Medicine Information

Eval

Name: Eval
Brand: Eval
Rating: 4.5 (117 reviews)

Syrup / Oral Suspension250 mg/5 mlAntibacterial (Penicillin-type)ATC: J01CA04

Generic Name

Amoxicillin

Manufacturer

Example Pharma Ltd.

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
eval 250 mg syrup	৳ 90.00	N/A

Description

Overview of the medicine

Eval 250 mg syrup contains Amoxicillin, a penicillin-type antibiotic used to treat a wide range of bacterial infections.

Uses & Indications

Respiratory tract infections

Urinary tract infections

Skin and soft tissue infections

Otitis media

Sinusitis

Helicobacter pylori eradication (as part of combination therapy)

Dosage

Adults

Typically 250-500 mg every 8 hours, or 500-875 mg every 12 hours. For Eval 250 mg syrup, adult doses would involve multiple spoonfuls.

Elderly

Similar to adults, but dosage adjustment may be needed based on renal function.

Renal_impairment

Dose reduction necessary in severe renal impairment (e.g., creatinine clearance <30 ml/min).

How to Take

For oral use. Can be taken with or without food. Shake the bottle well before each use. Use a measuring spoon or cup.

Mechanism of Action

Amoxicillin inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), leading to bacterial cell lysis and death.

Pharmacokinetics

Onset

Within 1-2 hours

Excretion

Mainly excreted unchanged by the kidneys via tubular secretion and glomerular filtration.

Half life

Approximately 1-1.5 hours in adults with normal renal function.

Absorption

Rapidly and well absorbed from the gastrointestinal tract, not significantly affected by food.

Metabolism

Limited hepatic metabolism; primarily forms inactive penicilloic acid.

Side Effects

Contraindications

Hypersensitivity to amoxicillin or other penicillins
History of severe hypersensitivity reaction to another beta-lactam agent (e.g., cephalosporin, carbapenem or monobactam)

Drug Interactions

Probenecid

Increases and prolongs amoxicillin blood levels by decreasing renal tubular secretion.

Methotrexate

Increases methotrexate toxicity due to reduced renal clearance.

Oral contraceptives

May reduce efficacy of oral contraceptives (rare).

Warfarin and other oral anticoagulants

May prolong prothrombin time; monitor INR closely.

Storage

Store dry powder at room temperature (below 30°C), protect from moisture. After reconstitution, store in a refrigerator (2-8°C) and discard unused portion after the specified period.

Overdose

Symptoms may include gastrointestinal effects (nausea, vomiting, diarrhea) and disturbances of fluid and electrolyte balance. Renal impairment or convulsions may occur. Treatment is supportive and symptomatic; hemodialysis may be used to remove amoxicillin.

Pregnancy & Lactation

Amoxicillin is generally considered safe during pregnancy (Category B). Small amounts are excreted in breast milk, generally considered safe but monitor infant for potential adverse effects (e.g., diarrhea, candidiasis).

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

60 ml bottle100 ml bottle

Shelf Life

24-36 months for dry powder; 7-14 days after reconstitution (refrigerated).

Availability

Pharmacies, hospitals, clinics

Approval Status

Approved by relevant health authorities globally

Patent Status

Generic available, original patent expired

WHO Essential Medicine

Yes

Clinical Trials

Amoxicillin has been extensively studied in numerous clinical trials establishing its efficacy and safety for bacterial infections.

Lab Monitoring

Renal function tests (for prolonged therapy or renal impairment)
Liver function tests (rarely, if hepatotoxicity suspected)
Complete blood count (for prolonged therapy)

Doctor Notes

Advise patients on the importance of completing the full course.
Monitor for signs of allergic reactions, especially within the first few doses.
Consider renal function in elderly or renally impaired patients.

Patient Guidelines

Complete the full course of medication even if symptoms improve.
Do not save medication for future use.
Report any severe allergic reactions immediately.
Shake well before use.

Missed Dose Advice

If a dose is missed, take it as soon as you remember, unless it's almost time for your next dose. Do not double the dose.

Driving Precautions

Generally not expected to affect ability to drive or operate machinery. However, if side effects like dizziness occur, avoid such activities.

Lifestyle Advice

Stay hydrated, especially if experiencing diarrhea.
Avoid alcohol during antibiotic treatment (general advice, though not a specific interaction with amoxicillin).