Fluderm
Generic Name
Fluconazole
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| fluderm 50 mg tablet | ৳ 9.00 | ৳ 90.00 |
Description
Overview of the medicine
Fluderm 50 mg Tablet contains Fluconazole, an antifungal medication used to treat a variety of fungal infections, including vaginal yeast infections, oral thrush, and fungal infections of the esophagus, abdomen, lungs, and blood.
Uses & Indications
Dosage
Adults
For vaginal candidiasis: 150 mg single oral dose. For oropharyngeal candidiasis: 50-100 mg once daily for 7-14 days. For systemic candidiasis: 400 mg on day 1, then 200-400 mg once daily.
Elderly
No dosage adjustment needed unless renal impairment is present. Adjust dose based on creatinine clearance.
Renal_impairment
Reduce dose by 50% if creatinine clearance is <50 mL/min. For patients on hemodialysis, give a full dose after each dialysis session.
How to Take
Swallow the tablet whole with a glass of water, with or without food. Take at approximately the same time each day.
Mechanism of Action
Fluconazole inhibits fungal cytochrome P450-dependent 14-alpha-demethylation of lanosterol, which is an essential step in fungal ergosterol biosynthesis. This inhibition leads to a depletion of ergosterol in the fungal cell membrane and a buildup of methylated sterol precursors, resulting in increased cell membrane permeability and cell death.
Pharmacokinetics
Onset
Clinical effects typically observed within a few days for most indications, though plasma levels peak within 1-2 hours.
Excretion
Primarily excreted unchanged in the urine; about 80% of the dose is excreted unchanged by the kidneys.
Half life
Approximately 30 hours (range 20-50 hours).
Absorption
Well absorbed from the gastrointestinal tract. Oral bioavailability is over 90%.
Metabolism
Minimally metabolized; approximately 11% of the dose is metabolized.
Side Effects
Contraindications
- •Hypersensitivity to fluconazole or other azole antifungals
- •Co-administration with terfenadine, astemizole, cisapride, pimozide, quinidine, or erythromycin
Drug Interactions
Warfarin
Increased prothrombin time, monitor INR.
Phenytoin
Increased phenytoin levels, monitor.
Rifampicin
Decreased fluconazole levels, consider dose increase.
Oral Sulfonylureas
Increased serum concentration, risk of hypoglycemia.
Hydrochlorothiazide
Increased fluconazole levels.
Statins (e.g., Atorvastatin)
Increased statin levels, risk of myopathy.
Benzodiazepines (e.g., Midazolam)
Increased benzodiazepine levels, prolonged sedation.
Cyclosporine, Tacrolimus, Sirolimus
Increased immunosuppressant levels, monitor renal function.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms may include hallucinations and paranoid behavior. Treatment involves symptomatic and supportive care; hemodialysis can accelerate fluconazole elimination.
Pregnancy & Lactation
Pregnancy Category D (single dose for vaginal candidiasis may be category C). Use in pregnancy only if potential benefit justifies potential risk. Fluconazole is excreted in breast milk; caution advised during lactation.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24-36 months from manufacturing date
Availability
Pharmacies nationwide
Approval Status
Approved by regulatory authorities
Patent Status
Off-patent
WHO Essential Medicine
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Global Brand Names
International brand names for this medicine
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