Adults

The usual adult dose is 200 mg three times daily. The duration of treatment depends on the type and severity of the infection, usually 7 to 14 days.

Elderly

No specific dosage adjustment is generally required for elderly patients with normal renal function. However, dosage adjustment may be needed based on renal function.

Renal_impairment

For patients with severe renal impairment (creatinine clearance < 30 mL/min), the dose should be reduced to 150 mg twice daily. No adjustment needed for mild to moderate impairment.

Onset

Peak plasma concentrations are achieved within 1-2 hours after oral administration.

Excretion

Primarily excreted unchanged in the urine (approximately 70% within 12 hours).

Half life

The elimination half-life is approximately 1 hour.

Absorption

Rapidly absorbed after oral administration of Faropenem medoxomil (prodrug), which is hydrolyzed to Faropenem. Bioavailability is approximately 70%.

Metabolism

Faropenem medoxomil is hydrolyzed to Faropenem in the intestinal mucosa and blood. Faropenem itself undergoes limited metabolism, primarily in the kidneys.

Probenecid

Concomitant use with probenecid may increase Faropenem plasma concentrations and prolong its half-life by inhibiting renal excretion. This may lead to increased side effects.

Valproic Acid

Co-administration with carbapenems (including Faropenem) may decrease serum concentrations of valproic acid, potentially leading to subtherapeutic levels and loss of seizure control. Monitor valproic acid levels.