Finapark
Generic Name
Venlafaxine
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| finapark 50 mg tablet | ৳ 25.00 | ৳ 250.00 |
Description
Overview of the medicine
Finapark (Venlafaxine) is a serotonin and norepinephrine reuptake inhibitor (SNRI) used to treat major depressive disorder, generalized anxiety disorder, social anxiety disorder, and panic disorder. It works by affecting chemical messengers in the brain that communicate between brain cells.
Uses & Indications
Dosage
Adults
For Major Depressive Disorder (IR tablets): Initially 25-50 mg orally twice daily, or 37.5 mg three times daily. May be increased by 50 mg/day every 4-7 days, up to a maximum of 225 mg/day. For severe or hospitalized patients, up to 375 mg/day in 3 divided doses. Always follow physician's advice.
Elderly
No specific dose adjustments are required based on age alone, but caution is advised due to potential for reduced renal or hepatic function. Lower initial doses and slower titration may be considered.
Renal_impairment
Moderate renal impairment (GFR 10-70 mL/min): Reduce total daily dose by 25-50%. Severe renal impairment (GFR <10 mL/min) or hemodialysis: Reduce total daily dose by 50%. Administer after dialysis.
How to Take
Take Finapark tablets orally with food to minimize gastrointestinal upset. Swallow the immediate-release tablet whole; do not crush, chew, or divide.
Mechanism of Action
Venlafaxine and its active metabolite, O-desmethylvenlafaxine (ODV), potentiate neurotransmitter activity in the CNS. They work by inhibiting the reuptake of both serotonin and norepinephrine, and weakly inhibiting dopamine reuptake. This increases the concentration of these neurotransmitters in the synaptic cleft, leading to antidepressant and anxiolytic effects.
Pharmacokinetics
Onset
Initial antidepressant effects may be observed within 2-4 weeks. Full therapeutic effect may take several weeks.
Excretion
Approximately 87% of a venlafaxine dose is excreted in the urine within 48 hours, mainly as ODV (59%), unconjugated venlafaxine (4%), and other minor metabolites.
Half life
Venlafaxine: approximately 5 hours; O-desmethylvenlafaxine (ODV): approximately 11 hours.
Absorption
Well absorbed from the gastrointestinal tract, with absolute bioavailability of about 45% due to presystemic metabolism. Peak plasma concentrations (Cmax) of venlafaxine are reached in approximately 2-4 hours for immediate-release (IR) formulations.
Metabolism
Primarily hepatic via cytochrome P450 (CYP2D6) to O-desmethylvenlafaxine (ODV), which is an active metabolite. Other minor pathways involve CYP3A4, CYP2C19, and CYP1A2.
Side Effects
Contraindications
- •Hypersensitivity to venlafaxine, O-desmethylvenlafaxine, or any excipients in the formulation.
- •Concomitant use with Monoamine Oxidase Inhibitors (MAOIs) or within 14 days of discontinuing MAOI treatment (risk of serotonin syndrome).
- •Uncontrolled narrow-angle glaucoma.
Drug Interactions
MAOIs
Concomitant use is contraindicated due to increased risk of serotonin syndrome, which can be fatal. Allow at least 14 days between discontinuing an MAOI and starting venlafaxine, and at least 7 days between discontinuing venlafaxine and starting an MAOI.
Warfarin
Altered anticoagulant effects, including increased prothrombin time, INR, and bleeding. Monitor coagulation parameters closely.
CNS Depressants (e.g., Alcohol, Benzodiazepines)
Increased CNS depressant effects. Avoid concomitant use with alcohol.
CYP2D6 inhibitors (e.g., Quinidine, Paroxetine, Fluoxetine)
May increase venlafaxine plasma concentrations and decrease ODV concentrations. Dose adjustment may be necessary.
Serotonergic drugs (e.g., SSRIs, SNRIs, Triptans, Tramadol)
Increased risk of serotonin syndrome. Monitor patients for symptoms.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include somnolence, mild tachycardia, mydriasis, convulsions, vomiting, and ECG changes (e.g., QT prolongation, bundle branch block, QRS prolongation). Rarely, fatalities have occurred. Management involves general supportive measures, maintaining an open airway, and monitoring cardiac rhythm and vital signs. Activated charcoal may be useful.
Pregnancy & Lactation
Pregnancy Category C. Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. Neonates exposed to SSRIs or SNRIs late in the third trimester have developed complications requiring prolonged hospitalization, respiratory support, and tube feeding. Venlafaxine and ODV are excreted in human breast milk; therefore, Finapark is not recommended for nursing mothers.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24 months from the date of manufacture, when stored under recommended conditions.
Availability
Pharmacies, Hospitals
Approval Status
Approved
Patent Status
Expired
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