Expillin
Generic Name
Expillin-2-mg-Syrup
Manufacturer
MediCorp Pharma Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| expillin 2 mg syrup | ৳ 21.50 | N/A |
Description
Overview of the medicine
Expillin-2-mg-Syrup is an antihistamine primarily used to relieve symptoms of allergies such as allergic rhinitis, urticaria, and pruritus. It belongs to the first-generation antihistamine class and may cause drowsiness.
Uses & Indications
Dosage
Adults
5-10 ml (2-4 mg) three times daily. Maximum 6 mg (15 ml) per single dose. Maximum 12 mg (30 ml) in 24 hours.
Elderly
Start with a lower dose (e.g., 5 ml two times daily) due to increased susceptibility to side effects and reduced renal clearance. Adjust based on response and tolerability.
Renal_impairment
Use with caution. Dosage adjustment may be required; a reduced frequency or dose may be appropriate. Consult a physician.
How to Take
Expillin-2-mg-Syrup is for oral administration. It can be taken with or without food. Use the provided measuring cup to ensure accurate dosing.
Mechanism of Action
Expillin acts as a competitive antagonist of histamine at H1-receptors. It blocks the effects of histamine released during allergic reactions, thereby alleviating symptoms like sneezing, runny nose, itching, and watery eyes.
Pharmacokinetics
Onset
Onset of action typically occurs within 15-30 minutes.
Excretion
Excreted mainly via the kidneys, with a small amount excreted unchanged.
Half life
Plasma elimination half-life is approximately 4-6 hours.
Absorption
Rapidly absorbed from the gastrointestinal tract, with peak plasma concentrations occurring within 1-2 hours.
Metabolism
Primarily metabolized in the liver by cytochrome P450 enzymes.
Side Effects
Contraindications
- •Hypersensitivity to Expillin or any component of the syrup
- •Newborns or premature infants
- •Nursing mothers
- •Patients with lower respiratory tract symptoms, including asthma attacks
- •Concomitant use with Monoamine Oxidase Inhibitors (MAOIs) or within 14 days of stopping MAOI therapy
Drug Interactions
Monoamine Oxidase Inhibitors (MAOIs)
Can prolong and intensify the anticholinergic effects of Expillin, including severe hypotension and CNS depression.
CNS Depressants (e.g., alcohol, sedatives, hypnotics)
Increased sedative effect, potentially leading to severe drowsiness or respiratory depression.
Anticholinergic Drugs (e.g., tricyclic antidepressants, atropine)
Additive anticholinergic effects, leading to increased risk of dry mouth, blurred vision, urinary retention, and constipation.
Storage
Store below 30°C in a dry place. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include severe drowsiness, dizziness, confusion, blurred vision, dry mouth, urinary retention, dilated pupils, fever, flushing, and in severe cases, convulsions or coma. Management involves supportive and symptomatic care, including gastric lavage or activated charcoal if ingestion is recent. Monitor vital signs and maintain airway.
Pregnancy & Lactation
Pregnancy Category B. Use during pregnancy only if clearly needed. Not recommended for nursing mothers as it can be excreted in breast milk and may cause adverse effects in infants. Consult your doctor before use.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months from the date of manufacture when stored under recommended conditions.
Availability
Pharmacies nationwide
Approval Status
Approved by DGDA
Patent Status
Patent Expired
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Global Brand Names
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