Adults

For systemic candidiasis: 400 mg on day 1, then 200-400 mg once daily. For cryptococcal meningitis: 400 mg on day 1, then 200-400 mg once daily for 6-8 weeks. For oropharyngeal candidiasis: 50-100 mg once daily for 7-14 days. For vaginal candidiasis, a single 150 mg dose is typical; 200 mg may be used for other specific fungal infections as per doctor's advice.

Elderly

Dosage adjustments usually not necessary unless renal function is impaired. If renal impairment is present, refer to renal impairment dosage.

Renal_impairment

Dosage adjustment required based on creatinine clearance (CrCl). If CrCl > 50 mL/min, use usual dose. If CrCl ≤ 50 mL/min, administer 50% of the recommended daily dose after the initial loading dose (if applicable).

Onset

Varies by infection type, generally symptomatic improvement within days for superficial infections.

Excretion

Primarily renal, approximately 80% of the dose excreted unchanged in urine.

Half life

Approximately 30 hours, allowing for once-daily dosing.

Absorption

Well absorbed orally (>90% bioavailability), peak plasma concentrations reached within 0.5-1.5 hours.

Metabolism

Minimal hepatic metabolism, primarily excreted as unchanged drug.

Warfarin

Increased prothrombin time (PT/INR), monitor for bleeding.

Phenytoin

Increased phenytoin levels, monitor for toxicity.

Rifampicin

Decreased Fluconazole plasma levels, consider increasing Fluconazole dose.

Hydrochlorothiazide

Increased Fluconazole plasma levels.

Oral contraceptives

May increase or decrease levels of some components of oral contraceptives, though generally not clinically significant.

Cyclosporine/Tacrolimus

Increased levels of these immunosuppressants, monitor renal function and drug levels.

Oral Hypoglycemics (e.g., sulfonylureas)

Increased plasma concentration of sulfonylureas, leading to a risk of hypoglycemia.