Evoxil-CV
Generic Name
Amoxicillin and Clavulanic Acid
Manufacturer
Example Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| evoxil cv 125 mg suspension | ৳ 220.00 | N/A |
Description
Overview of the medicine
Evoxil-CV 125 mg Suspension is an antibiotic medication combining Amoxicillin, a penicillin-type antibiotic, and Clavulanic Acid, a beta-lactamase inhibitor. It is used to treat a wide range of bacterial infections.
Uses & Indications
Dosage
Adults
This strength is primarily for pediatric use. Adults typically use higher strength tablets.
Elderly
Dosage should be adjusted based on renal function. Generally, follow adult recommendations with caution.
Renal_impairment
Dosage adjustment is necessary. For mild impairment (CrCl >30 mL/min), no adjustment needed. For moderate (CrCl 10-30 mL/min), 125 mg every 12 hours. For severe (CrCl <10 mL/min), 125 mg every 24 hours. Hemodialysis patients: 125 mg initially, then 125 mg at the end of dialysis.
How to Take
Administer orally. Shake the bottle well before each use. Can be taken with or without food. To minimize potential gastrointestinal intolerance, administer at the start of a meal.
Mechanism of Action
Amoxicillin inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), leading to cell lysis. Clavulanic acid irreversibly binds to and inactivates beta-lactamase enzymes produced by bacteria, which would otherwise degrade amoxicillin, thus extending amoxicillin's spectrum of activity.
Pharmacokinetics
Onset
Antibacterial activity usually begins within 30-60 minutes after administration.
Excretion
Both components are primarily excreted unchanged in the urine, with some hepatic metabolism for clavulanic acid.
Half life
Approximately 1-1.5 hours for both components.
Absorption
Both Amoxicillin and Clavulanic Acid are well absorbed from the gastrointestinal tract after oral administration, with peak plasma concentrations occurring approximately 1-2 hours after dosing. Food has minimal effect on absorption.
Metabolism
Amoxicillin is partially metabolized to an inactive penicilloic acid. Clavulanic acid is extensively metabolized.
Side Effects
Contraindications
- •History of severe hypersensitivity reaction to beta-lactam antibiotics (e.g., anaphylaxis to penicillin or cephalosporins)
- •History of amoxicillin-clavulanate-associated jaundice/hepatic dysfunction
- •Infectious mononucleosis (risk of rash)
Drug Interactions
Probenecid
Increases amoxicillin blood levels by decreasing renal tubular secretion.
Allopurinol
Increased incidence of rash, especially in hyperuricemic patients.
Methotrexate
May increase methotrexate toxicity; monitor levels.
Oral Contraceptives
May reduce efficacy of oral contraceptives (rarely).
Anticoagulants (e.g., Warfarin)
May prolong prothrombin time; monitor INR.
Storage
Store the dry powder below 25°C in a dry place, away from direct light and moisture. After reconstitution, store the suspension in a refrigerator (2-8°C) and discard after 7-14 days.
Overdose
Symptoms may include gastrointestinal symptoms (e.g., abdominal pain, vomiting, diarrhea) and disturbances of fluid and electrolyte balance. Renal impairment and convulsions may occur in severe cases. Treatment is symptomatic and supportive. Hemodialysis can remove both components from circulation.
Pregnancy & Lactation
Pregnancy Category B. Generally considered safe for use during pregnancy, but use only if clearly needed. Both amoxicillin and clavulanic acid are excreted into breast milk; use with caution during lactation and monitor infant for diarrhea, candidiasis, and skin rash.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Unreconstituted powder: 24-36 months. Reconstituted suspension: 7-14 days when stored in a refrigerator (check specific product instructions).
Availability
Pharmacies, hospitals
Approval Status
Approved by regulatory bodies (e.g., FDA, DGDA)
Patent Status
Generic available (original patent expired)
WHO Essential Medicine
YesAlternative Medicines in Bangladesh
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Global Brand Names
International brand names for this medicine
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