Enoparin
Generic Name
Enoxaparin Sodium
Manufacturer
Leading Pharmaceutical Co.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| enoparin 4000 anti xa injection | ৳ 460.00 | N/A |
Description
Overview of the medicine
Enoparin 4000 anti-Xa injection contains Enoxaparin Sodium, a low molecular weight heparin (LMWH), used to prevent and treat various thromboembolic disorders such as deep vein thrombosis (DVT) and pulmonary embolism (PE). It works by inhibiting specific clotting factors in the blood.
Uses & Indications
Dosage
Adults
For DVT prophylaxis: 40 mg (4000 anti-Xa IU) once daily SC. For DVT/PE treatment: 1 mg/kg (100 anti-Xa IU/kg) every 12 hours SC, or 1.5 mg/kg (150 anti-Xa IU/kg) once daily SC.
Elderly
No dose adjustment usually required for age, but monitor renal function carefully.
Renal_impairment
Severe renal impairment (CrCl < 30 mL/min) requires dose adjustment (e.g., 20 mg once daily for prophylaxis, 1 mg/kg once daily for treatment).
How to Take
Administer by deep subcutaneous injection into the anterolateral or posterolateral abdominal wall, alternating between the left and right sides. Do not inject into the muscle. Do not expel the air bubble from the syringe before injection.
Mechanism of Action
Enoxaparin selectively potentiates the inhibitory effect of antithrombin III on Factor Xa, and to a lesser extent, on Factor IIa (thrombin). This results in anticoagulant activity by preventing clot formation.
Pharmacokinetics
Onset
Within 3-5 hours after SC injection.
Excretion
Renal elimination (around 40% as active or partially active fragments).
Half life
Approximately 4.5 to 7 hours after a single SC dose.
Absorption
Rapid and complete after subcutaneous (SC) injection. Bioavailability is approximately 100%.
Metabolism
Primarily desulfation and depolymerization in the liver to lower molecular weight species with reduced biological potency.
Side Effects
Contraindications
- Active major bleeding.
- History of heparin-induced thrombocytopenia (HIT) with or without thrombosis.
- Hypersensitivity to enoxaparin, heparin, or pork products.
- Acute bacterial endocarditis.
- Severe uncontrolled hypertension.
Drug Interactions
Warfarin
Increased risk of bleeding (careful monitoring required when transitioning).
NSAIDs (e.g., Aspirin, Ibuprofen)
Increased risk of bleeding.
Platelet inhibitors (e.g., Clopidogrel)
Increased risk of bleeding.
Other anticoagulants (e.g., Heparin, Dabigatran)
Increased risk of bleeding.
Storage
Store at room temperature (20°C to 25°C), away from light and moisture. Do not freeze.
Overdose
Accidental overdose may lead to hemorrhagic complications. The anticoagulant effects can be largely neutralized by the slow intravenous injection of protamine sulfate.
Pregnancy & Lactation
Pregnancy Category B. Generally considered safe for use during pregnancy when indicated. Use with caution during lactation; small amounts may be excreted in breast milk. Consult a doctor.
Side Effects
Contraindications
- Active major bleeding.
- History of heparin-induced thrombocytopenia (HIT) with or without thrombosis.
- Hypersensitivity to enoxaparin, heparin, or pork products.
- Acute bacterial endocarditis.
- Severe uncontrolled hypertension.
Drug Interactions
Warfarin
Increased risk of bleeding (careful monitoring required when transitioning).
NSAIDs (e.g., Aspirin, Ibuprofen)
Increased risk of bleeding.
Platelet inhibitors (e.g., Clopidogrel)
Increased risk of bleeding.
Other anticoagulants (e.g., Heparin, Dabigatran)
Increased risk of bleeding.
Storage
Store at room temperature (20°C to 25°C), away from light and moisture. Do not freeze.
Overdose
Accidental overdose may lead to hemorrhagic complications. The anticoagulant effects can be largely neutralized by the slow intravenous injection of protamine sulfate.
Pregnancy & Lactation
Pregnancy Category B. Generally considered safe for use during pregnancy when indicated. Use with caution during lactation; small amounts may be excreted in breast milk. Consult a doctor.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
2-3 years, check product specific label for exact duration.
Availability
Hospitals, pharmacies
Approval Status
Approved
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Numerous clinical trials have established the efficacy and safety of enoxaparin in DVT/PE prophylaxis and treatment, as well as in acute coronary syndromes.
Lab Monitoring
- Complete Blood Count (CBC) with platelet count.
- Renal function (creatinine clearance).
- Anti-Xa levels (not routinely required, but may be useful in specific populations like renal impairment, obesity, or pregnancy).
- Stool occult blood testing.
Doctor Notes
- Emphasize proper subcutaneous injection technique to minimize bruising.
- Monitor patients for signs of bleeding, especially if co-administered with other antiplatelet or anticoagulant agents.
- Renal function assessment is crucial, particularly in elderly patients and those with pre-existing renal impairment.
Patient Guidelines
- Do not rub the injection site after administration.
- Report any unusual bleeding or bruising to your doctor immediately.
- Inform your doctor or dentist about enoxaparin use before any surgical or dental procedures.
Missed Dose Advice
If a dose is missed, administer it as soon as possible. If it is almost time for the next dose, skip the missed dose and resume the regular dosing schedule. Do not double the dose.
Driving Precautions
Enoxaparin is unlikely to affect the ability to drive or operate machinery.
Lifestyle Advice
- Avoid activities that may cause injury or bleeding.
- Be cautious when using sharp objects.
- Report any falls or trauma, even if minor.
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