Medicine Information

Furotil

Name: Furotil
Brand: Furotil
Rating: 4.5 (117 reviews)

Tablet125 mgAntibiotics (2nd Generation Cephalosporins)ATC: J01DC02

Generic Name

Cefuroxime Axetil

Manufacturer

Square Pharmaceuticals Ltd.

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
furotil 125 mg tablet	৳ 15.00 ((2 x 6: ৳ 180.00))	৳ 90.00

Description

Overview of the medicine

Furotil 125 mg Tablet contains Cefuroxime Axetil, a second-generation cephalosporin antibiotic. It is used to treat a wide range of bacterial infections.

Uses & Indications

Upper and lower respiratory tract infections (e.g., bronchitis, pneumonia)

Urinary tract infections (e.g., pyelonephritis, cystitis)

Skin and soft tissue infections (e.g., furunculosis, impetigo)

Gonorrhea (uncomplicated acute urethritis and cervicitis)

Early Lyme disease

Dosage

Adults

250 mg to 500 mg twice daily depending on the infection severity and type. For Furotil 125 mg, this typically means two tablets twice daily for certain infections or as directed by physician.

Elderly

No specific dose reduction required unless renal function is significantly impaired. Monitor renal function.

Renal_impairment

Dosage adjustment is necessary in patients with severe renal impairment (creatinine clearance < 30 mL/min). A reduced frequency or dose may be advised.

How to Take

Take orally, preferably with food, to enhance absorption. Do not crush or chew the tablet; swallow whole.

Mechanism of Action

Cefuroxime Axetil exerts its bactericidal effect by inhibiting bacterial cell wall synthesis. It binds to penicillin-binding proteins (PBPs) in the bacterial cell wall, which prevents the formation of cross-links between peptidoglycan chains, leading to cell lysis and bacterial death.

Pharmacokinetics

Onset

Peak plasma concentrations reached approximately 2-3 hours after oral administration.

Excretion

Excreted unchanged in the urine, primarily via glomerular filtration and tubular secretion.

Half life

Approximately 1.2 to 1.5 hours.

Absorption

Rapidly absorbed from the gastrointestinal tract and hydrolyzed to cefuroxime. Absorption is enhanced with food.

Metabolism

Not extensively metabolized in the body.

Side Effects

Contraindications

Hypersensitivity to cefuroxime, other cephalosporins, or any component of the formulation.
History of severe hypersensitivity reaction to any other type of beta-lactam antibacterial agent (e.g., penicillins, monobactams, carbapenems).

Drug Interactions

Probenecid

Concomitant administration with probenecid increases the area under the serum concentration versus time curve by 50%.

Oral anticoagulants

May potentiate the anticoagulant effect. Monitor INR/PT.

Oral contraceptives

May reduce the efficacy of oral contraceptives; advise additional barrier method.

Antacids/H2 blockers/PPIs

May reduce the bioavailability of cefuroxime. Administer at least 1-2 hours apart if possible.

Storage

Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.

Overdose

Overdose symptoms include cerebral irritation leading to convulsions. Treatment is symptomatic and supportive. Hemodialysis and peritoneal dialysis can effectively remove cefuroxime from the body.

Pregnancy & Lactation

Pregnancy Category B. Cefuroxime has been studied in pregnant women and has not shown an increased risk of fetal abnormalities. It is excreted in human milk in small concentrations; caution should be exercised when administered to a nursing mother.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

10 tablets (1x10 strip)20 tablets (2x10 strips)

Shelf Life

Typically 2-3 years from the date of manufacture, consult the packaging for exact date.

Availability

Available in pharmacies worldwide

Approval Status

Approved by regulatory authorities worldwide

Patent Status

Off-patent (generic versions available)

WHO Essential Medicine

Yes

Clinical Trials

Cefuroxime Axetil has undergone extensive clinical trials demonstrating its efficacy and safety across a wide range of bacterial infections. Post-marketing surveillance continues to monitor its use.

Lab Monitoring

Renal function tests (e.g., creatinine, BUN) in patients with pre-existing renal impairment or during prolonged therapy.
Complete blood count (CBC) for prolonged courses to monitor for blood dyscrasias.
Liver function tests (LFTs) if clinically indicated.

Doctor Notes

Emphasize patient compliance to complete the full course to prevent resistance.
Caution in patients with known penicillin allergy history; monitor for cross-reactivity.
Consider renal function adjustment in elderly or renally impaired patients.

Patient Guidelines

Complete the entire course of medication, even if symptoms improve.
Take with food to improve absorption and reduce stomach upset.
Do not share this medication with others.
Report any unusual or severe side effects to your doctor.

Missed Dose Advice

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.