Fluzole
Generic Name
Fluconazole
Manufacturer
Hypothetical Pharma Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| fluzole 50 mg tablet | ৳ 8.00 | ৳ 80.00 |
Description
Overview of the medicine
Fluzole 50 mg Tablet contains Fluconazole, an antifungal medication used to treat a variety of fungal and yeast infections. It belongs to the azole class of antifungals and works by inhibiting the growth of fungi. It is effective against candidiasis, cryptococcosis, and other susceptible fungal infections.
Uses & Indications
Dosage
Adults
Vaginal candidiasis: 150 mg single oral dose. Oropharyngeal candidiasis: 50-100 mg once daily for 7-14 days. Esophageal candidiasis: 100-200 mg once daily for 14-30 days. For other systemic infections, dosage may vary, usually 100-400 mg daily.
Elderly
No dosage adjustment is typically required unless there is renal impairment. Dose should be adjusted based on creatinine clearance.
Renal_impairment
For patients with creatinine clearance < 50 mL/min, the dose should be reduced by 50% after an initial loading dose.
How to Take
Fluzole tablets should be swallowed whole with water, with or without food. For oral candidiasis, swishing and swallowing the liquid suspension may be preferred for better local action, but tablets are generally swallowed. Complete the full course of treatment as prescribed.
Mechanism of Action
Fluconazole inhibits the fungal cytochrome P450 enzyme 14α-demethylase, which is responsible for converting lanosterol to ergosterol. Ergosterol is an essential component of the fungal cell membrane; its inhibition leads to increased cellular permeability and leakage of cellular contents, ultimately causing fungal cell death.
Pharmacokinetics
Onset
Within 1-2 days for most infections, a single dose for vaginal candidiasis can show improvement within 24 hours.
Excretion
Primarily excreted unchanged by the kidneys (approx. 80% of the dose).
Half life
Approximately 30 hours, allowing for once-daily dosing in many indications.
Absorption
Well absorbed orally (over 90% bioavailability); food does not significantly affect absorption.
Metabolism
Minimally metabolized; about 11% of the dose is metabolized to less active metabolites.
Side Effects
Contraindications
- Hypersensitivity to Fluconazole or other azole antifungals.
- Co-administration with terfenadine, astemizole, cisapride, pimozide, quinidine, or erythromycin in patients receiving multiple doses of fluconazole.
Drug Interactions
Warfarin
Increased prothrombin time, monitor INR.
Phenytoin
Increased phenytoin levels, monitor for toxicity.
Rifampicin
Decreased fluconazole levels, consider increasing fluconazole dose.
Cyclosporine, Tacrolimus
Increased levels of immunosuppressants, monitor levels.
Oral Hypoglycemics (e.g., sulfonylureas)
Increased blood glucose lowering effect, monitor blood sugar.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
In case of overdose, symptoms may include hallucinations and paranoid behavior. Management should be symptomatic and supportive, including gastric lavage if appropriate and hemodialysis, which significantly decreases plasma levels.
Pregnancy & Lactation
Pregnancy Category D for chronic use or high doses; Category C for single-dose vaginal candidiasis. Avoid during pregnancy unless the benefits outweigh the risks. Excreted into breast milk; caution is advised during breastfeeding.
Side Effects
Contraindications
- Hypersensitivity to Fluconazole or other azole antifungals.
- Co-administration with terfenadine, astemizole, cisapride, pimozide, quinidine, or erythromycin in patients receiving multiple doses of fluconazole.
Drug Interactions
Warfarin
Increased prothrombin time, monitor INR.
Phenytoin
Increased phenytoin levels, monitor for toxicity.
Rifampicin
Decreased fluconazole levels, consider increasing fluconazole dose.
Cyclosporine, Tacrolimus
Increased levels of immunosuppressants, monitor levels.
Oral Hypoglycemics (e.g., sulfonylureas)
Increased blood glucose lowering effect, monitor blood sugar.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
In case of overdose, symptoms may include hallucinations and paranoid behavior. Management should be symptomatic and supportive, including gastric lavage if appropriate and hemodialysis, which significantly decreases plasma levels.
Pregnancy & Lactation
Pregnancy Category D for chronic use or high doses; Category C for single-dose vaginal candidiasis. Avoid during pregnancy unless the benefits outweigh the risks. Excreted into breast milk; caution is advised during breastfeeding.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months from the date of manufacture.
Availability
Pharmacies nationwide
Approval Status
Approved by regulatory authorities
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Fluconazole has undergone extensive clinical trials demonstrating its efficacy and safety in various fungal infections. Studies have shown high cure rates for candidiasis and cryptococcosis.
Lab Monitoring
- Liver function tests (LFTs) should be monitored, especially in patients with pre-existing hepatic impairment or those on prolonged therapy.
- Renal function tests (RFTs) for dose adjustment in patients with renal impairment.
Doctor Notes
- Caution should be exercised when prescribing Fluconazole to patients with pre-existing liver disease or those receiving other hepatotoxic agents.
- Monitor for signs of QT prolongation in patients with cardiac risk factors, and consider drug interactions carefully.
- Ensure patients complete the full course of therapy to prevent resistance and recurrence.
Patient Guidelines
- Take the medicine exactly as prescribed by your doctor and complete the full course of treatment, even if symptoms improve.
- Do not share this medicine with others, even if they have similar symptoms.
- Inform your doctor about all other medications, supplements, and herbal products you are taking.
- Report any unusual side effects, especially severe rash, jaundice, or changes in urine color, to your doctor immediately.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.
Driving Precautions
Fluconazole may cause dizziness or seizures in some individuals. Patients should be advised to exercise caution when driving or operating machinery until they know how the medication affects them.
Lifestyle Advice
- Maintain good hygiene to prevent reinfection, especially for vaginal yeast infections.
- Avoid excessive alcohol consumption while on Fluconazole, as both can affect liver function.
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