Esoprol MUPS
Generic Name
Esomeprazole (as Multiple Unit Pellet System)
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| esoprol mups 20 mg tablet | ৳ 10.00 | ৳ 100.00 |
| esoprol mups 40 mg tablet | ৳ 14.00 | ৳ 112.00 |
Description
Overview of the medicine
Esoprol MUPS is an anti-ulcerant drug containing Esomeprazole, a proton pump inhibitor, used to reduce stomach acid production and treat acid-related conditions like GERD, peptic ulcers, and Zollinger-Ellison syndrome. The MUPS formulation allows for improved absorption and therapeutic effects.
Uses & Indications
Dosage
Adults
GERD: 20-40 mg once daily for 4-8 weeks. Erosive Esophagitis: 20-40 mg once daily for 4-8 weeks. H. pylori eradication: 40 mg once daily with antibiotics for 10 days.
Elderly
No dosage adjustment generally required, but caution is advised in very frail patients.
Renal_impairment
No dosage adjustment generally required.
How to Take
Take orally, at least one hour before a meal. Capsules should be swallowed whole. If swallowing is difficult, the capsule can be opened and the pellets mixed with a small amount of water or fruit juice and swallowed immediately. Do not chew or crush the pellets.
Mechanism of Action
Esomeprazole inhibits the H+/K+-ATPase enzyme system (proton pump) in the gastric parietal cells, thereby blocking the final step of acid secretion.
Pharmacokinetics
Onset
Within 1 hour
Excretion
Primarily via urine (about 80%) and feces (about 20%) as metabolites.
Half life
Approximately 1-1.5 hours
Absorption
Rapidly absorbed after oral administration; bioavailability is about 64% after a single 40 mg dose.
Metabolism
Extensively metabolized in the liver by the cytochrome P450 enzyme system, primarily CYP2C19 and CYP3A4.
Side Effects
Contraindications
- Hypersensitivity to Esomeprazole, substituted benzimidazoles, or any component of the formulation.
- Concomitant use with Nelfinavir.
Drug Interactions
Digoxin
Increased absorption of digoxin.
Warfarin
Increased INR and prothrombin time.
Clopidogrel
Reduced antiplatelet effect of clopidogrel.
Methotrexate
Increased levels and prolonged exposure to methotrexate.
Atazanavir, Nelfinavir
Decreased plasma levels of antiretrovirals.
Storage
Store in a cool, dry place, away from light and moisture. Keep out of reach of children.
Overdose
Limited experience. Symptoms include drowsiness, tachycardia, headache, blurred vision, abdominal pain, diarrhea. Treatment is symptomatic and supportive.
Pregnancy & Lactation
Pregnancy Category C. Use only if clearly needed and potential benefits outweigh risks. Caution advised during lactation as Esomeprazole is likely excreted in human milk.
Side Effects
Contraindications
- Hypersensitivity to Esomeprazole, substituted benzimidazoles, or any component of the formulation.
- Concomitant use with Nelfinavir.
Drug Interactions
Digoxin
Increased absorption of digoxin.
Warfarin
Increased INR and prothrombin time.
Clopidogrel
Reduced antiplatelet effect of clopidogrel.
Methotrexate
Increased levels and prolonged exposure to methotrexate.
Atazanavir, Nelfinavir
Decreased plasma levels of antiretrovirals.
Storage
Store in a cool, dry place, away from light and moisture. Keep out of reach of children.
Overdose
Limited experience. Symptoms include drowsiness, tachycardia, headache, blurred vision, abdominal pain, diarrhea. Treatment is symptomatic and supportive.
Pregnancy & Lactation
Pregnancy Category C. Use only if clearly needed and potential benefits outweigh risks. Caution advised during lactation as Esomeprazole is likely excreted in human milk.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24-36 months
Availability
Pharmacies, Hospitals
Approval Status
Approved by regulatory bodies (e.g., FDA, DGDA)
Patent Status
Patent expired (generic versions available)
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials demonstrate efficacy in healing erosive esophagitis, reducing GERD symptoms, and H. pylori eradication.
Lab Monitoring
- Magnesium levels in patients on long-term therapy, especially with diuretics.
Doctor Notes
- Advise patients to complete the full course of treatment.
- Monitor for long-term side effects, especially bone density and magnesium levels.
Patient Guidelines
- Take as directed by your doctor.
- Do not chew or crush the capsule or pellets.
- Inform your doctor if symptoms do not improve or worsen.
Missed Dose Advice
If a dose is missed, take it as soon as you remember, unless it is almost time for the next dose. Do not take a double dose to make up for a missed one.
Driving Precautions
May cause dizziness or visual disturbances; use caution when driving or operating machinery.
Lifestyle Advice
- Avoid spicy or fatty foods.
- Elevate the head of your bed.
- Avoid eating large meals before bedtime.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.