Esoral
Generic Name
Esomeprazole 40 mg tablet
Manufacturer
ACI Limited
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| esoral 40 mg tablet | ৳ 8.00 | ৳ 112.00 |
Description
Overview of the medicine
Esoral 40 mg Tablet contains Esomeprazole, a proton pump inhibitor, used to reduce stomach acid production and treat conditions like GERD, ulcers, and Zollinger-Ellison syndrome.
Uses & Indications
Dosage
Adults
Typically 20 mg or 40 mg once daily, depending on the condition. For severe GERD/Erosive Esophagitis: 40 mg once daily for 4-8 weeks. For H. pylori eradication: 40 mg once daily for 10 days with appropriate antibiotics. For Zollinger-Ellison Syndrome: Initial 40 mg twice daily, adjusted as needed.
Elderly
No dose adjustment generally required, but caution in patients with hepatic impairment.
Renal_impairment
No dose adjustment required for renal impairment.
How to Take
Take whole tablet at least one hour before a meal, preferably in the morning. Do not chew or crush.
Mechanism of Action
Esomeprazole is a proton pump inhibitor that specifically inhibits the H+/K+-ATPase enzyme system (the 'proton pump') in the gastric parietal cells. This inhibition blocks the final step in acid production, reducing both basal and stimulated gastric acid secretion.
Pharmacokinetics
Onset
Within 1 hour
Excretion
Primarily excreted in urine (approximately 80%) and feces (approximately 20%) as metabolites.
Half life
Approximately 1-1.5 hours
Absorption
Rapidly absorbed after oral administration, bioavailability increases with repeated dosing.
Metabolism
Extensively metabolized in the liver via CYP2C19 and CYP3A4 enzymes.
Side Effects
Contraindications
- Hypersensitivity to Esomeprazole or any proton pump inhibitor
- Co-administration with Nelfinavir
Drug Interactions
Digoxin
Increased absorption of digoxin.
Warfarin
Increased INR/prothrombin time; monitor closely.
Tacrolimus
Increased serum tacrolimus levels.
Clopidogrel
Reduced antiplatelet effect of clopidogrel (potential interaction, consult physician).
Methotrexate
Increased plasma levels of methotrexate (especially high dose).
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose are generally mild and include confusion, drowsiness, blurred vision, tachycardia, nausea, sweating, flushing, headache, dry mouth. Treatment is symptomatic and supportive.
Pregnancy & Lactation
Pregnancy Category B. Use during pregnancy only if clearly needed. Excreted in breast milk; advise caution/discontinue drug or nursing.
Side Effects
Contraindications
- Hypersensitivity to Esomeprazole or any proton pump inhibitor
- Co-administration with Nelfinavir
Drug Interactions
Digoxin
Increased absorption of digoxin.
Warfarin
Increased INR/prothrombin time; monitor closely.
Tacrolimus
Increased serum tacrolimus levels.
Clopidogrel
Reduced antiplatelet effect of clopidogrel (potential interaction, consult physician).
Methotrexate
Increased plasma levels of methotrexate (especially high dose).
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose are generally mild and include confusion, drowsiness, blurred vision, tachycardia, nausea, sweating, flushing, headache, dry mouth. Treatment is symptomatic and supportive.
Pregnancy & Lactation
Pregnancy Category B. Use during pregnancy only if clearly needed. Excreted in breast milk; advise caution/discontinue drug or nursing.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months from manufacturing date
Availability
Pharmacies, hospitals, clinics
Approval Status
FDA approved, DGDA approved
Patent Status
Patent expired for generic Esomeprazole
WHO Essential Medicine
YesClinical Trials
Extensively studied in numerous clinical trials demonstrating efficacy and safety for acid-related disorders.
Lab Monitoring
- Magnesium levels (with prolonged use)
- Liver function tests (in patients with hepatic impairment)
Doctor Notes
- Proton pump inhibitors like Esomeprazole should be prescribed for the shortest duration consistent with treatment goals.
- Evaluate patients for H. pylori infection before long-term PPI therapy.
- Consider magnesium supplementation in patients on long-term PPIs, especially with diuretics.
Patient Guidelines
- Take as directed by your doctor.
- Do not stop taking abruptly without consulting your doctor.
- Inform your doctor about all other medications you are taking.
- Report any severe or persistent side effects.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it's almost time for the next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
May cause dizziness or visual disturbances; use caution when driving or operating machinery until you know how the medicine affects you.
Lifestyle Advice
- Avoid large meals, especially before bedtime.
- Limit fatty foods, caffeine, and alcohol.
- Elevate the head of your bed if you suffer from GERD.
- Maintain a healthy weight.
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Global Brand Names
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