Eval
Generic Name
Cefixime
Manufacturer
Hypothetical Pharma Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| eval 250 mg tablet | ৳ 3.50 | ৳ 35.00 |
Description
Overview of the medicine
Eval 250 mg Tablet contains Cefixime, a third-generation cephalosporin antibiotic used to treat a wide range of bacterial infections. It works by stopping the growth of bacteria. It is effective against respiratory tract infections, urinary tract infections, otitis media, pharyngitis, tonsillitis, and uncomplicated gonorrhea.
Uses & Indications
Dosage
Adults
The usual adult dose is 400 mg daily, either as a single dose or in two divided doses (e.g., 200 mg every 12 hours). For severe infections, the dose may be increased. For uncomplicated gonorrhea, a single 400 mg dose is recommended.
Elderly
No specific dose adjustment is required solely based on age; however, renal function should be assessed and dose adjusted if renal impairment is present.
Renal_impairment
For creatinine clearance less than 60 mL/min, the dose should be reduced. For creatinine clearance 21-60 mL/min, 300 mg daily. For creatinine clearance less than 20 mL/min, 200 mg daily.
How to Take
Eval 250 mg Tablet should be taken orally with water. It can be taken with or without food. To achieve best results, complete the full course of treatment as prescribed by your doctor, even if symptoms improve.
Mechanism of Action
Cefixime is a bactericidal antibiotic that inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs). This leads to the disruption of the cell wall, resulting in bacterial cell lysis and death.
Pharmacokinetics
Onset
Peak plasma concentrations are achieved within 2-6 hours after administration.
Excretion
Excreted predominantly by the kidneys (approximately 50% as unchanged drug in urine) and partially via biliary/fecal route.
Half life
Plasma half-life is typically 3-4 hours.
Absorption
Approximately 40-50% orally absorbed. Food can delay absorption but does not significantly alter the extent of absorption.
Metabolism
Minimal hepatic metabolism; primarily excreted unchanged.
Side Effects
Contraindications
- Known hypersensitivity to Cefixime or other cephalosporin antibiotics.
- History of severe hypersensitivity reactions to penicillin or other beta-lactam antibiotics.
Drug Interactions
Nifedipine
May increase peak plasma levels and AUC of Cefixime.
Carbamazepine
Elevated carbamazepine levels have been reported when co-administered with Cefixime.
Anticoagulants (e.g., Warfarin)
May increase prothrombin time (PT) with or without bleeding, monitor INR closely.
Storage
Store below 30°C in a dry place, away from direct sunlight and moisture. Keep out of reach of children.
Overdose
In case of overdose, gastric lavage may be indicated. Cefixime is not removed in significant quantities from the circulation by hemodialysis or peritoneal dialysis. Treatment should be symptomatic and supportive.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have not shown harm to the fetus, but there are no adequate and well-controlled studies in pregnant women. Use during pregnancy only if clearly needed. Cefixime is excreted in small amounts in breast milk; use with caution in nursing mothers.
Side Effects
Contraindications
- Known hypersensitivity to Cefixime or other cephalosporin antibiotics.
- History of severe hypersensitivity reactions to penicillin or other beta-lactam antibiotics.
Drug Interactions
Nifedipine
May increase peak plasma levels and AUC of Cefixime.
Carbamazepine
Elevated carbamazepine levels have been reported when co-administered with Cefixime.
Anticoagulants (e.g., Warfarin)
May increase prothrombin time (PT) with or without bleeding, monitor INR closely.
Storage
Store below 30°C in a dry place, away from direct sunlight and moisture. Keep out of reach of children.
Overdose
In case of overdose, gastric lavage may be indicated. Cefixime is not removed in significant quantities from the circulation by hemodialysis or peritoneal dialysis. Treatment should be symptomatic and supportive.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have not shown harm to the fetus, but there are no adequate and well-controlled studies in pregnant women. Use during pregnancy only if clearly needed. Cefixime is excreted in small amounts in breast milk; use with caution in nursing mothers.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
2-3 years from the date of manufacture, depending on storage conditions.
Availability
Pharmacies nationwide
Approval Status
Approved
Patent Status
Generic available
WHO Essential Medicine
YesClinical Trials
Cefixime has undergone extensive clinical trials demonstrating its efficacy and safety in various bacterial infections. Ongoing post-marketing surveillance continues to monitor its long-term effects.
Lab Monitoring
- Renal function tests (for prolonged therapy or in patients with pre-existing renal impairment)
- Complete Blood Count (CBC) (rarely, for prolonged therapy to check for hematological abnormalities)
- Liver function tests (LFTs) (rarely, in patients with pre-existing liver conditions)
Doctor Notes
- Consider culture and susceptibility testing before initiating therapy to identify the causative organism and its sensitivity to Cefixime.
- Educate patients on the importance of completing the full course of treatment to prevent resistance.
Patient Guidelines
- Take the medicine exactly as prescribed by your doctor.
- Complete the entire course of medication, even if you start to feel better.
- Do not share your medicine with others.
- Inform your doctor if you experience any severe side effects.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.
Driving Precautions
Cefixime generally does not impair the ability to drive or operate machinery. However, if you experience dizziness or other side effects that could affect your concentration, avoid these activities.
Lifestyle Advice
- Maintain good hygiene to prevent further infections.
- Drink plenty of fluids to stay hydrated, especially if experiencing diarrhea.
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Global Brand Names
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