Enar
Generic Name
Enar
Manufacturer
MediCorp Pharma
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| enar 500 mg tablet | ৳ 13.00 | ৳ 130.00 |
Description
Overview of the medicine
Enar 500 mg Tablet is a synthetic broad-spectrum antibiotic from the fluoroquinolone class, primarily used to treat various bacterial infections throughout the body.
Uses & Indications
Dosage
Adults
Typically 500 mg orally twice daily for 7 to 14 days, depending on the severity and type of infection. Dosage and duration may vary.
Elderly
No specific dosage adjustment is required for elderly patients with normal renal function. Dosage should be adjusted based on renal impairment.
Renal_impairment
For creatinine clearance <30 mL/min, reduce the dose (e.g., 250-500 mg once daily) or increase the dosing interval. Consult a doctor for specific guidance.
How to Take
Enar tablets should be swallowed whole with a glass of water, with or without food. Do not chew or crush the tablet. It should not be taken with dairy products or calcium-fortified juices, or antacids.
Mechanism of Action
Enar works by inhibiting bacterial DNA gyrase and topoisomerase IV, enzymes essential for bacterial DNA replication, transcription, repair, and recombination. This leads to cell death of susceptible bacteria.
Pharmacokinetics
Onset
Within 1-2 hours
Excretion
Primarily excreted renally (approximately 50-70% as unchanged drug) and to a lesser extent via feces.
Half life
Approximately 4 hours in adults with normal renal function.
Absorption
Rapidly and well absorbed from the gastrointestinal (GI) tract after oral administration. Peak plasma concentrations are typically reached within 1-2 hours.
Metabolism
Partially metabolized in the liver via the cytochrome P450 system, forming several metabolites, some of which have antimicrobial activity.
Side Effects
Contraindications
- Hypersensitivity to Enar or other fluoroquinolones.
- Concomitant administration with tizanidine.
- History of tendinitis or tendon rupture associated with quinolone use.
Drug Interactions
Warfarin
May enhance the anticoagulant effect of warfarin. Monitor INR regularly.
Tizanidine
Concomitant use is contraindicated due to a significant increase in tizanidine plasma concentrations, leading to hypotension and sedation.
Theophylline
May increase theophylline levels, leading to toxicity. Monitor theophylline levels.
NSAIDs (Nonsteroidal Anti-inflammatory Drugs)
May increase the risk of CNS stimulation and convulsions when used concurrently with Enar.
Antacids (Magnesium/Aluminum), Sucralfate, Didanosine
Can significantly reduce Enar absorption. Administer Enar at least 2 hours before or 6 hours after these agents.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
In case of an overdose, symptomatic and supportive treatment should be initiated. Gastric lavage and activated charcoal may be used shortly after ingestion. Hemodialysis or peritoneal dialysis is not effective in removing Enar from the body.
Pregnancy & Lactation
Enar should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. It is excreted in breast milk and is not recommended during breastfeeding due to potential risk of serious adverse reactions in the infant.
Side Effects
Contraindications
- Hypersensitivity to Enar or other fluoroquinolones.
- Concomitant administration with tizanidine.
- History of tendinitis or tendon rupture associated with quinolone use.
Drug Interactions
Warfarin
May enhance the anticoagulant effect of warfarin. Monitor INR regularly.
Tizanidine
Concomitant use is contraindicated due to a significant increase in tizanidine plasma concentrations, leading to hypotension and sedation.
Theophylline
May increase theophylline levels, leading to toxicity. Monitor theophylline levels.
NSAIDs (Nonsteroidal Anti-inflammatory Drugs)
May increase the risk of CNS stimulation and convulsions when used concurrently with Enar.
Antacids (Magnesium/Aluminum), Sucralfate, Didanosine
Can significantly reduce Enar absorption. Administer Enar at least 2 hours before or 6 hours after these agents.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
In case of an overdose, symptomatic and supportive treatment should be initiated. Gastric lavage and activated charcoal may be used shortly after ingestion. Hemodialysis or peritoneal dialysis is not effective in removing Enar from the body.
Pregnancy & Lactation
Enar should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. It is excreted in breast milk and is not recommended during breastfeeding due to potential risk of serious adverse reactions in the infant.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months from the date of manufacture when stored under recommended conditions.
Availability
Pharmacies, Hospitals
Approval Status
Approved (DGDA, FDA)
Patent Status
Generic available
WHO Essential Medicine
YesClinical Trials
Enar (as a fluoroquinolone antibiotic) has undergone extensive clinical trials demonstrating its efficacy and safety for various bacterial infections. Post-marketing surveillance continues to monitor for rare adverse events.
Lab Monitoring
- Renal function tests (for prolonged therapy or in patients with impaired renal function)
- Liver function tests (periodically during long-term therapy)
- Complete blood count (CBC)
- ECG (in patients with risk factors for QT prolongation)
Doctor Notes
- Emphasize patient education regarding the importance of completing the full course and potential severe adverse effects like tendinopathy and CNS effects.
- Carefully assess drug interactions, especially with Tizanidine (contraindicated), Theophylline, Warfarin, and antacids.
- Consider renal function for dose adjustments, particularly in elderly patients.
Patient Guidelines
- Complete the full course of treatment as prescribed, even if your symptoms improve sooner.
- Drink plenty of fluids to stay hydrated and help prevent crystalluria.
- Avoid prolonged exposure to sunlight or artificial UV light as Enar can increase photosensitivity.
- Immediately report any pain, swelling, or inflammation of a tendon to your doctor.
- Do not take Enar with dairy products, calcium-fortified juices, or antacids. Maintain a 2-6 hour gap.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Enar may cause dizziness, lightheadedness, or visual disturbances, which could impair your ability to drive or operate machinery. Exercise caution and avoid such activities if you experience these effects.
Lifestyle Advice
- Maintain a healthy diet and lifestyle during treatment.
- Avoid strenuous physical activity during treatment to minimize the risk of tendon damage.
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