Medicine Information

Exilok

Name: Exilok
Brand: Exilok

Powder for solution for injection40 mgProton Pump Inhibitors (PPIs)ATC: A02BC05

Generic Name

Esomeprazole Sodium

Manufacturer

Incepta Pharmaceuticals Ltd.

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
exilok 40 mg injection	৳ 100.00	N/A

Description

Overview of the medicine

Exilok 40 mg Injection contains Esomeprazole, a proton pump inhibitor, used to reduce stomach acid production. It is prescribed for conditions like gastroesophageal reflux disease (GERD), ulcers, and other acid-related disorders, especially when oral therapy is not feasible.

Uses & Indications

Gastroesophageal Reflux Disease (GERD) with erosive esophagitis

Healing of gastric ulcers associated with NSAID therapy

Short-term treatment of Zollinger-Ellison syndrome

Prophylaxis of re-bleeding of gastric or duodenal ulcers following endoscopic therapy

Stress ulcer prophylaxis in critically ill patients

Dosage

Adults

Usually 40 mg once daily by IV infusion over 10-30 minutes for 7-10 days, or as directed by physician. For Zollinger-Ellison syndrome, initial dose is 80 mg twice daily.

Elderly

No dosage adjustment generally required, but caution in patients with severe hepatic impairment.

Renal_impairment

No dosage adjustment required for mild to moderate renal impairment; caution in severe impairment.

How to Take

Exilok 40 mg Injection is administered intravenously (IV) as an infusion over a period of 10-30 minutes. It should be reconstituted with sterile normal saline or 5% dextrose solution as per product instructions before use. Do not administer as a bolus injection.

Mechanism of Action

Esomeprazole is a proton pump inhibitor that irreversibly blocks the H+/K+-ATPase enzyme system (the proton pump) in the gastric parietal cells. This action effectively reduces both basal and stimulated gastric acid secretion, leading to prolonged acid suppression.

Pharmacokinetics

Onset

Within 30-60 minutes.

Excretion

Mainly excreted renally (approximately 80%), with a smaller portion in feces (approximately 20%).

Half life

Approximately 1-1.5 hours.

Absorption

Rapidly absorbed after intravenous administration, high systemic bioavailability.

Metabolism

Extensively metabolized in the liver by the cytochrome P450 system (primarily CYP2C19 and CYP3A4).

Side Effects

Contraindications

Hypersensitivity to esomeprazole, substituted benzimidazoles, or any component of the formulation.
Concomitant use with nelfinavir.

Drug Interactions

Warfarin

Increased INR and prothrombin time, monitor carefully.

Clopidogrel

Reduced antiplatelet effect of clopidogrel (clinical significance debated, but caution advised).

Methotrexate

Possible increased methotrexate levels, especially with high-dose methotrexate.

Nelfinavir, Atazanavir

Reduced plasma levels of antiretroviral drugs, leading to loss of therapeutic effect.

Storage

Store below 30°C, protected from light and moisture. Do not freeze. Reconstituted solution should be used immediately or within specified time according to product leaflet.

Overdose

Symptoms may include gastrointestinal disturbances and weakness. Treatment is symptomatic and supportive. Esomeprazole is extensively protein bound and not readily dialyzable.

Pregnancy & Lactation

Pregnancy Category C. Use only if potential benefit justifies potential risk to the fetus. Esomeprazole is excreted in human milk; caution should be exercised when administered to a nursing woman.

Side Effects

Contraindications

Hypersensitivity to esomeprazole, substituted benzimidazoles, or any component of the formulation.
Concomitant use with nelfinavir.

Drug Interactions

Warfarin

Increased INR and prothrombin time, monitor carefully.

Clopidogrel

Reduced antiplatelet effect of clopidogrel (clinical significance debated, but caution advised).

Methotrexate

Possible increased methotrexate levels, especially with high-dose methotrexate.

Nelfinavir, Atazanavir

Reduced plasma levels of antiretroviral drugs, leading to loss of therapeutic effect.

Storage

Store below 30°C, protected from light and moisture. Do not freeze. Reconstituted solution should be used immediately or within specified time according to product leaflet.

Overdose

Symptoms may include gastrointestinal disturbances and weakness. Treatment is symptomatic and supportive. Esomeprazole is extensively protein bound and not readily dialyzable.

Pregnancy & Lactation

Pregnancy Category C. Use only if potential benefit justifies potential risk to the fetus. Esomeprazole is excreted in human milk; caution should be exercised when administered to a nursing woman.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

1 vial per pack

Shelf Life

Typically 24-36 months when stored as per recommendations. Reconstituted solution has a shorter shelf life (e.g., 6 hours at room temperature for some formulations).

Availability

Pharmacies, Hospitals

Approval Status

Approved by major regulatory bodies (e.g., FDA, EMA, DGDA)

Patent Status

Generic available (original patent expired)

WHO Essential Medicine

Yes

Clinical Trials

Numerous clinical trials have established the efficacy and safety of esomeprazole in various acid-related disorders including GERD, gastric and duodenal ulcers, and Zollinger-Ellison syndrome. Studies have compared its effectiveness to other PPIs and H2-receptor antagonists.

Lab Monitoring

Magnesium levels (for long-term use)
Liver function tests (in patients with hepatic impairment)

Doctor Notes

Consider tapering dose for long-term PPI users to avoid rebound acid secretion upon discontinuation.
Educate patients on potential long-term risks, especially for elderly patients or those with multiple comorbidities.
Monitor magnesium levels periodically in patients on long-term therapy or concurrent diuretic use. Consider vitamin B12 supplementation for prolonged use.

Patient Guidelines

Inform your doctor about all existing medical conditions and medications, especially if you are taking nelfinavir, atazanavir, warfarin, clopidogrel, or methotrexate.
Report any unusual side effects or worsening of symptoms immediately.
Do not stop treatment abruptly without consulting your doctor.

Missed Dose Advice

Since this is an injection administered by a healthcare professional, a missed dose is unlikely. If a dose is missed, inform your doctor immediately to reschedule.

Driving Precautions

Esomeprazole may cause dizziness or visual disturbances in some patients. If you experience these symptoms, avoid driving or operating machinery until you know how the medicine affects you.