Fixcef
Generic Name
Cefixime
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| fixcef 250 mg tablet | ৳ 30.00 | ৳ 210.00 |
Description
Overview of the medicine
Fixcef 250 mg Tablet contains Cefixime, a third-generation cephalosporin antibiotic, used to treat a wide range of bacterial infections. It works by preventing the growth of bacteria.
Uses & Indications
Dosage
Adults
The usual adult dose is 200 mg to 400 mg daily, given as a single dose or in two divided doses. For Fixcef 250 mg, commonly 250 mg once daily or 250 mg twice daily depending on infection severity.
Elderly
No specific dose adjustment is required in elderly patients unless there is severe renal impairment.
Renal_impairment
Dosage adjustment is necessary for patients with creatinine clearance less than 60 mL/min. For CrCl 21-60 mL/min, 75% of the standard dose; for CrCl <20 mL/min, 50% of the standard dose.
How to Take
Fixcef 250 mg Tablet should be taken orally, with or without food. It is recommended to complete the full course of treatment as prescribed by the doctor, even if symptoms improve.
Mechanism of Action
Cefixime acts by inhibiting bacterial cell wall synthesis. It binds to penicillin-binding proteins (PBPs) located inside the bacterial cell wall, thereby interfering with the transpeptidation reaction which cross-links peptidoglycan strands, essential for bacterial cell wall rigidity and strength. This leads to cell lysis and bacterial death.
Pharmacokinetics
Onset
Peak plasma concentrations are achieved within 2-6 hours after administration.
Excretion
Approximately 50% of the absorbed dose is excreted unchanged in the urine over 24 hours. Some excretion also occurs via bile.
Half life
Plasma half-life averages 3-4 hours, potentially longer in elderly patients and those with renal impairment.
Absorption
Approximately 40-50% orally absorbed. Absorption is not significantly altered by food.
Metabolism
Minimal hepatic metabolism; primarily excreted as unchanged drug.
Side Effects
Contraindications
- Hypersensitivity to Cefixime or any other cephalosporin antibiotics.
- History of severe hypersensitivity (e.g., anaphylaxis) to penicillin or other beta-lactam antibiotics.
Drug Interactions
Probenecid
May increase cefixime plasma concentrations by inhibiting renal excretion.
Carbamazepine
Cefixime may increase carbamazepine levels; therapeutic drug monitoring may be necessary.
Warfarin and other anticoagulants
May increase prothrombin time/INR, leading to an increased risk of bleeding. Close monitoring is recommended.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
In case of overdose, gastric lavage may be indicated. There is no specific antidote. Cefixime is not removed in significant quantities from the circulation by hemodialysis or peritoneal dialysis. Treatment should be supportive.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have not shown harm to the fetus, but there are no adequate and well-controlled studies in pregnant women. Use during pregnancy only if clearly needed. Cefixime is excreted in small amounts in breast milk; caution should be exercised when administered to a nursing mother.
Side Effects
Contraindications
- Hypersensitivity to Cefixime or any other cephalosporin antibiotics.
- History of severe hypersensitivity (e.g., anaphylaxis) to penicillin or other beta-lactam antibiotics.
Drug Interactions
Probenecid
May increase cefixime plasma concentrations by inhibiting renal excretion.
Carbamazepine
Cefixime may increase carbamazepine levels; therapeutic drug monitoring may be necessary.
Warfarin and other anticoagulants
May increase prothrombin time/INR, leading to an increased risk of bleeding. Close monitoring is recommended.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
In case of overdose, gastric lavage may be indicated. There is no specific antidote. Cefixime is not removed in significant quantities from the circulation by hemodialysis or peritoneal dialysis. Treatment should be supportive.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have not shown harm to the fetus, but there are no adequate and well-controlled studies in pregnant women. Use during pregnancy only if clearly needed. Cefixime is excreted in small amounts in breast milk; caution should be exercised when administered to a nursing mother.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from the date of manufacture, specific details on packaging.
Availability
Available in pharmacies and hospitals
Approval Status
Approved by DGDA (Bangladesh)
Patent Status
Generic (Patent Expired)
WHO Essential Medicine
YesClinical Trials
Cefixime has undergone numerous clinical trials for efficacy and safety across various bacterial infections. For generic versions like Fixcef, bioequivalence studies are conducted to ensure comparable therapeutic effects to the reference drug.
Lab Monitoring
- Renal function tests (e.g., creatinine clearance) in patients with pre-existing renal impairment or during prolonged therapy.
- Complete blood count (CBC) during prolonged therapy.
Doctor Notes
- Consider local susceptibility patterns of bacteria when prescribing.
- Adjust dose in patients with impaired renal function.
- Counsel patients on the importance of completing the full course of therapy to prevent resistance and recurrence.
Patient Guidelines
- Always complete the full course of antibiotics as prescribed by your doctor, even if you feel better.
- Do not share this medicine with others, even if they have similar symptoms.
- Inform your doctor about any unusual or severe side effects.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to make up for a missed one.
Driving Precautions
Cefixime may cause dizziness in some individuals. Patients should be cautious when driving or operating machinery until they know how the medicine affects them.
Lifestyle Advice
- Maintain good hydration by drinking plenty of fluids during the course of treatment.
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Global Brand Names
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