Esoral
Generic Name
Esomeprazole
Manufacturer
Incepta Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| esoral 20 mg tablet | ৳ 6.00 | ৳ 84.00 |
Description
Overview of the medicine
Esomeprazole is a proton pump inhibitor that reduces the amount of acid produced in the stomach. It is used to treat acid-related disorders of the stomach and esophagus.
Uses & Indications
Dosage
Adults
Usually 20-40 mg once daily, 30-60 minutes before food. Duration depends on condition.
Elderly
No specific dose adjustment is usually needed.
Renal_impairment
No dose adjustment required for mild to moderate renal impairment. For severe impairment, caution is advised.
How to Take
Swallow the tablet whole with water. Do not chew, crush, or break it. Take at least 30-60 minutes before a meal.
Mechanism of Action
Esomeprazole inhibits the gastric H+/K+-ATPase (proton pump) in the parietal cells of the stomach, thereby blocking the final step of acid secretion.
Pharmacokinetics
Onset
Within 1 hour.
Excretion
Primarily excreted via the urine (approx. 80%) and feces (approx. 20%).
Half life
Approximately 1-1.5 hours.
Absorption
Rapidly absorbed after oral administration. Bioavailability increases with repeated dosing.
Metabolism
Extensively metabolized in the liver via cytochrome P450 enzymes (CYP2C19 and CYP3A4).
Side Effects
Contraindications
- Hypersensitivity to esomeprazole or any other benzimidazole substituted proton pump inhibitors.
- Patients with severe liver impairment may require dose adjustment.
Drug Interactions
Digoxin
May increase digoxin levels; monitor digoxin concentrations.
Warfarin
May increase INR and prothrombin time; monitor closely.
Clopidogrel
May reduce the antiplatelet effect of clopidogrel. Co-administration should be avoided.
Methotrexate
May increase serum methotrexate levels; monitor for toxicity.
Atazanavir, Nelfinavir
May significantly decrease absorption and reduce efficacy of antiretrovirals.
Storage
Store in a cool and dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
In case of overdose, symptomatic and supportive treatment should be administered. There is no specific antidote.
Pregnancy & Lactation
Use during pregnancy only if clearly needed and the potential benefits outweigh the risks. Limited data available on use during lactation; consult a doctor.
Side Effects
Contraindications
- Hypersensitivity to esomeprazole or any other benzimidazole substituted proton pump inhibitors.
- Patients with severe liver impairment may require dose adjustment.
Drug Interactions
Digoxin
May increase digoxin levels; monitor digoxin concentrations.
Warfarin
May increase INR and prothrombin time; monitor closely.
Clopidogrel
May reduce the antiplatelet effect of clopidogrel. Co-administration should be avoided.
Methotrexate
May increase serum methotrexate levels; monitor for toxicity.
Atazanavir, Nelfinavir
May significantly decrease absorption and reduce efficacy of antiretrovirals.
Storage
Store in a cool and dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
In case of overdose, symptomatic and supportive treatment should be administered. There is no specific antidote.
Pregnancy & Lactation
Use during pregnancy only if clearly needed and the potential benefits outweigh the risks. Limited data available on use during lactation; consult a doctor.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24-36 months from the date of manufacture.
Availability
Available in pharmacies and hospitals
Approval Status
Approved by DGDA and major regulatory bodies globally
Patent Status
Generic available
WHO Essential Medicine
YesClinical Trials
Esomeprazole has undergone extensive clinical trials demonstrating its efficacy and safety in the treatment of various acid-related disorders. Studies have shown superior acid control compared to some other PPIs.
Lab Monitoring
- No routine lab monitoring is required for short-term use. For long-term use (over 3 months), magnesium levels may need to be monitored. Bone mineral density might be considered for very prolonged use.
Doctor Notes
- Before initiating therapy, exclude the presence of gastric malignancy, as esomeprazole may mask symptoms.
- Caution when co-administering with clopidogrel due to potential reduction in antiplatelet effect.
- Advise patients on lifestyle modifications to complement drug therapy.
Patient Guidelines
- Take the medicine exactly as prescribed by your doctor.
- Do not stop taking the medicine suddenly without consulting your doctor.
- Inform your doctor about all other medications and supplements you are taking.
- Report any severe or persistent side effects to your doctor immediately.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
Esomeprazole may cause dizziness or visual disturbances in some individuals. If you experience these symptoms, avoid driving or operating machinery.
Lifestyle Advice
- Avoid trigger foods and beverages that worsen your acid reflux (e.g., spicy foods, fatty foods, caffeine, alcohol).
- Eat smaller, more frequent meals.
- Avoid lying down immediately after eating. Wait at least 2-3 hours.
- Elevate the head of your bed while sleeping to reduce nighttime reflux.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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