Medicine Information

Enoparin

Name: Enoparin
Brand: Enoparin
Rating: 4.5 (117 reviews)

Solution for Injection (pre-filled syringe)60 mg/0.6 mL (6000 anti-Xa IU)AnticoagulantsATC: B01AB05

Generic Name

Enoxaparin Sodium

Manufacturer

Generic Pharmaceutical Company

Country

Multiple Countries

Loading images...

Price Details

Current market pricing information

Variant	Unit Price	Strip Price
enoparin 6000 anti xa injection	৳ 575.00	N/A

Description

Overview of the medicine

Enoparin-6000-anti-Xa-injection is a low molecular weight heparin (LMWH) containing enoxaparin sodium, used to prevent and treat various thromboembolic disorders. It works by inhibiting coagulation factors, primarily Factor Xa.

Uses & Indications

Prevention of deep vein thrombosis (DVT) and pulmonary embolism (PE) in surgical and medical patients.

Treatment of DVT and PE.

Prevention of ischemic complications in unstable angina and non-ST-segment elevation myocardial infarction (NSTEMI).

Prophylaxis of thrombus formation in extracorporeal circulation during hemodialysis.

Dosage

Adults

DVT prophylaxis: 40 mg SC once daily or 30 mg SC every 12 hours. DVT/PE treatment: 1 mg/kg SC every 12 hours or 1.5 mg/kg SC once daily.

Elderly

Dose reduction may be considered, especially in renal impairment. Monitor anti-Xa levels if indicated.

Renal_impairment

Severe renal impairment (CrCl <30 mL/min) requires dose adjustment (e.g., 30 mg SC once daily for prophylaxis, 1 mg/kg SC once daily for treatment).

How to Take

Administered via subcutaneous (SC) injection into the abdominal wall. Do not inject intramuscularly. Alternate injection sites.

Mechanism of Action

Enoxaparin binds to antithrombin III (ATIII), increasing its affinity for Factor Xa, and to a lesser extent, Factor IIa (thrombin). This binding inhibits these clotting factors, primarily Factor Xa, preventing the formation of fibrin clots.

Pharmacokinetics

Onset

3-5 hours (peak effect)

Excretion

Primarily renal elimination of active and inactive fragments.

Half life

Approximately 4.5 to 7 hours after a single SC dose.

Absorption

Rapid and complete after subcutaneous (SC) administration. Peak anti-Xa activity achieved in 3-5 hours.

Metabolism

Primarily desulfation and depolymerization in the liver to less active metabolites.

Side Effects

Contraindications

Active major bleeding or conditions with high risk of uncontrolled bleeding (e.g., hemorrhagic stroke, recent surgery with active bleeding).
History of heparin-induced thrombocytopenia (HIT) with or without thrombosis.
Hypersensitivity to enoxaparin, heparin, or porcine products.
Spinal/epidural anesthesia or lumbar puncture in patients receiving therapeutic anticoagulation with enoxaparin due to risk of spinal hematoma.

Drug Interactions

Dextran

Increased risk of bleeding.

NSAIDs, antiplatelet agents (e.g., aspirin, clopidogrel), other anticoagulants (e.g., warfarin, dabigatran)

Increased risk of bleeding.

Storage

Store below 25°C. Do not freeze. Protect from light. Keep out of reach of children.

Overdose

Accidental overdose may lead to hemorrhagic complications. The anticoagulant effects can be largely neutralized by the slow intravenous injection of protamine sulfate.

Pregnancy & Lactation

Pregnancy Category B. Generally considered safe for use during pregnancy when clinically indicated. Limited data on excretion in breast milk; generally considered compatible with breastfeeding with caution. Consult a doctor.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

1 pre-filled syringe2 pre-filled syringes5 pre-filled syringes10 pre-filled syringes

Shelf Life

2-3 years (check specific product label)

Availability

Hospitals, pharmacies

Approval Status

Approved by major regulatory bodies (e.g., FDA, EMA, DGDA)

Patent Status

Generics available, original patent expired

WHO Essential Medicine

Yes

Clinical Trials

Enoxaparin has been extensively studied in numerous clinical trials establishing its efficacy and safety for DVT/PE prophylaxis and treatment, and for managing acute coronary syndromes.

Lab Monitoring

Complete Blood Count (CBC) including platelet count (before and during therapy).
Renal function tests (e.g., creatinine clearance).
Anti-Xa levels (may be monitored in specific populations like renal impairment, obesity, pregnancy).
Stool occult blood tests.

Doctor Notes

Always assess bleeding risk factors before initiating enoxaparin.
Consider anti-Xa level monitoring in patients with severe renal impairment, extreme body weight, or during pregnancy.
Educate patients on proper injection technique and signs of bleeding.

Patient Guidelines

Inject exactly as directed by your doctor.
Do not rub the injection site after administration.
Report any unusual bleeding or bruising immediately.
Inform your doctor or dentist you are taking enoxaparin before any surgery or dental procedure.

Missed Dose Advice

If a dose is missed, administer it as soon as possible. If it is almost time for the next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.