Feva
Generic Name
Paracetamol 500 mg Tablet
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| feva 500 mg tablet | ৳ 1.20 | ৳ 12.00 |
Description
Overview of the medicine
Feva 500 mg Tablet contains Paracetamol, a widely used medication for the relief of mild to moderate pain and fever. It works by inhibiting prostaglandin synthesis in the central nervous system, reducing pain and fever.
Uses & Indications
Dosage
Adults
500 mg to 1000 mg (1-2 tablets) every 4-6 hours as needed, not exceeding 4000 mg (8 tablets) in 24 hours.
Elderly
Same as adult dose; caution advised in patients with impaired renal or hepatic function.
Renal_impairment
Dose adjustment may be necessary in severe renal impairment. Consult a physician.
How to Take
Oral administration. Tablets should be swallowed with water. Can be taken with or without food. Do not exceed recommended dose.
Mechanism of Action
Paracetamol's exact mechanism is not fully understood, but it is believed to act primarily in the central nervous system by inhibiting prostaglandin synthesis through a COX-3 like mechanism, leading to analgesic and antipyretic effects. It has minimal anti-inflammatory activity.
Pharmacokinetics
Onset
30-60 minutes for analgesia; 30 minutes for antipyresis.
Excretion
Mainly excreted in the urine as glucuronide and sulfate conjugates. Less than 5% is excreted unchanged.
Half life
Approximately 1.5 to 3 hours; slightly prolonged in hepatic dysfunction or overdose.
Absorption
Rapidly and almost completely absorbed from the gastrointestinal tract, primarily in the small intestine. Peak plasma concentrations are reached within 30-60 minutes.
Metabolism
Primarily metabolized in the liver by conjugation with glucuronide and sulfate. A small portion is metabolized by cytochrome P450 into a highly reactive intermediate (NAPQI), which is normally detoxified by glutathione. In overdose, glutathione stores are depleted, leading to liver damage.
Side Effects
Contraindications
- Hypersensitivity to paracetamol or any component of the formulation
- Severe hepatic impairment or active liver disease
Drug Interactions
Alcohol
Increases risk of liver damage, especially with chronic heavy alcohol consumption.
Cholestyramine
Reduces paracetamol absorption.
Metoclopramide, Domperidone
Increases paracetamol absorption rate.
Warfarin and other coumarins
May increase anticoagulant effect, leading to increased bleeding risk with prolonged regular use.
Isoniazid, Rifampicin, Carbamazepine, Phenytoin
May increase risk of paracetamol hepatotoxicity by inducing liver enzymes.
Storage
Store below 30°C in a dry place, away from direct light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include nausea, vomiting, abdominal pain, sweating, and malaise, which may be followed by liver damage (jaundice, liver tenderness) in 24-48 hours. Seek immediate medical attention. Treatment involves gastric lavage, activated charcoal, and N-acetylcysteine (NAC) intravenously or orally.
Pregnancy & Lactation
Considered safe for use during pregnancy and lactation when used at recommended doses for short periods. It is the preferred analgesic/antipyretic in pregnancy. Consult a doctor before use.
Side Effects
Contraindications
- Hypersensitivity to paracetamol or any component of the formulation
- Severe hepatic impairment or active liver disease
Drug Interactions
Alcohol
Increases risk of liver damage, especially with chronic heavy alcohol consumption.
Cholestyramine
Reduces paracetamol absorption.
Metoclopramide, Domperidone
Increases paracetamol absorption rate.
Warfarin and other coumarins
May increase anticoagulant effect, leading to increased bleeding risk with prolonged regular use.
Isoniazid, Rifampicin, Carbamazepine, Phenytoin
May increase risk of paracetamol hepatotoxicity by inducing liver enzymes.
Storage
Store below 30°C in a dry place, away from direct light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include nausea, vomiting, abdominal pain, sweating, and malaise, which may be followed by liver damage (jaundice, liver tenderness) in 24-48 hours. Seek immediate medical attention. Treatment involves gastric lavage, activated charcoal, and N-acetylcysteine (NAC) intravenously or orally.
Pregnancy & Lactation
Considered safe for use during pregnancy and lactation when used at recommended doses for short periods. It is the preferred analgesic/antipyretic in pregnancy. Consult a doctor before use.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from the date of manufacture. Check the expiry date on the packaging.
Availability
Pharmacies, supermarkets, general stores
Approval Status
Approved by major regulatory bodies globally (e.g., FDA, DGDA)
Patent Status
Generic; patent expired long ago
WHO Essential Medicine
YesClinical Trials
Paracetamol is a well-established drug with extensive clinical trial data over decades confirming its efficacy and safety profile for pain and fever relief. Ongoing research explores its precise mechanisms and potential new applications.
Lab Monitoring
- Liver function tests (ALT, AST, bilirubin) in cases of chronic use or suspected overdose
- Renal function tests (creatinine) in patients with kidney impairment
Doctor Notes
- Emphasize strict adherence to dosage to prevent liver toxicity.
- Advise patients about potential for other OTC products containing paracetamol.
- Caution in patients with chronic liver disease, severe renal impairment, or chronic alcoholics.
Patient Guidelines
- Do not exceed the recommended dose.
- Avoid taking other paracetamol-containing products simultaneously.
- Consult a doctor if pain or fever persists for more than a few days.
- Keep out of reach of children.
Missed Dose Advice
If you miss a dose, take it as soon as you remember, unless it is almost time for your next dose. Do not take a double dose to make up for a missed one. Continue with your regular dosing schedule.
Driving Precautions
Paracetamol generally does not impair ability to drive or operate machinery. However, if you experience dizziness or side effects, avoid these activities.
Lifestyle Advice
- Stay hydrated, especially when treating fever.
- Get adequate rest to aid recovery.
- Avoid alcohol consumption while on medication, especially with chronic use.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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