Shake the suspension well before each use. Administer orally, preferably on an empty stomach for better absorption, or with food if gastrointestinal upset occurs. Use a calibrated measuring spoon or cup to ensure accurate dosing.

Erythromycin inhibits bacterial protein synthesis by reversibly binding to the 50S ribosomal subunit of susceptible microorganisms, thereby blocking the translocation reaction.

• •Hypersensitivity to erythromycin or any other macrolide antibiotic.
• •Co-administration with terfenadine, astemizole, cisapride, pimozide, or colchicine (risk of serious cardiac arrhythmias or other severe adverse effects).

Store dry powder below 30°C, protected from light and moisture. Keep out of reach of children. After reconstitution, store in a refrigerator (2-8°C) and do not freeze.

Symptoms of overdose may include nausea, vomiting, abdominal cramps, and diarrhea. Hepatic dysfunction and hearing loss may occur with very high doses. Management involves symptomatic and supportive care, including gastric lavage or induced emesis if ingestion is recent. Hemodialysis is not effective.

Pregnancy Category B. Erythromycin is generally considered safe for use during pregnancy, but should be used only if clearly needed. It is excreted in breast milk; caution should be exercised when administered to a nursing mother. Monitor for potential effects on the infant (e.g., gastrointestinal symptoms).