Florium
Generic Name
Anxiolozam
Manufacturer
MediCorp Pharma
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| florium 5 mg tablet | ৳ 3.50 | ৳ 35.00 |
Description
Overview of the medicine
Florium 5 mg Tablet contains Anxiolozam, a benzodiazepine derivative, primarily used for the short-term treatment of anxiety disorders, insomnia, and certain seizure disorders. It acts on the central nervous system to produce a calming effect.
Uses & Indications
Dosage
Adults
For anxiety: 1-2 mg, 2-3 times daily. For insomnia: 2-4 mg at bedtime.
Elderly
Lower initial doses recommended; typically 0.5-1 mg, 1-2 times daily, adjusted as needed.
Renal_impairment
No specific dosage adjustment required, but caution is advised in severe cases.
How to Take
Take orally with or without food. Do not crush or chew the tablet; swallow whole with water.
Mechanism of Action
Anxiolozam enhances the effect of gamma-aminobutyric acid (GABA), an inhibitory neurotransmitter, by binding to specific benzodiazepine receptors on the GABAA receptor complex. This leads to increased chloride ion influx into neurons, resulting in hyperpolarization and reduced neuronal excitability.
Pharmacokinetics
Onset
Within 30-60 minutes after oral administration.
Excretion
Mainly excreted in the urine as glucuronide conjugates.
Half life
Approximately 10-20 hours.
Absorption
Rapidly and almost completely absorbed from the gastrointestinal tract.
Metabolism
Extensively metabolized in the liver, primarily via glucuronidation.
Side Effects
Contraindications
- Acute narrow-angle glaucoma
- Severe respiratory insufficiency
- Sleep apnea syndrome
- Severe hepatic impairment
- Myasthenia gravis
Drug Interactions
Opioids
Increased risk of profound sedation, respiratory depression, coma, and death.
Antacids
May delay absorption of Anxiolozam.
Antifungals (e.g., ketoconazole)
May increase Anxiolozam plasma concentrations.
Alcohol and other CNS depressants
Additive CNS depressant effects.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms include somnolence, confusion, diminished reflexes, coma. Management involves supportive care, gastric lavage if recent ingestion, and potentially flumazenil (a benzodiazepine antagonist) under strict medical supervision.
Pregnancy & Lactation
Category D in pregnancy (risk to fetus demonstrated). Use only if potential benefit justifies the potential risk to the fetus. Excreted in breast milk, so avoid during lactation or use with caution.
Side Effects
Contraindications
- Acute narrow-angle glaucoma
- Severe respiratory insufficiency
- Sleep apnea syndrome
- Severe hepatic impairment
- Myasthenia gravis
Drug Interactions
Opioids
Increased risk of profound sedation, respiratory depression, coma, and death.
Antacids
May delay absorption of Anxiolozam.
Antifungals (e.g., ketoconazole)
May increase Anxiolozam plasma concentrations.
Alcohol and other CNS depressants
Additive CNS depressant effects.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms include somnolence, confusion, diminished reflexes, coma. Management involves supportive care, gastric lavage if recent ingestion, and potentially flumazenil (a benzodiazepine antagonist) under strict medical supervision.
Pregnancy & Lactation
Category D in pregnancy (risk to fetus demonstrated). Use only if potential benefit justifies the potential risk to the fetus. Excreted in breast milk, so avoid during lactation or use with caution.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months
Availability
Pharmacies nationwide
Approval Status
Approved by DGDA
Patent Status
Patent pending
WHO Essential Medicine
YesClinical Trials
Ongoing phase III trials for long-term anxiety management; completed phase II for acute seizure control.
Lab Monitoring
- Liver function tests (periodically with prolonged use)
- Renal function tests (in patients with impairment)
Doctor Notes
- Emphasize short-term use only.
- Warn about withdrawal symptoms and dependence.
- Consider alternative non-pharmacological therapies.
Patient Guidelines
- Do not stop taking this medication abruptly due to withdrawal symptoms.
- Avoid alcohol and other CNS depressants.
- Do not drive or operate heavy machinery until you know how this medicine affects you.
- Inform your doctor about all other medications you are taking.
Missed Dose Advice
If a dose is missed, take it as soon as you remember, unless it is almost time for your next dose. Do not double the dose to catch up.
Driving Precautions
May cause drowsiness, dizziness, and impaired coordination. Avoid driving or operating machinery until you know how Florium affects you.
Lifestyle Advice
- Practice good sleep hygiene (consistent sleep schedule, comfortable environment).
- Engage in stress-reducing activities like meditation or light exercise.
- Avoid caffeine and heavy meals before bedtime.
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