Flubiotic
Generic Name
Flumoxacin
Manufacturer
MediTech Pharmaceuticals
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| flubiotic 250 mg capsule | ৳ 5.55 | ৳ 22.20 |
Description
Overview of the medicine
Flubiotic 250 mg Capsule is a broad-spectrum antibiotic used to treat a variety of bacterial infections, including respiratory, urinary, and skin infections.
Uses & Indications
Dosage
Adults
For most infections, 250 mg once daily or 125 mg twice daily. Severe infections may require 500 mg once daily.
Elderly
No specific dose adjustment needed unless severe renal impairment is present. Monitor renal function.
Renal_impairment
Dose reduction is required for creatinine clearance (CrCl) < 30 mL/min. Consult prescribing information for specific guidelines.
How to Take
Take Flubiotic 250 mg Capsule orally with a glass of water, with or without food. Do not chew, crush, or break the capsule. Swallow it whole.
Mechanism of Action
Flumoxacin inhibits bacterial DNA gyrase and topoisomerase IV, enzymes essential for bacterial DNA replication, transcription, repair, and recombination. This leads to bacterial cell death.
Pharmacokinetics
Onset
Antibacterial effects typically begin within 1-2 hours of administration.
Excretion
Mainly excreted through renal excretion (urine), with a smaller portion eliminated via biliary/fecal routes.
Half life
The elimination half-life is approximately 8-10 hours, allowing for once or twice daily dosing.
Absorption
Rapidly absorbed from the gastrointestinal tract following oral administration, with peak plasma concentrations achieved within 1-2 hours.
Metabolism
Primarily metabolized in the liver via CYP450 enzymes, with several active and inactive metabolites formed.
Side Effects
Contraindications
- •Hypersensitivity to flumoxacin, other quinolones, or any component of the formulation
- •History of tendinitis or tendon rupture associated with quinolone use
- •Children and adolescents below 18 years of age due to potential musculoskeletal adverse effects
- •Patients with myasthenia gravis
Drug Interactions
NSAIDs
May increase the risk of CNS stimulation and convulsions.
Warfarin
May enhance the anticoagulant effect of warfarin, increasing the risk of bleeding. Close monitoring of INR is recommended.
Corticosteroids
Concomitant use increases the risk of tendon rupture.
Antacids, iron supplements, multivitamins containing zinc
May significantly reduce the absorption of flumoxacin. Administer Flubiotic at least 2 hours before or 6 hours after these products.
Storage
Store below 30°C in a dry place, protected from light and moisture. Keep out of reach and sight of children.
Overdose
Symptoms of Flubiotic overdose may include nausea, vomiting, diarrhea, abdominal pain, dizziness, confusion, seizures, and prolonged QT interval. In case of overdose, seek immediate medical attention. Treatment is symptomatic and supportive, including gastric lavage and adequate hydration.
Pregnancy & Lactation
Flubiotic is generally not recommended during pregnancy or lactation due to potential risks to the fetus and infant, including adverse effects on cartilage development. Use only if the potential benefit outweighs the potential risk, and under strict medical supervision.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months from the date of manufacture.
Availability
Pharmacies nationwide
Approval Status
Approved by DGDA
Patent Status
Patent pending
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Global Brand Names
International brand names for this medicine
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