Evadol
Generic Name
Paracetamol
Manufacturer
Renata Limited
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| evadol 2 mg tablet | ৳ 18.00 | ৳ 180.00 |
Description
Overview of the medicine
Evadol is used to relieve mild to moderate pain and reduce fever. It is a widely used over-the-counter medicine.
Uses & Indications
Dosage
Adults
500 mg to 1000 mg (1-2 tablets) every 4-6 hours as needed, not exceeding 4000 mg (8 tablets) in 24 hours.
Elderly
Same as adult dose, but caution should be exercised in patients with impaired renal or hepatic function.
Renal_impairment
Dose adjustment may be necessary. For creatinine clearance 10-50 ml/min, dose every 6 hours; <10 ml/min, dose every 8 hours.
How to Take
Oral administration with or without food. Suppositories are administered rectally.
Mechanism of Action
Paracetamol works by inhibiting prostaglandin synthesis, primarily in the central nervous system, which helps to reduce pain and fever.
Pharmacokinetics
Onset
30-60 minutes
Excretion
Excreted mainly by the kidneys as glucuronide and sulfate conjugates; less than 5% is excreted unchanged.
Half life
1-4 hours (average 2-3 hours)
Absorption
Rapidly and almost completely absorbed from the gastrointestinal tract; peak plasma concentrations occur within 30-60 minutes.
Metabolism
Primarily metabolized in the liver via glucuronidation and sulfation. A small amount is metabolized by cytochrome P450 to a highly reactive intermediate, NAPQI, which is then detoxified by glutathione.
Side Effects
Contraindications
- Hypersensitivity to paracetamol or any component of the formulation
- Severe hepatic impairment or active liver disease
Drug Interactions
0
Warfarin and other coumarins: May enhance anticoagulant effect, increasing risk of bleeding.
1
Alcohol: Increased risk of hepatotoxicity with chronic heavy alcohol consumption.
2
Other paracetamol-containing products: Increased risk of overdose and liver damage.
3
Phenobarbital, phenytoin, carbamazepine: May increase the metabolism of paracetamol, reducing its effectiveness and increasing risk of hepatotoxicity.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Overdose can lead to severe liver damage (hepatic necrosis), which can be fatal. Symptoms may include nausea, vomiting, abdominal pain, and loss of appetite. N-acetylcysteine is the antidote and should be administered as soon as possible.
Pregnancy & Lactation
Generally considered safe during pregnancy and lactation at recommended doses, but consult a doctor before use.
Side Effects
Contraindications
- Hypersensitivity to paracetamol or any component of the formulation
- Severe hepatic impairment or active liver disease
Drug Interactions
0
Warfarin and other coumarins: May enhance anticoagulant effect, increasing risk of bleeding.
1
Alcohol: Increased risk of hepatotoxicity with chronic heavy alcohol consumption.
2
Other paracetamol-containing products: Increased risk of overdose and liver damage.
3
Phenobarbital, phenytoin, carbamazepine: May increase the metabolism of paracetamol, reducing its effectiveness and increasing risk of hepatotoxicity.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Overdose can lead to severe liver damage (hepatic necrosis), which can be fatal. Symptoms may include nausea, vomiting, abdominal pain, and loss of appetite. N-acetylcysteine is the antidote and should be administered as soon as possible.
Pregnancy & Lactation
Generally considered safe during pregnancy and lactation at recommended doses, but consult a doctor before use.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from the date of manufacture.
Availability
Pharmacies, supermarkets
Approval Status
Generally Approved
Patent Status
Expired
WHO Essential Medicine
YesClinical Trials
Paracetamol is a well-established drug with extensive clinical trial data supporting its efficacy and safety profile over decades of use.
Lab Monitoring
- Liver function tests (ALT, AST) if used long-term or in cases of suspected overdose.
- Renal function tests in patients with renal impairment.
Doctor Notes
- Emphasize strict adherence to dosing limits to prevent hepatotoxicity.
- Advise patients to check other OTC products for paracetamol content to avoid cumulative overdose.
- Exercise caution in patients with chronic alcoholism or pre-existing liver disease.
Patient Guidelines
- Do not exceed the recommended dose.
- Avoid taking with other medicines containing paracetamol.
- If symptoms persist for more than 3 days (for fever) or 5 days (for pain), consult a doctor.
- Do not use for children under 2 months without medical advice.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
Evadol is generally not known to affect the ability to drive or operate machinery.
Lifestyle Advice
- Stay hydrated, especially when having a fever.
- Get adequate rest to aid recovery from illness.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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