Fix-A-DS
Generic Name
Cefixime
Manufacturer
Acme Laboratories Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| fix a ds 400 mg capsule | ৳ 60.00 | ৳ 420.00 |
Description
Overview of the medicine
Fix-A-DS 400 mg Capsule contains Cefixime, a third-generation cephalosporin antibiotic. It is used to treat a wide range of bacterial infections including respiratory tract infections, urinary tract infections, otitis media, pharyngitis, tonsillitis, and uncomplicated gonorrhoea.
Uses & Indications
Dosage
Adults
For most infections: 400 mg once daily or 200 mg every 12 hours for 7-14 days. For uncomplicated gonorrhoea: 400 mg as a single dose.
Elderly
No dose adjustment generally required unless severe renal impairment.
Renal_impairment
Creatinine clearance 21-60 mL/min: 300 mg daily. Creatinine clearance <20 mL/min: 200 mg daily.
How to Take
Take the capsule orally with a glass of water, with or without food. It is recommended to take it at approximately the same time each day.
Mechanism of Action
Cefixime acts by inhibiting bacterial cell wall synthesis. It binds to penicillin-binding proteins (PBPs) located inside the bacterial cell wall, which prevents the final transpeptidation step of peptidoglycan synthesis. This disruption leads to the lysis and death of susceptible bacteria.
Pharmacokinetics
Onset
1-2 hours (peak plasma concentration)
Excretion
Primarily renal (glomerular filtration and tubular secretion) and some biliary excretion.
Half life
3-4 hours
Absorption
Approximately 40-50% absorbed orally. Food may delay but not significantly reduce absorption.
Metabolism
Not extensively metabolized; primarily excreted unchanged.
Side Effects
Contraindications
- Known hypersensitivity to cefixime or any other cephalosporin antibiotics.
- History of serious hypersensitivity reactions to penicillin or other beta-lactam antibiotics.
Drug Interactions
Nifedipine
May increase cefixime peak plasma concentration and AUC.
Carbamazepine
Increased carbamazepine levels have been reported.
Warfarin and other anticoagulants
May increase prothrombin time/INR, increasing risk of bleeding. Close monitoring is advised.
Storage
Store below 30°C in a dry place, away from light. Keep out of reach of children.
Overdose
In case of overdose, gastric lavage may be indicated. Cefixime is not removed in significant quantities from the circulation by hemodialysis or peritoneal dialysis. Treatment should be symptomatic and supportive.
Pregnancy & Lactation
Pregnancy: Category B. Studies in animals have shown no evidence of harm to the fetus. Use in pregnancy only if clearly needed. Lactation: Small amounts of cefixime are excreted in human milk. Caution should be exercised when administered to a nursing mother.
Side Effects
Contraindications
- Known hypersensitivity to cefixime or any other cephalosporin antibiotics.
- History of serious hypersensitivity reactions to penicillin or other beta-lactam antibiotics.
Drug Interactions
Nifedipine
May increase cefixime peak plasma concentration and AUC.
Carbamazepine
Increased carbamazepine levels have been reported.
Warfarin and other anticoagulants
May increase prothrombin time/INR, increasing risk of bleeding. Close monitoring is advised.
Storage
Store below 30°C in a dry place, away from light. Keep out of reach of children.
Overdose
In case of overdose, gastric lavage may be indicated. Cefixime is not removed in significant quantities from the circulation by hemodialysis or peritoneal dialysis. Treatment should be symptomatic and supportive.
Pregnancy & Lactation
Pregnancy: Category B. Studies in animals have shown no evidence of harm to the fetus. Use in pregnancy only if clearly needed. Lactation: Small amounts of cefixime are excreted in human milk. Caution should be exercised when administered to a nursing mother.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months
Availability
Pharmacies nationwide
Approval Status
Approved by regulatory authorities
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials have established the efficacy and safety of cefixime in various bacterial infections.
Lab Monitoring
- Monitor renal function in patients with pre-existing renal impairment.
- Monitor prothrombin time/INR in patients concurrently taking anticoagulants.
- Periodically monitor complete blood counts with long-term therapy.
Doctor Notes
- Prescribe with caution in patients with a history of gastrointestinal disease, particularly colitis.
- Adjust dosage in patients with severe renal impairment.
- Advise patients to report any signs of hypersensitivity reactions immediately.
Patient Guidelines
- Complete the full course of antibiotics as prescribed, even if you feel better.
- Do not share this medicine with others.
- Store in a cool, dry place away from direct light and moisture.
- Inform your doctor about any unusual side effects or worsening symptoms.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.
Driving Precautions
Cefixime may cause dizziness in some patients. Patients should be cautioned about operating hazardous machinery, including automobiles, until they are reasonably certain that the drug does not adversely affect them.
Lifestyle Advice
- Maintain good hydration by drinking plenty of fluids.
- Consider taking probiotics to help prevent antibiotic-associated diarrhoea.
- Avoid alcohol during treatment as it may exacerbate side effects.
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