Fix-A
Generic Name
Cefixime
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
Loading images...
Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| fix a 100 mg suspension | ৳ 155.00 | N/A |
Description
Overview of the medicine
Fix-A 100 mg Suspension is an oral antibiotic belonging to the cephalosporin group, used to treat various bacterial infections in children, including respiratory tract infections, urinary tract infections, and otitis media.
Uses & Indications
Dosage
Children
Children 6 months to 12 years: 8 mg/kg/day, given as a single daily dose or in two divided doses (4 mg/kg every 12 hours). Max 400 mg/day.
Renal_impairment
Creatinine clearance 21-60 ml/min: 75% of standard daily dose. Creatinine clearance <20 ml/min: 50% of standard daily dose.
How to Take
Administer orally with or without food. Shake the suspension well before each use. Use an accurate measuring device (e.g., oral syringe) for precise dosing.
Mechanism of Action
Cefixime inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), leading to bacterial cell lysis and death. It is bactericidal.
Pharmacokinetics
Onset
Peak plasma concentrations reached within 2-6 hours after oral administration.
Excretion
Primarily excreted unchanged in urine via glomerular filtration and tubular secretion, and also some via bile.
Half life
Approximately 3-4 hours.
Absorption
Approximately 40-50% orally absorbed. Food slightly delays absorption but does not significantly affect the extent.
Metabolism
Minimal metabolism; primarily excreted as unchanged drug.
Side Effects
Contraindications
- Hypersensitivity to cefixime or any other cephalosporin antibiotics
- History of serious hypersensitivity reactions to penicillin (due to potential cross-reactivity)
Drug Interactions
Warfarin
May enhance anticoagulant effect, increasing risk of bleeding. Monitor INR closely.
Probenecid
May increase cefixime plasma levels and prolong its duration of action.
Carbamazepine
Concomitant use may increase carbamazepine levels.
Storage
Store dry powder at controlled room temperature (20-25°C). After reconstitution, store in a refrigerator (2-8°C) and discard unused portion after 14 days (or as per label instructions).
Overdose
Symptoms may include nausea, vomiting, abdominal pain, and diarrhea. Management is supportive and symptomatic. Gastric lavage may be considered. Hemodialysis and peritoneal dialysis do not remove significant amounts of cefixime.
Pregnancy & Lactation
Pregnancy Category B. Use only if clearly needed. Cefixime is excreted in small amounts in breast milk; caution is advised when administered to a nursing mother.
Side Effects
Contraindications
- Hypersensitivity to cefixime or any other cephalosporin antibiotics
- History of serious hypersensitivity reactions to penicillin (due to potential cross-reactivity)
Drug Interactions
Warfarin
May enhance anticoagulant effect, increasing risk of bleeding. Monitor INR closely.
Probenecid
May increase cefixime plasma levels and prolong its duration of action.
Carbamazepine
Concomitant use may increase carbamazepine levels.
Storage
Store dry powder at controlled room temperature (20-25°C). After reconstitution, store in a refrigerator (2-8°C) and discard unused portion after 14 days (or as per label instructions).
Overdose
Symptoms may include nausea, vomiting, abdominal pain, and diarrhea. Management is supportive and symptomatic. Gastric lavage may be considered. Hemodialysis and peritoneal dialysis do not remove significant amounts of cefixime.
Pregnancy & Lactation
Pregnancy Category B. Use only if clearly needed. Cefixime is excreted in small amounts in breast milk; caution is advised when administered to a nursing mother.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months (unreconstituted powder). Once reconstituted, typically 7-14 days when refrigerated.
Availability
Pharmacies, Hospitals
Approval Status
Approved by health authorities worldwide
Patent Status
Generic available, original patent expired
WHO Essential Medicine
YesClinical Trials
Numerous clinical trials have established the efficacy and safety of cefixime in various bacterial infections, particularly in pediatric and adult populations for respiratory and urinary tract infections.
Lab Monitoring
- Renal function tests (e.g., creatinine clearance) in patients with impaired renal function
- INR/PT monitoring for patients on warfarin
- CBC in prolonged therapy
Doctor Notes
- Assess patient history for hypersensitivity to cephalosporins or penicillins.
- Adjust dose in renal impairment.
- Counsel on importance of completing the full course.
Patient Guidelines
- Complete the full course of treatment as prescribed, even if symptoms improve.
- Do not share this medicine with others.
- Shake the suspension well before each use and measure with an appropriate device.
- Report any unusual side effects or allergic reactions to your doctor.
Missed Dose Advice
Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue your regular dosing schedule. Do not double the dose.
Driving Precautions
Cefixime generally does not impair the ability to drive or operate machinery. However, if you experience dizziness or headache, avoid such activities.
Lifestyle Advice
- Maintain good hydration.
- Avoid self-medication.
- Follow a balanced diet.
Alternative Medicines in Bangladesh
Similar medicines available in the market
Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
Other Medicines in Fix-A Brand
Other medicines available under the same brand name
