Fluzole
Generic Name
Fluconazole 150 mg tablet
Manufacturer
XYZ Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| fluzole 150 mg tablet | ৳ 22.00 | ৳ 220.00 |
Description
Overview of the medicine
Fluzole 150 mg tablet contains fluconazole, an antifungal medication used to treat various fungal infections.
Uses & Indications
Dosage
Adults
For vaginal candidiasis: 150 mg as a single oral dose. For other indications, dosage varies; consult physician.
Elderly
No dosage adjustment usually required unless renal impairment is present.
Renal_impairment
Dosage adjustment required based on creatinine clearance.
How to Take
Oral. Can be taken with or without food.
Mechanism of Action
Inhibits fungal cytochrome P450-dependent 14α-lanosterol demethylation, essential for ergosterol synthesis.
Pharmacokinetics
Onset
Typically within 1-2 hours for peak plasma concentrations.
Excretion
Mainly renal (80% unchanged drug).
Half life
Approximately 30 hours.
Absorption
Well absorbed orally, bioavailability >90%.
Metabolism
Minimally metabolized; primarily excreted unchanged.
Side Effects
Contraindications
- Hypersensitivity to fluconazole or other azole antifungals
- Concomitant use with terfenadine, astemizole, cisapride, pimozide, quinidine, or erythromycin (due to QTc prolongation risk)
Drug Interactions
Warfarin
Increased prothrombin time/INR.
Phenytoin
Increased phenytoin levels.
Rifampicin
Decreased fluconazole levels.
Sulfonylureas
Increased blood glucose lowering effect.
Tacrolimus/Ciclosporin
Increased levels of immunosuppressants.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms may include hallucinations and paranoid behavior. Gastric lavage and supportive measures, possibly hemodialysis, may be necessary.
Pregnancy & Lactation
Use in pregnancy only if potential benefit justifies the potential risk to the fetus. Not recommended during breastfeeding as it is excreted in breast milk.
Side Effects
Contraindications
- Hypersensitivity to fluconazole or other azole antifungals
- Concomitant use with terfenadine, astemizole, cisapride, pimozide, quinidine, or erythromycin (due to QTc prolongation risk)
Drug Interactions
Warfarin
Increased prothrombin time/INR.
Phenytoin
Increased phenytoin levels.
Rifampicin
Decreased fluconazole levels.
Sulfonylureas
Increased blood glucose lowering effect.
Tacrolimus/Ciclosporin
Increased levels of immunosuppressants.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms may include hallucinations and paranoid behavior. Gastric lavage and supportive measures, possibly hemodialysis, may be necessary.
Pregnancy & Lactation
Use in pregnancy only if potential benefit justifies the potential risk to the fetus. Not recommended during breastfeeding as it is excreted in breast milk.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24 to 36 months from manufacturing date.
Availability
Pharmacies, Hospitals
Approval Status
Approved by regulatory bodies (e.g., FDA, DGDA)
Patent Status
Generic available
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials have established the efficacy and safety of fluconazole for various fungal infections.
Lab Monitoring
- Liver function tests (LFTs) for long-term use or in patients with liver impairment.
- Renal function for patients with kidney issues.
- Electrolytes (e.g., potassium, magnesium) if QTc prolongation risk factors are present.
Doctor Notes
- Monitor LFTs if prescribing for prolonged periods or in patients with pre-existing hepatic disease.
- Counsel patients on potential drug interactions, especially with warfarin and sulfonylureas.
Patient Guidelines
- Complete the full course of treatment as prescribed, even if symptoms improve.
- Inform your doctor about all other medications you are taking.
- Seek medical attention if you experience severe side effects or allergic reactions.
Missed Dose Advice
Take the missed dose as soon as you remember. If it's almost time for the next dose, skip the missed dose and continue your regular schedule. Do not double the dose.
Driving Precautions
May cause dizziness in some individuals. Avoid driving or operating machinery until you know how this medicine affects you.
Lifestyle Advice
- Maintain good personal hygiene to prevent recurrence of fungal infections.
- Wear breathable clothing, especially for skin and vaginal candidiasis.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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