in the heel, shoulder, or hand) immediately.
- Inform your doctor if you experience any signs of nerve damage (e.g., pain, burning, tingling, numbness, weakness).
Missed Dose Advice
If a dose is missed, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Enaroxacin may cause dizziness, lightheadedness, or visual disturbances. Patients should be advised to exercise caution when driving or operating machinery until they know how the medication affects them.
Lifestyle Advice
- Maintain good hydration by drinking plenty of fluids throughout the day.
- Avoid alcohol consumption as it may worsen some side effects.
- Follow a balanced diet rich in vitamins and minerals to support recovery.
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