Febuxit
Generic Name
Febuxostat
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| febuxit 80 mg tablet | ৳ 22.00 | ৳ 308.00 |
Description
Overview of the medicine
Febuxostat is a xanthine oxidase inhibitor used to treat chronic hyperuricemia in patients with gout.
Uses & Indications
Dosage
Adults
Initial 40 mg once daily; if serum uric acid is >6 mg/dL after 2 weeks, increase to 80 mg once daily.
Elderly
No dose adjustment required.
Renal_impairment
Mild to moderate: No dose adjustment. Severe: Use with caution, consider 40 mg initially.
How to Take
Oral, once daily, with or without food.
Mechanism of Action
It works by inhibiting xanthine oxidase, an enzyme involved in uric acid synthesis, thereby lowering serum uric acid levels.
Pharmacokinetics
Onset
Uric acid lowering effect seen within 2 weeks.
Excretion
Both renal (approximately 49%) and fecal (approximately 45%) excretion.
Half life
Approximately 5-8 hours.
Absorption
Rapidly absorbed after oral administration. Tmax 1-1.5 hours.
Metabolism
Extensively metabolized in the liver via oxidation and glucuronidation.
Side Effects
Contraindications
- Hypersensitivity to febuxostat or any excipients.
- Concomitant use with azathioprine, mercaptopurine, or theophylline.
Drug Interactions
Warfarin
Increased INR reported, monitor coagulation.
Theophylline
Increased plasma concentrations of theophylline.
Azathioprine/Mercaptopurine
Increased plasma concentrations, potentially leading to severe myelosuppression.
Storage
Store below 30°C, protected from light and moisture.
Overdose
Symptomatic and supportive treatment.
Pregnancy & Lactation
Not recommended during pregnancy or breastfeeding.
Side Effects
Contraindications
- Hypersensitivity to febuxostat or any excipients.
- Concomitant use with azathioprine, mercaptopurine, or theophylline.
Drug Interactions
Warfarin
Increased INR reported, monitor coagulation.
Theophylline
Increased plasma concentrations of theophylline.
Azathioprine/Mercaptopurine
Increased plasma concentrations, potentially leading to severe myelosuppression.
Storage
Store below 30°C, protected from light and moisture.
Overdose
Symptomatic and supportive treatment.
Pregnancy & Lactation
Not recommended during pregnancy or breastfeeding.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months
Availability
Pharmacies nationwide
Approval Status
Approved
Patent Status
Generic available
Clinical Trials
Data from CARES and FAST studies. Ongoing studies continue to evaluate long-term cardiovascular safety.
Lab Monitoring
- Serum uric acid levels (initial and periodically).
- Liver function tests (baseline and periodically).
Doctor Notes
- Initiate treatment with 40 mg and titrate up to 80 mg if needed to achieve target serum uric acid levels (<6 mg/dL).
- Monitor LFTs and serum uric acid regularly (e.g., at 2 and 4 weeks initially, then periodically).
- Consider cardiovascular risk factors before and during treatment.
Patient Guidelines
- Do not stop taking the medicine without consulting your doctor, even if you feel better.
- Drink plenty of water to help prevent kidney stones.
- Report any new or worsening symptoms to your doctor.
Missed Dose Advice
Take the missed dose as soon as you remember. If it's near the time for your next dose, skip the missed dose. Do not double dose.
Driving Precautions
May cause dizziness or drowsiness; caution advised.
Lifestyle Advice
- Maintain a healthy diet, avoiding purine-rich foods.
- Limit alcohol intake.
Alternative Medicines in Bangladesh
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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