Feva
Generic Name
Paracetamol (Acetaminophen) 80 mg Pediatric Drop
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| feva 80 mg pediatric drop | ৳ 20.00 | N/A |
Description
Overview of the medicine
Feva 80 mg Pediatric Drop is used for the symptomatic treatment of mild to moderate pain and fever in infants and young children.
Uses & Indications
Dosage
Adults
Not for adult use in this formulation. Adults typically use higher strength tablets or syrups.
Elderly
Not for elderly use in this formulation.
Renal_impairment
Use with caution in severe renal impairment. Dose adjustment may be necessary for creatinine clearance <10 mL/min.
Pediatric_0-3_months
10-15 mg/kg body weight, every 4-6 hours as needed. Max 60 mg/kg/day. For 0-3 months, consult a doctor.
Pediatric_3-12_months
10-15 mg/kg body weight, every 4-6 hours as needed. Max 60 mg/kg/day. E.g., for a 5 kg infant, 0.6 mL (48 mg) to 0.9 mL (72 mg) per dose. Do not exceed 4 doses in 24 hours.
How to Take
Administer orally using the calibrated dropper provided. Do not exceed the recommended dose and dosing interval. Can be given with or without food.
Mechanism of Action
Paracetamol exerts its analgesic and antipyretic effects by inhibiting prostaglandin synthesis, primarily in the central nervous system.
Pharmacokinetics
Onset
Analgesic effect begins within 30-60 minutes, antipyretic effect within 30 minutes.
Excretion
Mainly excreted in the urine as glucuronide and sulfate conjugates. Less than 5% is excreted unchanged.
Half life
Plasma elimination half-life is 1-4 hours (typically 2-3 hours) in healthy individuals.
Absorption
Rapidly and almost completely absorbed from the gastrointestinal tract, with peak plasma concentrations occurring within 30-60 minutes.
Metabolism
Primarily metabolized in the liver via glucuronidation and sulfation, and a small amount via cytochrome P450 pathway to a toxic intermediate (NAPQI) which is rapidly detoxified by glutathione.
Side Effects
Contraindications
- Hypersensitivity to paracetamol or any component of the formulation
- Severe hepatic impairment or active liver disease
Drug Interactions
Warfarin
May increase the anticoagulant effect, leading to a higher risk of bleeding, especially with prolonged daily use.
Cholestyramine
May decrease the absorption of paracetamol if given within one hour.
Metoclopramide, Domperidone
May increase the absorption rate of paracetamol.
Carbamazepine, Phenobarbital, Phenytoin
May increase the risk of hepatotoxicity due to enzyme induction.
Storage
Store below 30°C. Protect from light and moisture. Do not freeze. Keep the bottle tightly closed.
Overdose
Symptoms of overdose include nausea, vomiting, abdominal pain, pallor, and sweating. Severe overdose can lead to hepatic necrosis and renal tubular necrosis. Treatment involves gastric lavage, activated charcoal, and administration of N-acetylcysteine (NAC) as an antidote.
Pregnancy & Lactation
While this is a pediatric formulation, paracetamol is generally considered safe for use during pregnancy and lactation when used at recommended doses. Consult a healthcare professional before use.
Side Effects
Contraindications
- Hypersensitivity to paracetamol or any component of the formulation
- Severe hepatic impairment or active liver disease
Drug Interactions
Warfarin
May increase the anticoagulant effect, leading to a higher risk of bleeding, especially with prolonged daily use.
Cholestyramine
May decrease the absorption of paracetamol if given within one hour.
Metoclopramide, Domperidone
May increase the absorption rate of paracetamol.
Carbamazepine, Phenobarbital, Phenytoin
May increase the risk of hepatotoxicity due to enzyme induction.
Storage
Store below 30°C. Protect from light and moisture. Do not freeze. Keep the bottle tightly closed.
Overdose
Symptoms of overdose include nausea, vomiting, abdominal pain, pallor, and sweating. Severe overdose can lead to hepatic necrosis and renal tubular necrosis. Treatment involves gastric lavage, activated charcoal, and administration of N-acetylcysteine (NAC) as an antidote.
Pregnancy & Lactation
While this is a pediatric formulation, paracetamol is generally considered safe for use during pregnancy and lactation when used at recommended doses. Consult a healthcare professional before use.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from the date of manufacture when stored under recommended conditions.
Availability
Available in pharmacies, drug stores, and some supermarkets
Approval Status
Widely approved globally
Patent Status
Patent expired
WHO Essential Medicine
YesClinical Trials
Numerous clinical trials and studies have established the efficacy and safety of paracetamol as an analgesic and antipyretic in pediatric populations.
Lab Monitoring
- Liver function tests (ALT, AST, bilirubin) in cases of suspected overdose or prolonged high-dose therapy.
- Serum paracetamol levels in overdose situations.
Doctor Notes
- Educate parents on accurate dosing using the calibrated dropper and the importance of not exceeding the maximum daily dose.
- Advise parents to seek medical attention if symptoms persist or worsen.
- Counsel on potential signs of overdose (e.g., nausea, vomiting, lethargy) and the need for immediate medical evaluation.
Patient Guidelines
- Always use the provided calibrated dropper for accurate dosing.
- Do not exceed the recommended dose or frequency.
- Consult a doctor if fever persists for more than 3 days or pain for more than 5 days.
- Keep out of reach of children.
Missed Dose Advice
If a dose is missed, administer it as soon as remembered. However, if it is almost time for the next dose, skip the missed dose and continue with the regular dosing schedule. Do not double the dose.
Driving Precautions
Not applicable for pediatric patients. For adults, paracetamol typically does not impair the ability to drive or operate machinery.
Lifestyle Advice
- Ensure adequate hydration for the child when they have fever.
- Dress the child in light clothing to help regulate body temperature.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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