Febuxit
Generic Name
Febuxostat
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| febuxit 40 mg tablet | ৳ 12.00 | ৳ 168.00 |
Description
Overview of the medicine
Febuxostat 40 mg tablet is a medicine used to lower high uric acid levels (hyperuricemia) in patients with chronic gout. It helps to prevent gout attacks.
Uses & Indications
Dosage
Adults
Initial dose is 40 mg once daily. If serum uric acid is > 6 mg/dL after 2 weeks, the dose may be increased to 80 mg once daily. Prophylaxis for gout flares should be considered upon initiation of therapy.
Elderly
No dosage adjustment is required for elderly patients.
Renal_impairment
No dosage adjustment is necessary for mild to moderate renal impairment. Use with caution in severe renal impairment (creatinine clearance < 30 mL/min).
How to Take
Take orally once daily, with or without food.
Mechanism of Action
Febuxostat is a xanthine oxidase inhibitor. It works by blocking the enzyme xanthine oxidase, which is responsible for the production of uric acid in the body. By inhibiting this enzyme, febuxostat effectively lowers serum uric acid levels.
Pharmacokinetics
Onset
Uric acid lowering effect begins within 1 hour.
Excretion
Excreted via both renal and hepatic routes.
Half life
Mean plasma elimination half-life is approximately 5-8 hours.
Absorption
Rapidly and well absorbed orally. Peak plasma concentration (Cmax) achieved in approximately 1 hour. Food does not significantly affect the extent of absorption.
Metabolism
Extensively metabolized in the liver via oxidation and glucuronidation pathways.
Side Effects
Contraindications
- Hypersensitivity to febuxostat or any excipients.
- Concomitant use with azathioprine or mercaptopurine.
- Concomitant use with theophylline.
Drug Interactions
Theophylline
Febuxostat may increase plasma concentrations of theophylline; concomitant use is contraindicated.
Azathioprine / Mercaptopurine
Febuxostat may cause increased plasma concentrations and toxicity of these drugs; concomitant use is contraindicated.
Storage
Store below 30°C in a dry and cool place, protected from light and moisture. Keep out of reach of children.
Overdose
In case of overdose, no specific antidote is available. Management should be symptomatic and supportive.
Pregnancy & Lactation
Not recommended during pregnancy and lactation unless clearly necessary and advised by a doctor. Animal studies have shown adverse effects on the fetus.
Side Effects
Contraindications
- Hypersensitivity to febuxostat or any excipients.
- Concomitant use with azathioprine or mercaptopurine.
- Concomitant use with theophylline.
Drug Interactions
Theophylline
Febuxostat may increase plasma concentrations of theophylline; concomitant use is contraindicated.
Azathioprine / Mercaptopurine
Febuxostat may cause increased plasma concentrations and toxicity of these drugs; concomitant use is contraindicated.
Storage
Store below 30°C in a dry and cool place, protected from light and moisture. Keep out of reach of children.
Overdose
In case of overdose, no specific antidote is available. Management should be symptomatic and supportive.
Pregnancy & Lactation
Not recommended during pregnancy and lactation unless clearly necessary and advised by a doctor. Animal studies have shown adverse effects on the fetus.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
2-3 years from manufacturing date
Availability
Pharmacies, hospitals
Approval Status
Approved
Patent Status
Generic available
Clinical Trials
Extensive clinical trials have established the efficacy and safety of febuxostat in lowering serum uric acid in patients with chronic gout.
Lab Monitoring
- Monitor serum uric acid levels before and periodically during treatment.
- Periodically monitor liver function tests (LFTs).
Doctor Notes
- Monitor liver function tests (LFTs) and serum uric acid levels regularly before and during treatment.
- Counsel patients about the possibility of initial gout flares; consider prophylaxis with colchicine or NSAIDs.
Patient Guidelines
- Take this medicine regularly as directed by your doctor, even if you feel well.
- Gout flares may occur during the initial months of treatment; this is normal, and do not stop the medication. Your doctor may prescribe additional medication for pain relief.
- Report any unusual side effects or symptoms to your doctor.
Missed Dose Advice
If a dose is missed, take it as soon as you remember, unless it is almost time for your next dose. Do not double the dose to make up for a missed one.
Driving Precautions
Febuxostat may cause dizziness, somnolence, or blurred vision in some patients. If you experience these side effects, avoid driving or operating heavy machinery.
Lifestyle Advice
- Maintain good hydration by drinking plenty of water.
- Avoid purine-rich foods (e.g., red meat, organ meats, seafood) and limit alcohol intake.
- Maintain a healthy weight and exercise regularly.
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