Favozyth
Generic Name
Azithromycin 200 mg/5 ml Suspension
Manufacturer
Favo Pharmaceutical Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| favozyth 200 mg suspension | ৳ 85.00 | N/A |
Description
Overview of the medicine
Favozyth 200 mg suspension is a macrolide antibiotic used to treat a variety of bacterial infections, including respiratory tract infections, skin and soft tissue infections, and sexually transmitted diseases. It works by stopping the growth of bacteria.
Uses & Indications
Dosage
Adults
For most infections: 500 mg once daily for 3 days or 500 mg on day 1, then 250 mg once daily for 4 days. For STDs: 1 gm single dose.
Elderly
No specific dosage adjustment is required in elderly patients, unless they have severe renal or hepatic impairment.
Renal_impairment
Mild to moderate renal impairment (creatinine clearance >10-80 mL/min): No dosage adjustment needed. Severe renal impairment (creatinine clearance <10 mL/min): Use with caution, dosage adjustment may be necessary.
How to Take
Shake the bottle well before each use. Take the medicine orally, with or without food, as directed by your doctor. Use the provided measuring device to ensure accurate dosage. Complete the full course of treatment.
Mechanism of Action
Azithromycin, the active ingredient in Favozyth, works by inhibiting bacterial protein synthesis. It binds to the 50S ribosomal subunit of susceptible microorganisms, thereby preventing translocation of peptide chains and inhibiting RNA-dependent protein synthesis.
Pharmacokinetics
Onset
Clinical effects usually within 2-3 days of initiation.
Excretion
Mainly excreted unchanged in the bile (approximately 50% of an oral dose). A small portion is excreted in the urine.
Half life
Terminal elimination half-life is 2-4 days.
Absorption
Rapidly absorbed from the gastrointestinal tract; however, bioavailability is approximately 37% due to significant first-pass metabolism. Peak plasma concentrations are reached within 2-3 hours.
Metabolism
Primarily metabolized in the liver, largely to inactive metabolites, via N-demethylation.
Side Effects
Contraindications
- Hypersensitivity to azithromycin, erythromycin, any macrolide or ketolide antibiotic, or any component of the formulation.
- History of cholestatic jaundice/hepatic dysfunction associated with prior azithromycin use.
Drug Interactions
Warfarin
May increase the anticoagulant effect. Monitor INR closely.
Nelfinavir
May increase azithromycin serum concentrations. Monitor for increased side effects.
Antacids containing aluminum or magnesium
May decrease peak serum levels of azithromycin. Take azithromycin at least 1 hour before or 2 hours after antacids.
QT-prolonging drugs (e.g., Amiodarone, Sotalol)
Increased risk of QT prolongation and Torsades de Pointes. Avoid co-administration if possible.
Storage
Store dry powder below 30°C in a dry place, away from light. Do not freeze reconstituted suspension.
Overdose
Symptoms of overdose may include severe nausea, vomiting, diarrhea, and reversible hearing loss. Treatment is supportive and symptomatic; gastric lavage and general supportive measures may be indicated.
Pregnancy & Lactation
Pregnancy Category B. Use only if clearly needed. Azithromycin is excreted in breast milk; consult your doctor before breastfeeding.
Side Effects
Contraindications
- Hypersensitivity to azithromycin, erythromycin, any macrolide or ketolide antibiotic, or any component of the formulation.
- History of cholestatic jaundice/hepatic dysfunction associated with prior azithromycin use.
Drug Interactions
Warfarin
May increase the anticoagulant effect. Monitor INR closely.
Nelfinavir
May increase azithromycin serum concentrations. Monitor for increased side effects.
Antacids containing aluminum or magnesium
May decrease peak serum levels of azithromycin. Take azithromycin at least 1 hour before or 2 hours after antacids.
QT-prolonging drugs (e.g., Amiodarone, Sotalol)
Increased risk of QT prolongation and Torsades de Pointes. Avoid co-administration if possible.
Storage
Store dry powder below 30°C in a dry place, away from light. Do not freeze reconstituted suspension.
Overdose
Symptoms of overdose may include severe nausea, vomiting, diarrhea, and reversible hearing loss. Treatment is supportive and symptomatic; gastric lavage and general supportive measures may be indicated.
Pregnancy & Lactation
Pregnancy Category B. Use only if clearly needed. Azithromycin is excreted in breast milk; consult your doctor before breastfeeding.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months (unreconstituted powder). Reconstituted suspension is stable for 5 days at room temperature.
Availability
Pharmacies, hospitals
Approval Status
Approved by regulatory authorities
Patent Status
Generic available
WHO Essential Medicine
YesClinical Trials
Numerous clinical trials have established azithromycin's efficacy and safety in various bacterial infections, including pediatric populations. Ongoing research continues to explore its potential uses and optimize treatment regimens.
Lab Monitoring
- Liver function tests (LFTs) if treatment is prolonged or in patients with pre-existing hepatic impairment.
- Renal function tests if severe renal impairment is suspected.
Doctor Notes
- Emphasize completing the full course to prevent resistance and ensure eradication.
- Counsel patients on potential GI side effects and advise taking with food if severe.
- Be aware of QT prolongation risk, especially in patients with pre-existing cardiac conditions or on interacting medications.
Patient Guidelines
- Complete the entire prescribed course of medicine, even if symptoms improve.
- Shake the suspension bottle well before each use.
- Use the provided measuring spoon or cup for accurate dosing.
- Do not save unused medicine for future infections.
- Inform your doctor about any pre-existing conditions or other medications you are taking.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.
Driving Precautions
Favozyth generally does not impair the ability to drive or operate machinery. However, if you experience dizziness or visual disturbances, avoid such activities.
Lifestyle Advice
- Maintain good hydration during treatment.
- Avoid alcohol consumption, especially if experiencing gastrointestinal side effects.
- Follow a balanced diet.
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