Etoricoxib
Generic Name
Etoricoxib 90 mg tablet
Manufacturer
Various manufacturers globally (e.g., Merck, Square Pharmaceuticals)
Country
Global
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| etoricoxib 90 mg tablet | ৳ 12.00 | ৳ 120.00 |
Description
Overview of the medicine
Etoricoxib is a selective cyclooxygenase-2 (COX-2) inhibitor belonging to the NSAID class, used to relieve pain and inflammation in conditions like osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, and acute gout.
Uses & Indications
Dosage
Adults
Osteoarthritis: 30 mg or 60 mg once daily. Rheumatoid Arthritis, Ankylosing Spondylitis: 60 mg or 90 mg once daily. Acute Gouty Arthritis: 120 mg once daily (for a maximum of 8 days). Acute Pain/Dental Surgery: 90 mg once daily (for a maximum of 3 days). Primary Dysmenorrhea: 120 mg once daily (for a maximum of 3 days). Maximum dose is 120 mg/day.
Elderly
No dose adjustment is generally necessary; however, caution should be exercised in elderly patients due to increased risk of adverse effects.
Renal_impairment
Mild renal impairment (CrCl 30-80 mL/min): No dose adjustment needed. Moderate to severe renal impairment (CrCl <30 mL/min): Not recommended.
How to Take
For oral administration. Can be taken with or without food. To minimize potential gastrointestinal upset, it is often recommended to take with food. Swallow the tablet whole with a glass of water.
Mechanism of Action
Etoricoxib selectively inhibits cyclooxygenase-2 (COX-2), an enzyme responsible for the synthesis of prostaglandins, which are mediators of pain, inflammation, and fever. By inhibiting COX-2, etoricoxib reduces prostaglandin production, thereby alleviating pain and inflammation.
Pharmacokinetics
Onset
Pain relief typically begins within 24 minutes for acute conditions, and within 24 hours for chronic conditions.
Excretion
Eliminated primarily by the kidneys (approximately 70% as metabolites) and via feces (approximately 20% as metabolites).
Half life
Approximately 22 hours.
Absorption
Rapidly absorbed after oral administration, with peak plasma concentrations achieved in approximately 1 hour.
Metabolism
Extensively metabolized by cytochrome P450 enzymes (primarily CYP3A4) to inactive metabolites.
Side Effects
Contraindications
- •Hypersensitivity to etoricoxib or any component of the formulation
- •Active peptic ulceration or gastrointestinal bleeding
- •Severe hepatic dysfunction
- •Severe renal impairment (creatinine clearance <30 mL/min)
- •Inflammatory bowel disease
- •Congestive heart failure (NYHA Class II-IV)
- •Established ischemic heart disease, peripheral arterial disease, and/or cerebrovascular disease
- •Pregnancy and lactation
Drug Interactions
Lithium
May increase plasma lithium levels, leading to toxicity.
Warfarin
May increase the risk of bleeding. Close INR monitoring is required.
Diuretics
May reduce natriuretic effect and increase risk of renal impairment.
Methotrexate
May increase methotrexate toxicity due to reduced renal clearance.
ACE Inhibitors/ARBs
May reduce the antihypertensive effect and increase the risk of renal impairment.
Oral Contraceptives
May increase plasma concentrations of ethinylestradiol, potentially increasing adverse effects.
Storage
Store below 30°C in a dry place, away from direct light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose are generally mild and may include gastrointestinal disturbances (e.g., nausea, vomiting, abdominal pain) and renal impairment. Management is supportive and symptomatic; there is no specific antidote. Gastric decontamination (e.g., activated charcoal) may be considered if ingestion is recent.
Pregnancy & Lactation
Contraindicated during pregnancy, especially in the third trimester due to potential premature closure of the fetal ductus arteriosus. Not recommended during lactation as etoricoxib is excreted in breast milk.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from the date of manufacture when stored correctly.
Availability
Pharmacies, Hospitals
Approval Status
Approved by regulatory authorities in many countries (e.g., EMA, DGDA in Bangladesh)
Patent Status
Patents have expired in most markets, allowing generic versions
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Global Brand Names
International brand names for this medicine
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