Feluric
Generic Name
Febuxostat 80 mg tablet
Manufacturer
Reputable Pharmaceutical Company
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| feluric 80 mg tablet | ৳ 22.00 | ৳ 220.00 |
Description
Overview of the medicine
Feluric 80 mg tablet contains Febuxostat, a xanthine oxidase inhibitor used to lower uric acid levels in the blood. It is prescribed for the long-term management of chronic hyperuricemia in adult patients with gout.
Uses & Indications
Dosage
Adults
Initial dose is 40 mg once daily. If serum uric acid is not <6 mg/dL after 2 weeks, increase to 80 mg once daily. Maximum recommended dose is 120 mg once daily.
Elderly
No dosage adjustment required.
Renal_impairment
Mild to moderate renal impairment: No dosage adjustment required. Severe renal impairment: Limited data, caution advised.
How to Take
Feluric 80 mg tablet should be taken orally, once daily, with or without food. It should be swallowed whole with water.
Mechanism of Action
Febuxostat selectively inhibits xanthine oxidase, an enzyme involved in purine metabolism that catalyzes the oxidation of hypoxanthine to xanthine and xanthine to uric acid. By inhibiting this enzyme, Febuxostat reduces the production of uric acid, thereby lowering serum uric acid levels.
Pharmacokinetics
Onset
Reduction in serum uric acid levels usually observed within 2 weeks of initiation.
Excretion
Approximately 49% of the dose is excreted via the renal pathway and 45% via the fecal pathway.
Half life
Approximately 5 to 8 hours.
Absorption
Rapidly and well absorbed after oral administration, with peak plasma concentrations occurring 1-1.5 hours post-dose. Absorption is not significantly affected by food.
Metabolism
Extensively metabolized in the liver via conjugation (primarily with UDP-glucuronosyltransferase) and oxidation (via CYP1A2, 2C8, 2C9, and non-CYP enzymes).
Side Effects
Contraindications
- •Hypersensitivity to Febuxostat or any excipients.
- •Patients receiving azathioprine, mercaptopurine, or theophylline (due to potential for increased plasma concentrations of these drugs).
Drug Interactions
Antacids
No clinically significant interaction with antacids.
Theophylline
Febuxostat may increase the plasma concentration of theophylline. Monitoring of theophylline levels is recommended.
Azathioprine, Mercaptopurine
Febuxostat inhibits xanthine oxidase, which is involved in the metabolism of these drugs. Co-administration can lead to increased plasma concentrations and toxicity of azathioprine and mercaptopurine. Concomitant use is contraindicated.
Storage
Store below 30°C in a dry place, away from direct light and moisture. Keep out of reach of children.
Overdose
Limited information on Febuxostat overdose. In case of overdose, symptomatic and supportive treatment should be provided. There is no specific antidote.
Pregnancy & Lactation
Pregnancy Category C. Febuxostat should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. It is not known whether Febuxostat is excreted in human milk; caution should be exercised when administered to a nursing woman.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24 to 36 months from the date of manufacture.
Availability
Available in pharmacies nationwide
Approval Status
Approved by major regulatory bodies (e.g., FDA, EMA, DGDA)
Patent Status
Generic versions available
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Global Brand Names
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