Flu-K
Generic Name
Flucloxacillin 500 mg capsule
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| flu k 500 mg capsule | ৳ 10.53 | N/A |
Description
Overview of the medicine
Flucloxacillin is a penicillin antibiotic used to treat a wide range of bacterial infections, especially those caused by penicillinase-producing staphylococci.
Uses & Indications
Dosage
Adults
250-500 mg every 6 hours, taken on an empty stomach. Severe infections may require higher doses.
Elderly
Similar to adults, but renal function should be assessed, and dose adjustment may be necessary in severe renal impairment.
Renal_impairment
Dose adjustment required based on creatinine clearance. For CrCl < 10 mL/min, maximum 1g in 24 hours.
How to Take
Take orally, preferably on an empty stomach (at least 30-60 minutes before meals or 2 hours after meals) to ensure maximum absorption.
Mechanism of Action
Flucloxacillin works by interfering with the synthesis of the bacterial cell wall, leading to cell lysis and death. It is resistant to degradation by penicillinase.
Pharmacokinetics
Onset
Rapid, with bactericidal effects starting soon after administration.
Excretion
Primarily excreted unchanged in the urine, with a small amount excreted in bile.
Half life
Approximately 0.5 to 1.5 hours in individuals with normal renal function.
Absorption
Well absorbed orally, though absorption is reduced by food. Peak plasma concentrations are achieved within 1-2 hours.
Metabolism
Partially metabolized in the liver to inactive metabolites.
Side Effects
Contraindications
- Hypersensitivity to flucloxacillin, other penicillins, or any component of the formulation.
- History of flucloxacillin-associated jaundice/hepatic dysfunction.
Drug Interactions
Warfarin
May increase the anticoagulant effect of warfarin, requiring close monitoring of INR.
Probenecid
Delays the renal excretion of flucloxacillin, leading to increased and prolonged plasma concentrations.
Methotrexate
May reduce the renal clearance of methotrexate, potentially increasing its toxicity.
Oral Contraceptives
Rarely, antibiotics can reduce the efficacy of oral contraceptives; consider additional barrier contraception.
Storage
Store below 30°C in a dry place, away from direct sunlight and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose are generally an exaggeration of adverse effects. Management is largely symptomatic and supportive, including gastric lavage or activated charcoal if appropriate, and monitoring of vital signs and renal function.
Pregnancy & Lactation
Pregnancy Category B. Flucloxacillin is generally considered safe during pregnancy. Small amounts are excreted in breast milk; generally considered compatible with breastfeeding, but monitor the infant for gastrointestinal disturbances or candidiasis.
Side Effects
Contraindications
- Hypersensitivity to flucloxacillin, other penicillins, or any component of the formulation.
- History of flucloxacillin-associated jaundice/hepatic dysfunction.
Drug Interactions
Warfarin
May increase the anticoagulant effect of warfarin, requiring close monitoring of INR.
Probenecid
Delays the renal excretion of flucloxacillin, leading to increased and prolonged plasma concentrations.
Methotrexate
May reduce the renal clearance of methotrexate, potentially increasing its toxicity.
Oral Contraceptives
Rarely, antibiotics can reduce the efficacy of oral contraceptives; consider additional barrier contraception.
Storage
Store below 30°C in a dry place, away from direct sunlight and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose are generally an exaggeration of adverse effects. Management is largely symptomatic and supportive, including gastric lavage or activated charcoal if appropriate, and monitoring of vital signs and renal function.
Pregnancy & Lactation
Pregnancy Category B. Flucloxacillin is generally considered safe during pregnancy. Small amounts are excreted in breast milk; generally considered compatible with breastfeeding, but monitor the infant for gastrointestinal disturbances or candidiasis.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24-36 months from manufacturing date, check specific packaging for exact expiry.
Availability
Pharmacies, Hospitals
Approval Status
Approved
Patent Status
Generic available
WHO Essential Medicine
YesClinical Trials
Flucloxacillin has undergone extensive clinical trials to establish its efficacy and safety in various bacterial infections. Ongoing post-marketing surveillance continues to monitor its long-term effects.
Lab Monitoring
- Liver function tests (especially with prolonged use or in patients with pre-existing hepatic impairment)
- Renal function tests (in patients with renal impairment)
- Full blood count (for prolonged therapy)
Doctor Notes
- Emphasize the importance of completing the full course of therapy to prevent resistance.
- Advise patients to take flucloxacillin on an empty stomach for optimal absorption.
- Be vigilant for signs of hepatic dysfunction, particularly delayed onset cholestatic jaundice, even after discontinuing the drug.
Patient Guidelines
- Complete the full prescribed course of antibiotics, even if symptoms improve, to prevent the development of antibiotic resistance.
- Take the medicine on an empty stomach for better absorption.
- Report any persistent or severe side effects to your doctor immediately.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Flucloxacillin is not known to affect the ability to drive or operate machinery. However, if you experience dizziness or other side effects that could impair concentration, avoid these activities.
Lifestyle Advice
- Maintain good hydration by drinking plenty of fluids.
- Practice good hygiene to prevent the spread of infections.
Alternative Medicines in Bangladesh
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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