Fexen
Generic Name
Fexofenadine Hydrochloride
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| fexen 180 mg tablet | ৳ 10.00 | ৳ 100.00 |
Description
Overview of the medicine
Fexofenadine is a non-sedating antihistamine used to relieve symptoms of seasonal allergic rhinitis (hay fever) and chronic idiopathic urticaria (hives).
Uses & Indications
Dosage
Adults
Seasonal Allergic Rhinitis: 180 mg once daily. Chronic Idiopathic Urticaria: 180 mg once daily.
Elderly
No specific dosage adjustment is recommended, but caution is advised in elderly patients with impaired renal function.
Renal_impairment
For patients with impaired renal function (creatinine clearance ≤ 80 mL/min), initial dose should be 60 mg once daily.
How to Take
Take orally with water, preferably before a meal, as food may reduce absorption.
Mechanism of Action
Fexofenadine is a selective peripheral H1-receptor antagonist. It blocks the effects of histamine by competitively inhibiting histamine H1-receptors on effector cells, thereby reducing allergic symptoms without causing significant central nervous system effects like sedation.
Pharmacokinetics
Onset
Onset of action is approximately 1 hour.
Excretion
Excreted primarily unchanged in feces (80%) and urine (11%).
Half life
Plasma elimination half-life is approximately 11-15 hours.
Absorption
Rapidly absorbed after oral administration. Peak plasma concentrations are reached in 2-3 hours. Bioavailability is approximately 33%.
Metabolism
Minimally metabolized (approximately 5% by hepatic metabolism).
Side Effects
Contraindications
- Known hypersensitivity to fexofenadine or any excipients of the tablet.
Drug Interactions
Erythromycin or Ketoconazole
May increase plasma levels of fexofenadine, but generally without increasing side effects.
Fruit juices (grapefruit, orange, apple)
May reduce the bioavailability of fexofenadine. Avoid taking with these juices.
Antacids containing aluminum or magnesium
May reduce the absorption of fexofenadine. Separate administration by at least 2 hours.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include drowsiness, dizziness, and dry mouth. Treatment should be symptomatic and supportive, including gastric lavage and activated charcoal if appropriate.
Pregnancy & Lactation
Pregnancy Category C. Should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Not recommended during breastfeeding as it is excreted in breast milk.
Side Effects
Contraindications
- Known hypersensitivity to fexofenadine or any excipients of the tablet.
Drug Interactions
Erythromycin or Ketoconazole
May increase plasma levels of fexofenadine, but generally without increasing side effects.
Fruit juices (grapefruit, orange, apple)
May reduce the bioavailability of fexofenadine. Avoid taking with these juices.
Antacids containing aluminum or magnesium
May reduce the absorption of fexofenadine. Separate administration by at least 2 hours.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include drowsiness, dizziness, and dry mouth. Treatment should be symptomatic and supportive, including gastric lavage and activated charcoal if appropriate.
Pregnancy & Lactation
Pregnancy Category C. Should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Not recommended during breastfeeding as it is excreted in breast milk.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
2-3 years from manufacturing date
Availability
Available in pharmacies and hospitals
Approval Status
Approved by major regulatory bodies (e.g., FDA, DGDA)
Patent Status
Generic (Patent Expired)
Clinical Trials
Extensive clinical trials have established the efficacy and safety of fexofenadine for seasonal allergic rhinitis and chronic idiopathic urticaria. Ongoing research may explore new indications or formulations.
Lab Monitoring
- No routine laboratory monitoring is typically required.
- Monitor renal function in patients with renal impairment.
Doctor Notes
- Advise patients to avoid taking fexofenadine with fruit juices (grapefruit, orange, apple) due to reduced bioavailability.
- Consider reduced dosage in patients with renal impairment.
- Reassure patients about the non-sedating nature, but advise caution for individual variability.
Patient Guidelines
- Take this medicine exactly as prescribed by your doctor.
- Do not take more than the recommended dose.
- Avoid taking with fruit juices (grapefruit, orange, apple).
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
Fexofenadine is generally non-sedating, but individual response may vary. Exercise caution when driving or operating machinery until you know how this medicine affects you.
Lifestyle Advice
- Identify and avoid known allergens that trigger your symptoms.
- Maintain good hydration.
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