Adults

250 mg to 500 mg twice daily depending on the infection severity and type. For Furotil 125 mg, this typically means two tablets twice daily for certain infections or as directed by physician.

Elderly

No specific dose reduction required unless renal function is significantly impaired. Monitor renal function.

Renal_impairment

Dosage adjustment is necessary in patients with severe renal impairment (creatinine clearance < 30 mL/min). A reduced frequency or dose may be advised.

Onset

Peak plasma concentrations reached approximately 2-3 hours after oral administration.

Excretion

Excreted unchanged in the urine, primarily via glomerular filtration and tubular secretion.

Half life

Approximately 1.2 to 1.5 hours.

Absorption

Rapidly absorbed from the gastrointestinal tract and hydrolyzed to cefuroxime. Absorption is enhanced with food.

Metabolism

Not extensively metabolized in the body.

Probenecid

Concomitant administration with probenecid increases the area under the serum concentration versus time curve by 50%.

Oral anticoagulants

May potentiate the anticoagulant effect. Monitor INR/PT.

Oral contraceptives

May reduce the efficacy of oral contraceptives; advise additional barrier method.

Antacids/H2 blockers/PPIs

May reduce the bioavailability of cefuroxime. Administer at least 1-2 hours apart if possible.